Amylase is secreted into the small intestines by the pancreas. Alpha-glucosidase enzymes are located in the brush border of the small intestines. Amylase breaks down the carbohydrates into oligosaccharides. The glucosidase enzymes (including lactase, maltase and sucrose) complete the breakdown to monosaccharide units
It’s testable with CGMs too. Also, are white beans (either cannellini or broad beans) a sufficient source?
It seems that it only works on the more complex polysaccharide chains, so it would not work on sucrose? (acarbose works more on this)
In the first study, a placebo-controlled, cross-over study, eleven fasting subjects (men and women aged 21 to 57) were given 4 slices of white bread and 42 g (3 Tbs) of margarine with or without 1500 mg of Phase 2 (the Phase 2 was added to the margarine) . The food contained a total of 610 calories, 60.5 of which came from carbohydrate. The tests were administered a week apart. Absorption and metabolism of carbohydrate was measured as levels of plasma glucose over time. In comparison to control, the glucose levels following consumption of Phase 2 returned to baseline 20 minutes earlier. The area under the plasma glucose vs. time curve was 66% lower with Phase 2 compared to the control (p < 0.05). The authors concluded that this indicated that 1/3rd of the carbohydrate in the bread was absorbed. However, actual absorption and subsequent excretion was not measured.
I haven’t looked deeply into this yet - they may be using SUPER-FAULTY logic in saying “AUC 66% lower => 1/3 of the carbs was absorbed” [b/c obvs insulin makes this a non-equation]
For type 1 diabetics, levels of α‐amylase have been found to be double that of non-diabetics, though it is unclear why. Since most type 1 people don’t consume many simple sugars, an α‐amylase inhibitor makes a lot of sense in order to counteract the complex carbs they do consume. I’ll give it a try at 3g powder per meal.
I will have to try an experiment with my CGM. This only works on more complex carbs, but lol, I will do the evil thing and eat bread… But first, before I do the evil thing, I’ll try it on beans + CGM myself.
Also the effective dose (2000mg) is way higher than the effective dose of acarbose.
It is MUCH easier to get than acarbose which is a strong point in favor of it. You can even get it from CVS/Target (though the Amazon version is better)
That’s interesting if you can compare the efficacy dose of Alpha-amylase inhibitor and Acarbose, and also the combination of Alpha-amylase inhibitor and Acarbose to see if there is a synergistic effect.