Metformin and rapamycin seem to work well together. They counter each others negative points. I think that is why the combination to worked better in the ITP study given that Metformin failed on its own.
I was taking Metformin before I started rapamycin. My point is that rapamycin did not make my blood sugar worse. I have added acarbose but given my sourcing issues I use it very sporadically.
Rapamycin pseudo-diabetes is not benevolent and should be addressed. There is a mouse study where diabetic mice taking Rapamycin had their diabetes worsened and they ended up dying earlier than the control. Rapamycin aggravates diabetes and can shorten your life if your diabetes is not under control. The mice taking Rapamycin with diabetes died from inflammation caused by the Rapamycin making their diabetes worse. Do not take Rapamycin if your blood sugar is not under control. You may die earlier. Metformin or acarbose can help get your blood sugar under control. I am getting my prescription for acarbose as I write this.
Thank you,De Strider,My current blood sugar levels are normal. If I start taking rapa and my blood sugar rises to prediabetic levels, how should I manage it? Should I stop taking the medication and observe, or add acarbose to my treatment plan?"
Canagliflozin, acarbose and Metformin are all potential treatments for high blood sugar. It’s up to you which you would prefer. I personally will be using acarbose and Metformin. I may use canagliflozin at a later time but it may be overkill at this point.
SGLT2 inhibitors can be used in low dose intermittently (e.g. every other day, three times a week…) with good results in diabetics so this can be an option. I picked up some empaglifozin some two weeks ago, but still contemplating using it. From what I read it is a better option than metformin, as SGLT2 inhibitors are CVD and kidney protective and there is some evidence on improving/protecting against cognitive impairment.
I believe I had some symptoms of high blood sugar after raising my Biocon dosage to 8mg with fats. An urgency to urinate that had me plotting how to arrange my day so I was never 60 minutes from an bath room. I didn’t have strips to measure blood sugar but the symptoms were new and strong. I stopped Biocon and the symptoms disappeared after a few weeks and travel to the tropics (got loads of sunshine vit d).
I have my strips now and found that 2mg of Biocon (with grape fruit) had the following morning blood levels about 10mg/dl higher than normal.
So I am using Myo-Inositol - 1500 mg twice a day (total 3000 mg) and 500 mg IP6 once a day to control blood sugar. I took 2 weeks off from Biocon to free my system of rapamycin. Took the Myo-Inositol and IP6 and found it lowered my morning blood sugar 10 mg/dl below by normal reading. After 5mg Biocon, I found a small rise above my normal blood sugar levels the morning after, but the following mornings back to below normal levels.
My main goal with rapamycin use in the near future is to help with training for a sprint triathlon in August. Some have reported here about having better recovery and time goals in their athletic training and I have experienced that too I believe. I think a weekly medium dose of 6mg (with fats) and then stopping 4 weeks before the event will be a good strategy and one that seemed to work last summer (though with rapamycin from a compounding pharmacy).
If my morning blood sugar rises over time, I will drop dosage and extend time between taking. I am also more mindful of what I am eating on dosage days - fast most of the day with low carbs and low protein.
N=1, but am very happy with these results, albeit limited usage so far. I think the research literature is very robust on the efficacy of using Myo-Inositol for lowering blood sugar and blood lipids also. I can’t see why one would not choose it over acarbose, at least to start. Do a search on this site for myo-inositol. The following review article is a good synopsis also. Omoruyi FO, Stennett D, Foster S, Dilworth L. New Frontiers for the Use of IP6 and Inositol Combination in Treating Diabetes Mellitus: A Review. Molecules . 2020 Molecules | Free Full-Text | New Frontiers for the Use of IP6 and Inositol Combination in Treating Diabetes Mellitus: A Review
You could also lose body fat to become more insulin sensitive, eat less carbs, and do more high-intensity exercises, such as weight training, to use up the excess glucose. High-intensity exercises use more glucose whereas low-intensity exercises use more fat. Having lots of muscles and using them regularly provide the best protection against diabetes.