I don’t know exactly how it helps but I’m talking based on my experience more so than actual scientific/medical literature. I also read some reviews on reddit, and many were saying same thing. As to where to buy it I actually sourced it from India about one year or so ago, and don’t remember exactly from who but it must have been through usual ones r.e. Maulik or Jagdish
I was hesitant to take it but took the plunge about week ago and it absolutely amazing what it has done for calmness and the way it improved my sleep (nothing else has helped me at all with my sleep issue which i started having about 3 years ago). My layman’s explanation for helping with sleep is because the positive effects it has in preserving dopamine in the brain and I am by nature a bit impulsive and perhaps the impulsiveness might have been wreaking havoc on my brain dopamine levels, as such my sleeping issues. Since Seleginline protects dopamine from breaking down, it also seems to help with oxidative stress such process (dopamine breakdown) produces. so all in all for time being, I’m on cloud nine, I hope it will last (its positive impact on sleep) going forward because I’ve been a tortured soul for last three years or so (living on 5-6 hours of sleep) and nothing has helped not even remotely (from up to 100mg of melatonin, to 10’s of supposed helpful supplements, to many other things such as no screen time after 8pm etc., all in total 100% vain, except 1.25mg of Selegiline).
Difficult to classify this but I capture this “thought” as GPT was scrolling rapidly across the screen was analyzing a problem on well evidenced geroprotectives. I found the notion worth sharing:
“A preliminary pattern is already clear. The strongest human-outcome case is not with classic “longevity supplements,” but with a handful of cardiometabolic drug classes that repeatedly lower mortality and major age-related events; the supplement side is thinner and more heterogeneous.”
By the way, SGLT2-i’s came out on the top of this particular screen.
Yes. And, sans several pages of analysis, here is this screen’s bottom line:
My integrated ranking
If I combine the two axes you specified (strength of evidence supporting human impact and magnitude of impact distinguished from strength) and ask, “Which agents are currently most defensible as human geroprotective candidates?” my ordered list would be:
SGLT2 inhibitors — strongest broad hard-outcome late-life signal
GLP-1 receptor agonists — strong hard outcomes, phenotype-dependent
Metformin — enduring but now clearly mixed
ARBs — increasingly persuasive, especially for cognitive/vascular aging; telmisartan particularly interesting
Rapalogs/TORC1 inhibitors — biologically elite, clinically not mature; could move up but more likely static or down the list
Statins — powerful but narrower, mostly vascular geroprotection
@kelman tnx for all that. Memory is returning re seleginline. Please google for yourself. I believe it wears off if taken daily continuously. I vaguely remember the Florida long time ago anti aging Dr (??) one trick pony re seleginline, suggested to pulse 1-5mg every few days. Thats all I recall. If you fine tune or find zero desensitizing please post back. I’ll add this to my search for drug list when I ask the suppliers next time.
I will update in few days’ time, but I do expect to get some desensitizing as it has actually happened (in varying degrees) with everything new I have ever tried. My hope is It will still help me with my sleep issue (staying asleep) as that has been my Achillies heel (for my health and longevity journey) in last 2-3 years (survived, barely lol on only 5-6 hours of sleep) and thankfully I’m back at getting 8 hours of good sleep every night ever since I started selegiline. Nothing else under the sun did anything even remotely to help. There were couple times I was able to get 1 or 2 nights of good sleep (when I might have tried something new) but then I’d go back to my usual of waking up at 3AM and not being able to get back to sleep. So while 4 nights is not long enough to proclaim my problem is solved, it’s at least the longest I’ve experienced. Keeping my fingers crossed it will continue.
The price I got when I bought was 15 cents per pill. I bought 100 pills of 5mg for a quoted price of $15 + shipping but I had other meds with this shipment so the shipping cost would have to be prorated to come up with the correct price per pill. Btw mine is selgin.
I just played with the SuppCo app and was impressed by how fast and easy it is to use.
There are a couple of things that make me wonder if it’s suggestions are biased… I don’t know that they are, but I’m asking.
