10mg Rapamycin - Persistent Hoarse Voice

[lin]

@kansel

Any side effect I ever had was always on lower doses such as 2-5mg’s and weirdly the lower the dose the higher the side effect occurrence.

That is indeed peculiar. I’m not sure what to make of your experience.

[RapAdmin]

@kansel

I get ZERO symptoms at higher doses of 10mg plus GFJ and EVOO.

A lot of the important side effects of high dose rapamycin (that some portion of the population will experience) are not something you would notice… lipid disregulation, glucose disregulation, immune system suppression, etc. can be very harmful, but not something you would notice. This is why its important to do regular bloodwork to check on all these factors if you are exploring anything above the typical 4 to 8mg per week dosing (and even then, monthly or quarterly bloodwork is a good idea).

[Olafurpall]

@kansel

In a nutshell though the Mtor inhibition in different part/organs of your body is triggered at different doses. Therefore, you’d have varying effects on low doses as opposed to higher.

This goes with all drugs. That doesn’t mean it’s somehow better or safer to take higher doses.

@kansel

In other words, in lower doses, you’ll have an imbalance of Mtor in your different organs, thus plenty of side effects. While at high doses all your organs and their mother get their Mtor inhibited (a very healthy and a good thing) thus your body thrives, and you have ZERO side effects.

This is where your logic falls apart. Higher doses wouldn’t just cause the inhibition to reach more significant levels in places where low doses wouldn’t cause significant effects, they would also potentially result in excessive mTOR inhibition in places where the low dose would not cause excessive mTOR inhibition. Therefore it makes no sense to think that the higher doses are healthier or have less side effects. In your case you may certainly notice fewer side effects at higher doses, but as RapAdmin pointed out, a lot of important side effects are not felt at all. In fact most side effects are not felt at all.

[stealle]

@hunterama1

I’ve had this slight hoarse voice since the first week which has rather progressively persisted and slightly worsened

Would be great to hear from @hunterama1 I hope he is OK…

[tfl.phd]

@RapAdmin

I remember reading somewhere in the forums that ,081 mg/kg for Rapamycin dosing is somewhat accurate. Can anyone confirm?

Of course the more accurate measurement would be to do a Sirolimus bloodtest, and measure the peak concentration etc…