Astaxanthin, Natural vs. Synthetic - Your Thoughts?

[Olafurpall]

@SolInvictus

Comments from one of the distributors of this astaxanthin suggest that the ITP dose achieved much lower blood levels in mice than the dose may suggest. Using high bioavailability astaxanthin, a dose of around 12mg to 24mg would achieve comparable blood levels in humans.

I wouldn’t trust what a distributor said. They likely want you to think you can achieve the doses in the ITP. Did they measure astaxanthin levels in the blood of the mice in the ITP study? If not it’s not possible to say with confidence that the astaxanthin used in it was low bioavailability. When I spoke to Richard Miller about the dose of the astaxanthin being so highh he mentioned nothing about the bioavailability being low, so if it is he would have been unaware of that, which seems unlikely.

@SolInvictus

I suspect the female mice might have had the astaxanthin diluted in fat tissues, since they have more fat than male mice, reducing effectiveness somewhat.

I doubt it. Male mice are not only heavier but their body fat percentage is not much higher than that of female mice. In many strains it’s higher than in females. Forty mouse strain survey of body composition - PubMed

[SolInvictus]

I think I heard there were blood tests on mice unpublished prior to ITP trials.

also are ITP mice inbred? I thought they weren’t. And I suspect more normal mice should have higher fat on females.

[Olafurpall]

Let me know if you find a source of that info.

[SolInvictus]

Currently we only have the distributor’s word. If you can contact paper author again, that would corroborate or refute the distributor’s claims

Your Brain on Astaxanthin : Can It Reverse Aging? (Brands Included!!)

It was mentioned here

I also emailed them and they commented as much. Blood levels from unpublished study prior to ITP showed blood levels from the chow with megadose similar to those seen in humans with reasonable astaxanthin doses.