Kind of hard on pre and probiotics, Rapamycin and sulforaphane. I think these things are more personal than universal. I remember the waterfall plots.
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I made a copy of the list and expect it to be a useful reference. Thanks for posting it.
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I have never felt any subjective benefits from pre- and probiotics, and I have tried a great many. Currently I am not taking them.
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spermidine is now “bad”? Just bought prescription amitiza… not sure I will go with that on this list (not that he says its harmful)
Probiotics somewhat helped me with bouts of indigestion and heartburn, but not anywhere near as much as getting off the piss.
I posted the list, but that should not be taken as agreement with the contents. I find these lists from different sources useful in the round, but I have my own assessments.
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Nice comprehensive list. I will also keep it as a reference. Looks like I’m already taking almost all of ‘God’ supplements and some of the good. Will switch to using wheat germ for spermidine.
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Realized a huge hack for my morning routine, drink electrolyte with tea first including creatine and glycine. Then coffee with collagen. Sets foundation for the day by helping to optimize BP (morning surge) and Glucose. A drop of honey too if you fasted long enough your glucose approaching low 4s.
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I though that a recent study showed melatonin is not good supplementation since is increases cardiovascular events
Haven’t been able to find the ranking methodology used here for this list (such as Delphi?). I do note that Siim Land’s personal preferences change the ranking of supplements, the tiers used are labelled judgmentally (a marketing technique), that he is an anthropologist, author and promotes commercial supplement discounts on his website. There appears to be a lack of consideration of effect size, Number Needed to Treat, or other indicators of the efficacy of the supplement for us humans. Given the above observations, I would personally think of this as a commercial exercise, rather than rigorous data, or an attempt at an evidence based medical ranking? A useful catalogue perhaps, but please use your critical thinking before parting with your hard earned cash.
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He’s a random influencer. What are his qualifications and why should anyone pay attention to anything he says? Life is short, and I personally see no reason to devote my time to providing him with clicks. YMMV.
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I posted this. I don’t agree with his list, but every time I see a list I like to look at it to see if there is something I have not heard of before.
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I would add Ursolic Acid - I started this a few weeks ago. Definitely feel more energy and less inflammation overall.
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I don’t know about his qualifications, though I think he is knowledgeable. He does a lot of research and self-experiments and publishes the results. “My Longevity Experiment charts my progress as I focus on the pillars of longevity.” One thing that strikes me is that he looks very fit and his skin is flawless. Maybe genes, but his supplement list isn’t harming him.
After watching one of his videos, I do my own research to see if his claims are valid. So far, I haven’t found any fault on his part.
He doesn’t seem to have a hidden agenda, unlike many of the YouTube health gurus. I follow health experimenters on YouTube as I do the self-experimenters in the forum.
I think his supplement assessments are right on. I have minimal disagreement with his assessment.
As always, do your own research and never take anything for granted, no matter who the health
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My own view of him is that he is OK. That does not stop him being wrong from time to time and I would not recommend Ashwagandha for example. There are people I would not copy to the forum such as the Liver King Brian Johnson.
I think Siim Land is probably better than Bryan Johnson or David Sinclair. However, there are people who are better on their science.
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Self-experimentation… well we know Charles here is a spring chiken, but ordinary mortals, such as 67 year old me, find zero relevance to my life from self reports of a 20’s or early 30’s guy like this Land fellow. Talk to me when you’re at least 60 when it comes to personal experiment reports. Of course, YMMV.
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I am almost 66, but I still think information from people in their 20s or 30s is worth analysing even if in the end it is useless.
I have been taking ashwagandha on and off over the years. I begin when a guru promotes it and stop when I observe no measurable or subjective benefits. It is most often touted as an adaptogen, which I believe is a BS term used when something actually has no benefit but claims to enhance the benefits of other supplements, etc.
It is only recently that I learned of the difference between ashwagandha and ashwagandha KSM-66:
"KSM-66 vs “plain” ashwagandha extracts (what actually differs)
KSM-66 is one specific branded extract with a reproducible spec:
- Plant part: root-only
- Standardization: ~5% withanolides (HPLC)
- Extraction: water-based, “full-spectrum” style process (manufacturer-described)
Why that matters: the same material is used across multiple human RCTs, so the evidence is easier to interpret."
Some possible benefits: (ChatGPT 5.2)
Best-supported (most “proven”) benefits specifically for KSM-66
1) Stress/anxiety reduction + lower cortisol (strongest, most replicated use-case)
A key RCT in stressed adults using KSM-66 300 mg twice daily (600 mg/day) for 60 days found significant reductions in multiple stress scales and serum cortisol vs placebo, with mostly mild side effects. PMC+2PubMed+2
2) Strength/training outcomes (good RCT signal, narrower population)
In resistance-trained males, KSM-66 300 mg twice daily for 8 weeks improved bench press and leg extension strength, increased muscle size, improved recovery (creatine kinase), and increased testosterone vs placebo. PMC+1
3) Sleep (evidence exists, but not uniquely “KSM-66-only”)
Sleep improvements are seen across several formulations in trials and meta-analyses (KSM-66, Sensoril, Shoden, etc.), so this is a broader “ashwagandha” effect rather than exclusive to KSM-66. PLOS+2ScienceDirect+2
It is also an anti-inflammatory to some degree and is shown to lower CRP values in some studies.
John, I believe you reported very low CRP values, so ashwagandha probably wouldn’t be of interest to you.
I am currently taking 600 mg of organic ashwagandha KSM 66 in the evening. If I don’t have any measurable improvements after taking it for 90 days, I will again stop taking ashwagandha.
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After seeing the sleep connection, in the last week-ish, I’ve added Sensolil ash to my nighttime stack (mel, mag, thea, traz) and NO doxylamine. So far seems like an improvement, but of course not nearly long enough to conclude anything definitive. Only 125mg of ash so far, but I’m going to 2X it starting tonight.