Amount of Central Fat Predicts Mortality Risk in Non-Obese Individuals

#113

A team of Japanese researchers has discovered a powerful synergy between gut bacteria and an acetate supplement called AceCel that helps mice lose fat without losing muscle.

When combined with specific Bacteroides bacteria, acetate rewires metabolism, boosting fat burning and reducing sugar availability. This mechanism mimics fasting or a keto diet and could pave the way for new functional foods to fight obesity in humans.

Acetate and Gut Bacteria: A Surprising Duo Against Obesity

A team of researchers in Japan, led by Hiroshi Ohno at the RIKEN Center for Integrative Medical Sciences, has uncovered an exciting new approach to reducing obesity. Their study shows that giving the gut extra acetate, a natural compound, can lower both fat and liver mass in mice. But there’s a catch: this effect only works when specific gut bacteria called Bacteroides are also present. When these bacteria and acetate work together, they help the body burn more fat and remove excess sugars from the gut. The findings were recently published in Cell Metabolism.

Obesity is a major global health issue, affecting hundreds of millions of people. It is often linked to high intake of sugar and starchy foods and increases the risk of heart disease, type 2 diabetes, and cancer. Interestingly, eating fiber has been shown to reduce the risk of these very same diseases. Although humans cannot digest fiber, it reaches the large intestine where it is fermented by gut bacteria. This fermentation produces byproducts, some of which enter the bloodstream and help regulate metabolism.

https://scitechdaily.com/forget-keto-this-fiber-fueled-gut-trick-helped-mice-melt-fat-fast/

Paper:

Acetylated cellulose suppresses body mass gain through gut commensals consuming host-accessible carbohydrates

by Tadashi Takeuchi, Eiji Miyauchi, Yumiko Nakanishi, Yusuke Ito, Tamotsu Kato, Katsuki Yaguchi, Masami Kawasumi, Naoko Tachibana, Ayumi Ito, Shu Shimamoto, Akinobu Matsuyama, Nobuo Sasaki, Ikuo Kimura and Hiroshi Ohno, 16 May 2025, Cell Metabolism .
DOI: 10.1016/j.cmet.2025.04.013

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#114

I’m interested. Where can you buy AceCel?

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#115

hmmm… doesn’t seem that anyone has really commercialized it yet, mostly available from chemical supply houses:

From google Gemini:

You can purchase acetylated cellulose (also known as AceCel or cellulose acetate) from several sources, including online retailers like Amazon.com and scientific supply companies like Sigma-Aldrich. Additionally, chemical suppliers such as Spectrum Chemical and Alfa Chemistry offer cellulose acetate in various forms and quantities.

see Amazon listing below:

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https://www.amazon.com/Cellulose-Acetate-9004-35-7-Purity-35-3/dp/B0BXNNK93S

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#116

Just checking on the toxicity of this substance and it seems fine…

what is the human LD50 for Acetylated cellulose

ChatGPT said:

There is no established human LD₅₀ (lethal dose for 50% of the population) for acetylated cellulose (also known as cellulose acetate), primarily because:

  1. Cellulose acetate is generally considered non-toxic.
  2. It is widely used in medical devices, pharmaceutical coatings, food packaging, and cigarette filters, which implies low acute toxicity.
  3. Animal studies typically show very high LD₅₀ values, often not reaching a lethal dose at tested levels, meaning toxicity is minimal or absent at realistic exposure levels.

Regulatory and Safety Assessments:

  • Oral and dermal exposure to cellulose acetate is generally regarded as safe.
  • It is not classified as hazardous under most regulatory systems (e.g., OSHA, GHS).
  • The material is not readily absorbed by the body and tends to pass through the gastrointestinal tract unchanged.

Conclusion:

There is no published human LD₅₀ for cellulose acetate because it is not acutely toxic in the doses that humans would reasonably be exposed to. It is classified as having low to negligible acute toxicity.

If you’re looking into a specific form (e.g., low vs high acetyl content, or additives in a formulation), let me know, and I can help further.

1 Like
#117

I like the Japanese. It seems like they come up with great technology for health. Unfortunately, it seems as if it rarely becomes mainstream. I wonder if this is due to a lack of profits seen by companies?

#118

My choice to swap from semaglutide to tirzepatide was that I heard the GIP component of tirz helps actively burn visceral fat.

