# \#rapamycin **URL:** https://www.rapamycin.news/tag/rapamycin/1.md [Latest](https://www.rapamycin.news/latest.md) · [Categories](https://www.rapamycin.news/categories.md) · [Tags](https://www.rapamycin.news/tags.md) --- ## [BPH Prostate improvement?](https://www.rapamycin.news/t/bph-prostate-improvement/11640)
**Author:** [@sudiki](https://www.rapamycin.news/u/sudiki)\ **Replies:** 40\ **Last updated:** [November 8, 2026, 12:48am UTC](https://www.rapamycin.news/t/bph-prostate-improvement/11640 "2026-11-08T00:48:25Z")
new to site but I didn’t come across any posts so far on improved prostate health (BPH). Any input/comments? thx --- ## [Predicting and Preventing Alzheimers & Dementia (and minimizing risk)](https://www.rapamycin.news/t/predicting-and-preventing-alzheimers-dementia-and-minimizing-risk/13060)
**Author:** [@Deborah\_Hall](https://www.rapamycin.news/u/Deborah_Hall)\ **Replies:** 1108\ **Last updated:** [November 3, 2026, 11:41pm UTC](https://www.rapamycin.news/t/predicting-and-preventing-alzheimers-dementia-and-minimizing-risk/13060 "2026-11-03T23:41:08Z")
Alzheimers is #1 in my priority of worries. At present, age 74, I have no issues or warning signs. But my mother, aunt and grandmother, all very long lived, have/had it. I am well and fit, but A1C has been 5.7-5.8 for many years with no progression. Taking Metformin. I just ordered some Rapamycin. Aware that if take it before there are amyloid placques, Rapa can be protective. But if taken… --- ## [My Rapamycin Experience — A Personal Longevity Experiment](https://www.rapamycin.news/t/my-rapamycin-experience-a-personal-longevity-experiment/27056)
**Author:** [@Yilmaz\_Kaya](https://www.rapamycin.news/u/Yilmaz_Kaya)\ **Replies:** 7\ **Last updated:** [October 19, 2026, 3:46am UTC](https://www.rapamycin.news/t/my-rapamycin-experience-a-personal-longevity-experiment/27056 "2026-10-19T03:46:48Z")
My Rapamycin Experience — A Personal Longevity Experiment I decided to start taking rapamycin for longevity and thought it would be useful to document the experience here. This is not a recommendation. I am simply documenting what happens to me, including the things that don't happen. I was particularly influenced by Krister Kauppi's rapamycin journey and notes. His ongoing log gave me the idea … --- ## [Rapamycin and Impact on heart rate and HRV?](https://www.rapamycin.news/t/rapamycin-and-impact-on-heart-rate-and-hrv/3403)
**Author:** [@Texasgirl](https://www.rapamycin.news/u/Texasgirl)\ **Replies:** 172\ **Last updated:** [October 10, 2026, 10:52pm UTC](https://www.rapamycin.news/t/rapamycin-and-impact-on-heart-rate-and-hrv/3403 "2026-10-10T22:52:23Z")
Has anyone tracked their minimum heart rate and HRV overnight when taking Rapamycin? I notice that a couple of days after taking it my HR goes up and my HRV goes down. If I take a small dose, it returns to normal faster than if I take a larger dose. I have been watching my HR and HRV to decide when to take the next dose. Just wonder if anyone else is using their sleep tracker with overnight… --- ## [Oddway International Requiring a Prescription](https://www.rapamycin.news/t/oddway-international-requiring-a-prescription/26890)
**Author:** [@Tz11\_11](https://www.rapamycin.news/u/Tz11_11)\ **Replies:** 1\ **Last updated:** [October 2, 2026, 1:01pm UTC](https://www.rapamycin.news/t/oddway-international-requiring-a-prescription/26890 "2026-10-02T13:01:15Z")
Oddway is now including the following message in their responses to orders: “However, to process your order for the USA, a valid prescription is required for USA shipments by the U.S. Customs and Border Protection (CBP) as per their new regulations and must be included inside the parcel. Therefore, we request you to kindly provide a valid prescription so that we can process your order” Is anyon… --- ## [Rapamycin requires enteric coating, but has a score line?](https://www.rapamycin.news/t/rapamycin-requires-enteric-coating-but-has-a-score-line/25764)
**Author:** [@Stefan](https://www.rapamycin.news/u/Stefan)\ **Replies:** 37\ **Last updated:** [September 3, 2026, 2:19pm UTC](https://www.rapamycin.news/t/rapamycin-requires-enteric-coating-but-has-a-score-line/25764 "2026-09-03T14:19:29Z")
Hi… Matt Kaeberlein regularly mentions that it is important that rapamycin has enteric coating. For example in his latest video (Youtube ID 0AdYtOvdVk8, time index 1:20:42). I switched brands recently, and my new sirolimus tablets (“SiroBoon”) to my surprise have a clear score line, suggesting it is permissible to split them up to fine-tune dosing. But doesn’t that mean that these pills have no en… --- ## [Targeting immune senescence and systemic aging](https://www.rapamycin.news/t/targeting-immune-senescence-and-systemic-aging/5717)
