Alex K. Chen metabolic / CGM progress (my "everything in longevity" thread)

Have not tried yet.

Tbh I overslept last night (dreamed A LOT about obsessing over the climate of Arizona and Palm Springs under the worst cold wave possible) and was very very slow to wake up. BG is at 62 now and I’m surprisingly functional.

I do not know if I’m fully on keto yet, but when I use the proper stimulants, I’m alert enough now even when hypoglycemic, and most importantly I don’t crave large amounts of food/vegetables like I used to. If this holds, this is the most important thing, because it then means I can drastically reduce the amount of time and money I spend on food, and drastically reduces my blood glycation levels. It MAY even reduce my sleep need (this is the most important thing from fully-keto-adjusted people), but I have not seen this yet (and I overslept last night)

Also, weed takes some of the “unpleasant peripheral” edge off nicotine…

Melatonin drives down glucose. It can be used during the day, but could have weird consequences.

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What makes you say that?

Watching the effect on glucose of taking melatonin as i have said in other threads. I would not necessarily use it during the day without some further research, but some people do.

Also

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It increased after waking even though I didn’t eat anything

Ate 1 box of beyond sausage (1000 calories), then 1 box of Lily’s chocolate (450 calories), then 7 packs of konjac jelly (god it goes down so much). Tbf I didn’t feel great earlier today and felt better after being more alert on the jelly.

I also just drank KetoneAid performance-enhancing drink.Going to test this again tomorrow and other days.

I’m not sure if I will feel better on ketosis, and (people go through keto flu where they feel unpleasant for MANY days). Maybe I would have a mild keto flu in the transition, but it is impossible to try, and I wonder if external incentives will make me end up not keto’ing.

All I know is that I managed to suppress appetite enough that I don’t feel like I need to feel my stomach up. Oat fiber is SO bland but it made me feel “full enough” yesterday (enough that my BG went down to 44 for a while)

Honestly I felt poorly today. I got over my new years
Sadness.

Also I still ate over 2000 calories in the end

It’s way easier to function when I just have beans AND WHITE KIDNEY BEAN EXTRACT (which might reduce calorie consumption). The experiment was worth it bc I never saw my BG that low. I need beans

I got a new keto ester and tried it today but it didn’t make me feel better

I also just HAVE to finally test my white kidney bean extract on a falafel sandwich for once

ate more almonds + chocolate today and felt terrible after. it was 450 calories of chocolate.

this went way over my calorie intake. I was too hungry. But too much chocolate is LDL cholesterol and that’s BAD.

I can feel bad after eating fats, not just carbs). Also my BG went up to 105 for a while. Which might have been enough to kick me out of keto

I still get hungry too easily. I am not hungry for much of today and hopefully can stay that way (idk if it will). I don’t calorie-restrict enough.

But I’ll still try to continue with high-fat, low-carb for now.

Have not had enough appetite for veggies/mushrooms

felt terrible for today b/c of the fat bomb. i ate two entire chocolate bars yesterday.

weight still dropped to 94.8 lbs

my avg blood glucose now has been surprisingly high (90s) despite not eating carbs for much of the day. This is consistent with low insulin/ketosis (in ketosis, insulin is so low that when BG hits 105, it stays at 105 for A LONG TIME rather than decrease). In fact, ppl in ketosis tend to have average BG not much different from those not in ketosis (they have WAY less variability, but on avg it’s slightly higher than high-carb, low-fat)

I think the major advantage of ketosis is that it lets you get by with less sleep. If not for that, ketosis probably isn’t super-worth it. Also you’re less affected by hunger (but I was affected by hunger yesterday)

have not confirmed ketosis state, but it could be rn, idk

I’ll try it for a bit longer and see how it goes.

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drank macademia milk, I went to supermarket and bought marinated mushrooms + extreme bean + pecans. to my surprise I seemed to get full much earlier than I ever get used to (like normally I wolf down entire packages of nuts and NOT this time). i initially had cravings for beyond sausage but they ended when i came to store so i didnt need them!! everything TBD over next few hrs tho

feeling very alert today after afternoon sleep.

ate watercress for the first time!

BG has been super-steady the past 5 days (it takes roughly a week for keto adaptation I should aim for that)

pecans, beyond meat, chocolate, nut milks, watercress, chard, bok choy, marinated mushrooms => now there is no excuse (other than social reasons) for not doing keto. I do eat high-volume so keeping minimal carbs should be painless enough with the right choice of foods - enough that I can avoid higher-carb veggies/nuts like carrots/almonds

Wow for keto the max protein guideline is literally just 1.6454 equals 288 calories of protein per day for me max. That is REALLY HARD and one entire tofu could take me over wow…

Vegetables alone have protein too

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I just discovered https://longevity.technology/news/back-to-biology-eric-verdin-talks-nmn-and-longevity-supplements/ today. Last time, NR did not boost my NAD+. but NMN is one step closer so I’ll try.