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#119

Have you managed to lose your percent fat? I’ve gained about 7 kg the past few years, most of it fat it seems, but still actually optimal BMI. I tried tracking food in an excel spreadsheet (kcal/protein) for awhile and it seems to work.

What I’m noticing is that to get enough protein according to the protein bros basically the only thing you can eat is lean protein, vegetables, maybe 50-100 grams of whole grains or slightly more, one or two fruits, and very slight amount of fat.

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#120

I’m going in for a Dexa scan soon so I’ll get back to you on that, but I think it’s working. I’m taking an approach very similar to yours… but avoiding most wheat products. s

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#121

Anybody figure out how to buy this yet?

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#122

Cellulose acetate should be dirt cheap due to all the industrial uses for it.

https://www.alibaba.com/product-detail/Cellulose-Acetate-Cas-9004-35-7_1601228304406.html

#123

Acetogenic fibers - 6:00

Acetogenic: can be fermented by gut bacteria into acetate - 6:21

Inulin -Chickory root, Jerusalem artichokes, onions, garlic, leeks, asparagus -6:26

8:19 Metformin has consistently been shown in animal studies to increase Akkermansia muciniphilia.

8:43 Rhubarb extract has shown some promise in pre-clinical studies for increasing Akkermansia muciniphilia levels.

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#124

Kill the visceral fat before it kills you! Get your DEXA scan now to check your visceral fat levels!

Hidden organ fat speeds up heart aging, while fat around the hips and thighs in women may slow it.

Large amounts of visceral fat, the hidden fat that collects around internal organs, have been linked to a quicker aging process in the heart, according to new research.

While aging is the primary risk factor for heart disease, scientists still do not fully understand why some individuals experience faster cardiovascular aging than others. The team behind this study suggests that visceral fat may be a key contributor, speeding up the aging of both the heart and blood vessels. Although this type of fat has long been associated with negative health effects, the findings provide fresh evidence that it may specifically drive premature heart aging.

Published in the European Heart Journal, the study examined data from 21,241 UK Biobank participants. This resource includes whole-body imaging, allowing scientists to measure not only the total amount of fat but also its distribution across different parts of the body.

Measuring Heart Age with AI

The UK Biobank data also includes detailed imaging of the heart and blood vessels. Artificial intelligence was used to analyze these images to capture signs of organ aging – such as tissues becoming stiff and inflamed. An individual was given a “heart age” which can be compared to their actual age at the time of the scan.

The researchers found that faster heart aging was linked to having more visceral adipose tissue. Visceral adipose tissue is fat found deep inside the abdomen around organs such as the stomach, intestines, and liver. This type of fat cannot be seen from the outside, and some people can have large amounts of visceral fat despite having a healthy weight.

The researchers found signs on blood tests that visceral fat is linked to increased inflammation in the body – which is a potential cause of premature aging.

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Open Access Paper:

Sex-specific body fat distribution predicts cardiovascular ageing

https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf553/8237967#google_vignette

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#125

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https://x.com/real_lord_miles/status/1962885255251055096#m

Blood test recently:

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https://x.com/real_lord_miles/status/1962246098187428102#m

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#126

This will be interesting to pay attention to. I certainly would never do this but I’m always up for observing a unique experiment.

Reminded me of this guy.

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#127

Angus Barbieri lived to be only 51 years old.

He lost a lot of weight fast, but it didn’t help him live into old age. He died younger than many obese people who remain obese. I guess this is an example of fasting that didn’t pan out for longevity.

Tragically, he died at the young age of 51 in September 1990 after a short illness.
His father, Joe, briefly outlived his beloved son and died at the age of 94. It was a tragic footnote to an incredible story of human endurance.

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#128

I recently watched the True North guy on the Diary of a CEO podcast. This was not his most interesting interview I’ve seen, but this was by far the most recent.

When I say not interesting, I only mean they didn’t talk about the wild cases of someone being in chronic pain etc and giving up hope and how the long fast magically cures them.

They max out their water fasts at 40 days, and when going that long, it’s important to do it under a doctor’s supervision. He also notes it’s important not exercise during a long fast.

#129

I would imagine the illness was not related to the weight loss. He became ill after he broke the fast and started eating again, so that tells me they are both separate things.

#130

51 is awfully young to die. It doesn’t appear that the fasting helped him live longer.

#131

Yes but what I’m saying is that he probably would have still gotten the illness if he remained obese, so we will never find out if it was going to help him live longer since the illness stopped him in his tracks.

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#132