Acarbose - Dosing, Use, and Buying Experiences

[Hackingbiology.com]

100mg in the morning (no breakfast, without food)
100mg in the evening (at dinner time, with food)

Doing 1 meal a day.

[macneu2299]

What’s the purpose of taking Acarbose without food?

[Neo]

@macneu2299 see for example (click each link to get correct formatting):

Acarbose for healthy person? WHY?

Would also look into these reasons mTORC2 and gut microbiome: the lifespan of male mice is extended ***by acarbose *** and 17α estradiol, and these compounds increased hepatic mTORC2 activity Is there a way to selectively upregulate Mtor2 while on Rapamycin? - #6 by Neo (And some posts above and below) Acarbose’s longevity capabilities is not only from preventing blood sugar spikes after meals I think. Probably more important is its gut microbe effect. The increase of butyric acid is noticeable after very short usage, and other SCFA’s for that matter. There is a reason why almost all centenarians has very healthy guts, it makes you live longer and healthier. Acarbose - Details On Another Top Anti-Aging Drug - #51 by Goran (Other posts on the forum about that)

And

Acarbose for healthy person? WHY?

And here is summary by one of the providers (so you should verify anything you might rely on yourself) The Longevity Mechanisms of Acarbose 1. Regulating Glucose Spikes—Reducing ROS Acarbose works by blocking an enzyme called alpha-glucosidase, which helps digest and absorb carbohydrates in the small intestine. By inhibiting this enzyme, acarbose slows down the digestion and absorption of carbs, which can help regulate blood sugar levels and prevent spikes in blood glucose. In studies of diabetes patients taking acarbose, we have observed an absolute decrease of 0.7% in HbA1c levels, which translates to approximately a 10% reduction in typical HbA1c values for diabetes patients. This reduction in blood glucose levels has a profound impact on longevity. As we age, our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line ou…

[cl-user]

@macneu2299

What’s the purpose of taking Acarbose without food?

None. It’s not absorbed into your body. It’s an alpha-glucosidase inhibitor which means it inhibits the enzyme that breaks down the complex carbs into monosaccharides like glucose so it’s only useful if you eat complex carbs. It does not do anything on simple sugars like glucose or even some carbs like lactose for instance.

When you eat carbs along with acarbose, they are not broken down into glucose so they are passed to the bacteria in your gut that can feed on them (hence the gaz potentially).
A simplified view is that this has basically transformed the regulars carbs like starch into soluble fibers.

[Almostthere]

Hi, I am US citizen moving from Bangladesh to Colombia. I will pass through the states once or twice a year for a few weeks at a time. I will not have US health insurance. I do not believe acarbose is commonly available in Colombia. Any advice on sourcing it? Any thoughts would be appreciated.