Yes, I stand corrected on that point. I responded to Kawaii above.
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There is no direct evidence that liposomal ca-akg has higher bioavailability than regular ca-akg. However, there is lots of evidence with other substances that liposomal delivery increases bioavailability, so I have been taking the liposomal form of ca-akg on the assumption that it is giving me greater bio-availability.
The paper you cited is the first paper I have seen to suggest that excessive levels of akg can have a harmful effect. It makes sense though, because akg is thought to act partly via hormetic mechanisms, so too much of a hormetic substance could be harmful. Too much of any substance is harmful.
I take 600 mg of lipo ca-akg, a modest dose that, even accounting for potential increased liposomal bioavailability, is still within range of studied doses.
The CEO lacks academic rigor ā¦ MA her terminal degreeā¦ at a mediocre state college.
I trust TruMe Lab Longevity PhD Yelena Budovskaya more same with GlycanAge Prof Gordon Lauc.
I believe thhese 3 tests do tell a lot about your biological age health.
A google scholar search will show you dozens and dozens of papers on alpha ketoglutarateās benefits for health. Even if it has no benefits for lifespan, I think the evidence for increasing healthspan is strong.
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C44&q=alpha+ketoglutarate&btnG=
For lifespan, we have the following studies in animals, not counting the recent ITP study.
https://pubmed.ncbi.nlm.nih.gov/32877690/
https://pubmed.ncbi.nlm.nih.gov/31820364/
https://pubmed.ncbi.nlm.nih.gov/24828042/
https://pubmed.ncbi.nlm.nih.gov/26190651/
https://pubmed.ncbi.nlm.nih.gov/25643626/
https://pubmed.ncbi.nlm.nih.gov/31242135/
There is also a recent paper on akgās role in delaying stem cell senescence.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00688-6
I see ca-akg as something that is generally safe, is very likely to give healthspan benefits, and may increase lifespan. It also has a mechanistic basis to extend lifespan via cellular TET enzymes and JMDJ enzymes. Its also affordable, so I think it has a very good risk to reward ratio. At least worth taking for a few years while doing lab tests to measure effects.
Would be great to have more research, but there is very little financial incentive for companies to conduct expensive human clinical trials with these natural compounds, so we have to do the best with the data we have.
The CEO of Trudiagnostic is a man, Dr. Matthew Dawson. He received his MD from the University of Kentucky College of Medicine, which is not one of the top medical schools in the nation but is still well ranked and very hard to get into. I donāt like to judge people by the ranking of the school they attended but rather the quality of their output. Dr. Dawson has co-authored two medical textbooks and has published dozens of peer-reviewed scientific articles. His company has collaborated with leading geneticists at Harvard (for the creation of OmicAge) and Yale (for the creation of SymphonyAge). I havenāt seen anything to suggest that he or his company are untrustworthy.
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Youāre correctā¦ but is the co-founder Hannah Went that lacks academic depth and rigorā¦ so much soā¦ that she doesnāt list her terminal degree as a so so Masters. Money focused ā¦ and having multiple conversationsā¦ she comes off arrogant and bitchy. Mis-naming me multiple times from the word hello despite multiple correctionsā¦ not Jamesā¦ having paid a consultation fee. Noā¦ I am not impressed with her at allā¦
Counter that with Stanford Professor Dr. Yelena Budovskaya and Washington University Dr. Kaeberlein who both have done decades of deep research and making a difference in Healthcare. To compareā¦ unpaid, they know who I am by correct name and we have had both fun, but also deep dialog. I have had wonderful conversations and text conversations with them.
So my critique is the co-founder.
People can pick their mentors. Not my concerrn.
Love how Matt always manages a zinger on Dr. David Sinclair when it is mentioned they worked togetherā¦ Matt K. ā¦āHe (David) says some things that are true!ā 
Brilliant ā¦ but a con artist too. Not a fan of TruDiagnostic or its administration.
Hannah Went is the co-founder of TruDiagnostic, a leading health data company and CLIA-certified laboratory specializing in epigenetic testing, biological aging clocks, and methylation-based diagnostics. [1]
About Hannah Went
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Background: She is a molecular biologist who graduated from the University of Kentucky.
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Early Career: She previously worked as the Director of Research and Content for the International Peptide Society.
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Current Roles: Along with co-founding TruDiagnostic in 2020, she is the founder and host of the Everything Epigenetics Podcast, where she interviews physicians and researchers about gene expression, longevity, and health optimization. [1, 2, 3]
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About TruDiagnostic
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Focus: The company provides advanced laboratory assays that measure DNA methylation to determine biological age, cellular health, and disease risk. [1, 2]
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Partnerships: It collaborates with major academic institutionsāincluding Harvard, Duke, and Stanfordāto develop multi-omic biological age clocks. [1]
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Mission: It primarily serves functional and integrative medicine healthcare providers to help personalize patient care and track wellness interventions. [1, 2]
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You said āLove how Matt always manages a zinger on Dr. David Sinclair when it is mentioned they worked togetherā¦ Matt K. ā¦āHe (David) says some things that are true!ā Brilliant ā¦ but a con artist too. Not a fan of TruDiagnostic or its administration.ā
What does Dr. Sinclair have to do with TruDiagnostic? I am not aware of any connection between them.
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Jesus! My experiences with Hannah Went was pure con without brillance. Ok? My N=1. Thatās it. You like her and her productā¦ great!
Move along.
I have.