My point is what are you using it for? As far as I can tell there are two forms of sodium hyaluronate, high molecular weight and regular or lower molecular weight than hyaluronic acid.
So, if you are using it externally the choice is what are trying to do.
“Hyaluronic acid has a high molecular weight, which means it’s a macromolecule. The large molecules coat the skin and prevent water loss, leading to better hydration.”
“Sodium hyaluronate has a lower molecular weight than hyaluronic acid. It’s small enough to penetrate the epidermis, or top layer of the skin.”
“Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance and possibly to the longevity of the longest-lived rodent—the naked mole-rat. To study whether the benefits of HMM-HA could be transferred to other animal species”
“they successfully transferred a gene responsible for making high molecular weight hyaluronic acid (HMW-HA) from a naked mole rat to mice.”
If a supplement or drug could achieve the same results, why didn’t they just do that?
It has been shown in studies that hyaluronic acid supplementation in the form of sodium hyaluronate may reduce skin wrinkles.
Personally having spent more money than I wanted to on hyaluronic acid supplements, I still have two bottles of the liposomal form, I did not detect any significant benefit.
The body of course generates its own hyaluronic acid, and in the study, they successfully transferred a gene responsible for making high molecular weight hyaluronic acid (HMW-HA) from a naked mole rat to mice.
If hyaluronic supplements, which have been around for many decades, had any life extension or anti-cancer properties in humans, I am sure they would have been noticed by now.
“Hylaluronic acid engrafted metformin loaded graphene oxide (HA-GO-Met) nanoparticles
exhibited an anti-cancer efficacy”
What we need is a gene transfer from a naked mole rat.