I’ve been reading through everything posted by Eric Verdin. My BG levels now (after a week of very low carb) are lower and steadier than ever before. Eric Verdin’s research is very validating whereas there used to be very little research on keto. But it also shows that keto probably isn’t going to produce major gains in life expectancy. Also, mice overeat on keto (aka it doesn’t decrease appetite that much), and he has used alternating keto (mice lose weight VERY quickly after 2 days of fasting so maybe the “keto incubation period” is shorter for mice than people).

I’m going to continue to avoid high-carb foods, but it isn’t practical to continue to avoid super-healthy food just b/c if has carbs in it. I’m also not as emotionally damaged as I was 1.5 weeks ago.

This is what one bag of cauliflower rice (20g carbs)

And a small handful of blueberries did

related: Nutrients | Free Full-Text | Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis (they didn’t even report
glucose levels…) let me ask the author. same person behind Ketone drink could help diabetics by lowering blood sugar -- ScienceDaily

Interesting it goes back to below normal, I wonder if it is BHB

I was hyperalert and reading lots of hard research papers in the very early hours of the morning despite hypoglycemia. Then super-tired (mental exhaustion) and slept a few hours and only watched videos on the Imjin War and Battle of Monte Cassino (yeah military history is totally my weakness…)

Am very very very slow to get alert late today though m not keto adapted yet

Ate a small handful of blueberries late today with little impact on glucose. Am not mentioning my high fat meals bc they definitely don’t affect BG

I want to understand ketosis better because it is WAY easier to do than CR and it might give just the same benefits (this is unknown, I still need to understand the papers better).

Even after berries

I think I can self limit calories even with fewer vegetables if I eat more from olives and nut milks and chocolate (knowing that I will always overeat nuts/avocados)

I did a huge amount of research on 90th percentile mice lifespan curves today I can’t believe I never bothered till today. Esp interested in the keto mice (they live longer but not as long as rapamycin + metformin mice but srsly NO ONE has combined keto, rapamycin, and metformin)…

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I think driving my average BG down from 90 to 70 is a huge deal, whether or not I fully succeeded at keto.

Rapamycin+metformin+keto has never been tried but super-worth trying. Bryan Johnson is KIND of in this direction.

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My G7 fell off at 3am this morning, but I thought I would put together a comparison from Feb/March 2022 with my current glucose handling. Some extracts are above. The first charts are from a G6 and the second from a G7. I am not quite sure of the absolute values. My breakfast has been consistent for a number of years (at least during the working week) and it does include two slices of toast and some other carbs. What I see is that my current glucose handling runs in a much narrower range of blood sugar (multiply by 18 for the other units) than it was doing in early 2022. I had seen that in a really low HbA1c (4.18% on one test), but I can see from this that I have made progress.

Wow, 4.18% HbA1c is so good.

BHB also decreases glucose level (Eric Verdin says this and uses this to advertise his BHB esters). Eventually they will become cheaper. They are worth testing. I think getting keto-adapted (or adapted to fat-burning) first is important (this can take a few weeks). But I don’t know if I want to do keto forever, b/c it means missing out on so much legitly healthy food.

BHB is most of the benefit of keto and it can be exogeneously supplemented, but I don’t know when BHB will become as good as endogenous keto, esp b/c administering BHB to your cells will not force your cells to be fat-adapted/not so addicted to carbs.

“fat adaptation”, an intervention in which well-trained endurance athletes consume a high-fat, low-CHO diet for up to 2 weeks while undertaking their normal training and then immediately follow this by CHO restoration (consuming a high-CHO diet and tapering for 1-3 days before a major endurance event). Compared with an isoenergetic CHO diet for the same intervention period, this “dietary periodization” protocol increases the rate of whole-body and muscle fat oxidation while attenuating the rate of muscle glycogenolysis during submaximal exercise. Of note is that these metabolic perturbations favouring the oxidation of fat persist even in the face of restored endogenous CHO stores and increased exogenous CHO availability

2 weeks (even avoiding beans and most carrots), it is not so hard. It is too bad that most bags of frozen vegetables have carrots in them.

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That was only in one test. (and I picked the best one). Also there are two types of HbA1c the aldimine and the ketoamine. Some tests only report the ketoamine (I think the immunofluoresence analyzers).

Still when you look at the glucose handling there are hardly any high peaks now it tends to run in a 3 mmol/l range.

hba1c

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Ok so your estimated average glucose is 73. eAG/A1C Conversion Calculator | American Diabetes Association

That’s pretty good, and you don’t seem to be in ketosis.

  • 3.9 mmol/L = 70.27 mg/dL

Holy shit I just discovered this

https://www.safeway.com/shop/product-details.107150014.html

165 calories per CAN of olives (or 1 calorie/gram of olive). This is the lowest I’ve seen anywhere.

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Also, after getting a REAL water filter, I am much less reluctant to drink water (yes, microaggressions like that) and this probably will help me reduce calorie consumption long-run. I do drink lots of nut milks, but it’s nice to have something other than nut milks, esp b/c I specifically filter microplastics out of this.