Interesting discussion about epigenetic clocks, in the context of hearing loss.
" Our results suggest that not all commonly cited epigenetic clocks may correlate with sensory function. Although these clocks have been shown to be associated with mortality, as well as physical and cognitive function, they may not capture the same aspects of aging (Oblak et al., 2021). The epigenetic clocks were constructed using different phenotype information in populations of varying ages. Previously it has been observed that the correlation between clocks is not always strong. Indeed, among BLSA (Baltimore Longitudinal Study of Aging) participants who are typically healthier than general population, we observe younger epigenetic age (Hannum clock, Horvath clock, GrimAge, and PhenoAge) but the mean epigenetic measurement of pace of aging is 1.02, a value consistent with slightly accelerated aging. One potential explanation is that many age-related functional and phenotypic changes in fact accelerates at mid-to-late life, which the pace of aging may be unable to acknowledge because this epigenetic measure is established using only young adults ([Belsky et al., 2020]"