Car crashes don’t last very long either but they can certainly cause a lot of damage. I view glucose spikes in a similar yet obviously not as severe fashion.
I believe the biggest advantage of Acarbose is the SCFA production. Instead of having your gut microbiome convert carbs into sugar, you are having your biome turn the carbs into SCFAs which are cardio and Neuro protective and also reduce blood pressure.
Yes - I think that may have traditionally been thought to be the case…
But the NIA ITP studies with Acarbose and Canagliflozin seem to indicate otherwise (though by no way is the case closed, I think). The fact that Acarbose and Canagliflozin are so successful in lifespan extension while lowering blood glucose spikes via different mechanisms, suggest that the blood glucose spikes are harmful.
The massive quantities of dietary fiber I tolerated in my 40s and early 50s weren’t working so well in my late 50s but everything is fine now that I am taking digestive enzymes. I’m getting around 50 g fiber/day with about 1500 kcal/day.
Using a geroscience approach to mitochondrial disease, we expose a connection between neurological mitochondrial disorders and the intestinal microbiome
Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome
The findings of this study suggest that acarbose can reduce serum levels of TG and TC. However, no significant effects were observed on LDL or HDL levels.