# \#sleep **URL:** https://www.rapamycin.news/tag/sleep/121.md [Latest](https://www.rapamycin.news/latest.md) · [Categories](https://www.rapamycin.news/categories.md) · [Tags](https://www.rapamycin.news/tags.md) --- ## [Is Dayvigo（lemborexant) a safe sleep pill?](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548)
**Author:** [@Rika\_Qu](https://www.rapamycin.news/u/Rika_Qu)\ **Replies:** 65\ **Last updated:** [November 6, 2026, 9:44pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548 "2026-11-06T21:44:52Z")
Dayvigo® (lemborexant), Eisai’s dual orexin receptor antagonist, was approved in China in recently. I am wondering if it’s the safest drug we can get on the market? In the past I tried several other sleep drugs and they don’t work very well on me. I tried a ‘safe’ pill Ramelteon and it halves my deep sleep duration according to the OURA ring. I also tried low dose of trazodone and it made me dr… --- ## [Imaging/reducing Enlarged perivascular spaces (EPVSs) on MRIs? #CSFFluid #GlymphaticClearance](https://www.rapamycin.news/t/imaging-reducing-enlarged-perivascular-spaces-epvss-on-mris-csffluid-glymphaticclearance/22415)
**Author:** [@AlexKChen](https://www.rapamycin.news/u/AlexKChen)\ **Replies:** 15\ **Last updated:** [July 9, 2026, 6:50pm UTC](https://www.rapamycin.news/t/imaging-reducing-enlarged-perivascular-spaces-epvss-on-mris-csffluid-glymphaticclearance/22415 "2026-07-09T18:50:04Z")
\[they have an entire tab to themselves on christin gloriso’s latest substack\] tFUS might be a route in the future But this is going to be a topic of continued study… MRI-visible dilated perivascular spaces (dPVS) BGdPVS (basal ganglia) and WMdPVS (white matter) MRI-visible dilated perivascular spaces in healthy young adults: A twin heritability study - PubMed. cilostazol #BrainHe… --- ## [GABA and improving sleep quality](https://www.rapamycin.news/t/gaba-and-improving-sleep-quality/20742)
**Author:** [@julianj1](https://www.rapamycin.news/u/julianj1)\ **Replies:** 24\ **Last updated:** [April 10, 2026, 7:25am UTC](https://www.rapamycin.news/t/gaba-and-improving-sleep-quality/20742 "2026-04-10T07:25:21Z")
I am very interested in sleep quality. At one time in my life I had sleep apnea. When I finally got a good night’s sleep with a CPAP machine I was totally amazed at the difference it made. That was a long time ago but the lesson was learnt and I very much try to have good sleep quality. However I am a bit of a worrier and that can keep me awake. I’ve experimented with a lot of different appro… --- ## [The interaction between DORA and RAPA](https://www.rapamycin.news/t/the-interaction-between-dora-and-rapa/22619)
**Author:** [@Rika\_Qu](https://www.rapamycin.news/u/Rika_Qu)\ **Replies:** 3\ **Last updated:** [January 9, 2026, 6:29am UTC](https://www.rapamycin.news/t/the-interaction-between-dora-and-rapa/22619 "2026-01-09T06:29:16Z")
I tried lemborexant and find it amazing! In my N=1 experiement, micro-dosing 1mg lemborexant increased my deep sleep according to OURA ring. However I read both lemborexant and rapamycin are motabolized by CYP3A4 enzymes. I’m concerned about potential drug-drug interactions. Is it safe to take rapamycin in the morning and lemborexant at night? --- ## [Sleep, Neurotransmitter and Longevity](https://www.rapamycin.news/t/sleep-neurotransmitter-and-longevity/21117)
**Author:** [@RTHR](https://www.rapamycin.news/u/RTHR)\ **Replies:** 1\ **Last updated:** [August 20, 2025, 5:08pm UTC](https://www.rapamycin.news/t/sleep-neurotransmitter-and-longevity/21117 "2025-08-20T17:08:45Z")
Hi everyone, I’ve been suffered for insomnia for 4 years. Literally I tried all the drugs, therapies and supplements for sleeping improvement. Here I want to record some of my medication history and my own sleeping supplement, since sleeping is one of the three pillars of longevity. Correct me if I make any mistake. Many hormones and neurotransmitters regulate sleep. GABA GABA is the primar…