For one, I see Mark Hyman is involved and I frankly don’t trust anything that comes out of his mouth… it doesn’t mean it’s not trustworthy, but it’s my red flag to wonder if their most trusted brand recommendations are those that he/they are getting money from??? (If you followed his recommended stack in the app, you’d be taking resveratrol
It showed that my NOW supplements have trusted scores in the 7’s out of 10. This might be true, but I was turned onto using NOW from all of you who think highly of them. Thoughts?
And my second biggest red flag, after Hyman, is I know @CronosTempi is incredibly meticulous about sourcing everything, and he told me AOR is one of his favorite brands. I’m taking their magnesium malate. The app showed me the AOR malate has a trust score of 5.85 and is brining the quality of my entire stack down. Hmmm??
I really like how you can search for alternatives with the highest trust scores, but I’m sincerely wondering if I can trust them?? The brands they are recommending to me seem to largely be ‘professional’ brands… the ones often sold by practitioners. They might truly be the highest quality brands, but I have not heard this is true?
It is really neat how they calculate and share how much of x supplement you are taking (mine are in a spreadsheet so I already knew this, but this app takes away the need to figure anything out on your own). If you want to adjust your dosing (for example, you onky take something once per week) you would have to pay them.
The thing I hate is it showed me what I am spending and I just might throw up. I might rethink a few things!
I don’t rely on SuppCo for recommendations. I usually check with consumerlab.com for their supplement recommendations.
I also am put off by Dr. Hyman. I think he’s a bit of a snake oil salesman. However, I find the app useful and doubt he had much to do with its design or programming.
You’ve got to try one more and guaranteed you’d put it on top of that list, 1.25mg (or 1/4th) of Selegiline. Try it and you’ll see. I had same reaction as you when I tried LDN but Selegiline is exactly like LDN but multiplied by a factor of 10 LOL. I still take LDN and still like it, but Selegiline is by far my favorite now.
I know there’s some chatter about it being a MAO-b inhibitor and how you should be careful not to eat certain foods, but from all the research I’ve done in small doses that I’m taking it (1.25mg) one needs NOT to worry about those things.
“Low-dose Selegiline, also known as Deprenyl, has been shown to prolong lifespan in animal studies. Dr. Joseph Knoll’s pioneering research demonstrated that Deprenyl treatment increased the average lifespan by 34% in rats.”
Selegiline, a selective MAO-B inhibitor, has a unique neurological focus that sets it apart from other life-extension drugs like rapamycin, metformin, and NAD+ boosters. While these compounds target various aspects of aging, Selegiline specifically promotes neuronal health and resilience, making it an attractive option for those looking to support brain health.
Selegiline’s anti-aging effects may be enhanced when combined with metabolic or antioxidant compounds. Its MAO-B inhibition promotes neuronal protection and plasticity, offering potential synergies with compounds like metformin, rapamycin, or NAD+ boosters. This makes Selegiline a promising option for reversing age-related cognitive decline and promoting healthy brain aging.
I hope not. It seems that LDN is favored by many, but it had no effect on my sleep at any dose that I have tried. What it did do for me was ruin the taste of many things.
"The difference in how people respond to Low-Dose Naltrexone (LDN) is often due to its highly individualized nature, where “one size does not fit all”.
“While some find it transformative for sleep, others see no change because of biological variations and dosing complexities.”
LDN affecting the taste of things is unusual, but it is known to affect appetite. That is something I don’t need. I am surprised more people aren’t trying it for weight loss.
In any case, I will order and give 5 mg selegiline a try for: “This makes selegiline a promising option for reversing age-related cognitive decline and promoting healthy brain aging benefits.” Still another drug to try in my ever-increasing longevity stack.
In the case of selegine, I will base its benefits on a purely subjective measure. If I don’t feel any cognitive effects or it has any unwanted side effects, I will quit taking it.
LDN had zero effect on my sleep also. I was referring to an overall calming effect that one gets from LDN and Selegiline does same but wayyyyy better. I don’t know if you’ve tried Selegiline yet, or if you even have a sleeping issue but for me it seems to be the one and only one to fix my sleeping problems, which is to say to help me stay asleep for a good eight hours. I still woke up in the middle of night (last couple nights), but had no problem getting back to sleep., I know it is the Selegiline making the difference because everything else is the same and the only new thing I added was Selegiline.
The way I feel on Selegiline it is kind of hard to describe but it is something like the calmness before a storm, but the storm never comes LOL. I know I’ll have a great night of sleep again tonight because I feel exactly (good) as I was felling yesterday this time of day and last night had an amazing night of sleep. I would have literally paid $50K (even more but I’m not rich lol) to find a cure for my sleeping issue and it seems I found it via a 15-cent pill LOL. I still want to give it about 10 days before I celebrate, and I put this matter to rest for good.
BTW, I must thank you because it was about a year or so ago that you’d suggested it to me (thus the reason I had bought it) and I don’t even know if you’d tried it yet but remember you suggesting it as a good candidate to try (among few other things) and even though I bought it then I never tried it. I’m always reluctant to try drugs that have neurological effects until I find nothing else that helps.
[The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015) -
Have you noticed any significant cognitive effects other than its calming benefits?
You seem to have an atypical reaction to selegaline. Because it is more often reported to produce insomnia than improve sleep.
Two comparison tables from AIs, Gemini and Claude?
Claude:
Very good point and to be honest I took it to fight the midafternoon sluggishness I was having (mostly lack of sleep, I think) while I was waiting for my order of modafinil to be shipped/delivered and wasn’t expecting to get help with my sleep (I had also read the opposite to be true for some people) but as luck would have it, first day I took it I had my first 8:5h of uninterrupted sleep (in a long time) then same the next and the next. So, to me the help with sleep seems like a side effect LOL but a good one.
The other positive I notice is that it has helped me with inflammation quite a bit also, plus I used to have tense muscles mainly upper shoulder in my back and neck, and they are totally relaxed now.
Hard to explain other than I absolutely love the feeling. It is almost same as marijuana (indica type the one that sedates you) but without the nasty side effects, i.e. grogginess after the fact, the headache etc…
I tend to think that for some people it may not have any significant effect but from what I remember from a while back I think it would be a great addition for @Beth and @CronosTempi and some other people that are highly alert at night, sort of the types that are ADD or almost so.
You are exactly the type of person that motivated me to start this topic matter. Taking 3 diabetic meds when you don’t have diabetes, and nobody is monitoring this. There is no significant evidence that Metformin is of any benefit to a non diabetic. And yes, it is a mitochondrial poison.
It’s hard for me to find evidence for any of the prescription medications you take. I’m not sure whether to call LDN a prescription medication because of the dose. Hopefully you don’t get any serious side effects.
Thanks for the response and so far, so good, no side effects that I can tell and I’m monitoring blood markers carefully twice per year. My FG moved from high normal 98-104 to 81-84 as result of three diabetes meds I take. I’d prefer it in low to mid 70’s.
Interesting you say that because everything I’ve read about it says the opposite that metformin is good for mitochondrial function, maybe a little bit of poison here and there doesn’t hurt LOL
“The gold standard for the treatment of type 2 diabetes is metformin, which has a beneficial impact on the mitochondrial metabolism”
Metformin, primarily used for managing type 2 diabetes, shows promise as a life extension drug due to its ability to activate cellular pathways that may inhibit aging and promote longevity.
Mechanisms of Action
Metformin works by activating AMP-activated protein kinase (AMPK), an enzyme that plays a crucial role in cellular energy homeostasis. This activation has several beneficial effects, including:
Improved Insulin Sensitivity : By enhancing the body’s response to insulin, metformin helps regulate blood sugar levels, which is particularly important for individuals with diabetes.
While metformin shows significant potential as a life extension drug, further research is needed to fully understand its effects on human longevity. The ongoing studies, particularly the TAME trial, will provide more definitive answers regarding its role in promoting healthy aging