**Author:** [@Caveatmtor](https://www.rapamycin.news/u/Caveatmtor)\ **Replies:** 8\ **Last updated:** [August 15, 2026, 12:31am UTC](https://www.rapamycin.news/t/targeting-immune-senescence-and-systemic-aging/5717 "2026-08-15T00:31:08Z")
Targeting cellular senescence to extend healthspan | Prof Paul Robbins An aged immune system drives senescence and ageing of solid organs Abstract Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly1,2. To define the contribution of immune system ageing to organism ageing, here we selectively deleted Ercc1, which encodes a cr… --- ## [Easiest way to buy online](https://www.rapamycin.news/t/easiest-way-to-buy-online/9929)
**Author:** [@Ktrain84](https://www.rapamycin.news/u/Ktrain84)\ **Replies:** 5\ **Last updated:** [July 23, 2026, 11:35pm UTC](https://www.rapamycin.news/t/easiest-way-to-buy-online/9929 "2026-07-23T23:35:32Z")
I’m having a hard time buying online. What are the best ways to buy Rapamycin online from a reliable source. I’m not to fond of using the “wise” app to send money. How is everyone else buying it? --- ## [The Latest Frontier in the World of Longevity: Organ Age](https://www.rapamycin.news/t/the-latest-frontier-in-the-world-of-longevity-organ-age/12626)
**Author:** [@Neo](https://www.rapamycin.news/u/Neo)\ **Replies:** 1\ **Last updated:** [March 10, 2024, 8:02pm UTC](https://www.rapamycin.news/t/the-latest-frontier-in-the-world-of-longevity-organ-age/12626 "2024-03-10T20:02:49Z")
Measuring organ age could be used to ward off future diseases www.wsj.com/health/wellness/aging-biological-age-organs-health-9b6a4798 Tony Wyss-Coray: The Science of Aging Organ-specific clocks, young plasma, getting rid of old cells, and the GLP-1 drugs --- ## [Does Rapamycin inhibit MTORC2 thus inhibit muscle growth?](https://www.rapamycin.news/t/does-rapamycin-inhibit-mtorc2-thus-inhibit-muscle-growth/25454)
**Author:** [@Dripman](https://www.rapamycin.news/u/Dripman)\ **Replies:** 2\ **Last updated:** [June 27, 2026, 6:42pm UTC](https://www.rapamycin.news/t/does-rapamycin-inhibit-mtorc2-thus-inhibit-muscle-growth/25454 "2026-06-27T18:42:54Z")
Sarcopenia occurs in the elderly but can be combatted with proper exercise. Does rapamycin/sirolimus inhibit muscle growth by inhibiting MTORC2 which increases muscle growth? --- ## [Effect of Nicotinamide in Skin Cancer and Actinic Keratoses](https://www.rapamycin.news/t/effect-of-nicotinamide-in-skin-cancer-and-actinic-keratoses/25370)
**Author:** [@RobTuck](https://www.rapamycin.news/u/RobTuck)\ **Replies:** 1\ **Last updated:** [June 21, 2026, 7:31pm UTC](https://www.rapamycin.news/t/effect-of-nicotinamide-in-skin-cancer-and-actinic-keratoses/25370 "2026-06-21T19:31:26Z")
Possibly relevant to rapamycin sun exposure and timing. “We screened 4730 citations and found 29 trials (3039 patients) meeting inclusion criteria. Nicotinamide was associated with a significant reduction in skin cancers compared to control (rate ratio 0.50 (95% CI, 0.29-0.85; I 2 = 64%; 552 patients; 5 trials); moderate strength of the evidence). Heterogeneity was explained by risk of bias. Nicot… --- ## [Sirolimus now available at TrumpRx dot gov ($0.66/mg)](https://www.rapamycin.news/t/sirolimus-now-available-at-trumprx-dot-gov-0-66-mg/25105)
**Author:** [@KevMoDee](https://www.rapamycin.news/u/KevMoDee)\ **Replies:** 32\ **Last updated:** [June 18, 2026, 9:57am UTC](https://www.rapamycin.news/t/sirolimus-now-available-at-trumprx-dot-gov-0-66-mg/25105 "2026-06-18T09:57:05Z")
90 1 mg tabs for $68 in my area. Hope this helps everyone who is taking it. Website: https://trumprx.gov --- ## [Dr. Reddy's Sirolimus Factory Report](https://www.rapamycin.news/t/dr-reddys-sirolimus-factory-report/23885)
**Author:** [@SadieNC](https://www.rapamycin.news/u/SadieNC)\ **Replies:** 8\ **Last updated:** [June 18, 2026, 12:24am UTC](https://www.rapamycin.news/t/dr-reddys-sirolimus-factory-report/23885 "2026-06-18T00:24:04Z")
Propublica has a new search tool to determine any manufacturer issues that are not made public by FDA. Heads up: Here is the link to the manufacturer of Dr. Reddy’s sirolimus 1mg, in case anyone uses that product. Interpret as you wish. --- ## [Can Rapamycin Reverse Alzheimer's? What the Data Actually Shows (Kaeberlein)](https://www.rapamycin.news/t/can-rapamycin-reverse-alzheimers-what-the-data-actually-shows-kaeberlein/25324)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 0\ **Last updated:** [June 17, 2026, 5:17am UTC](https://www.rapamycin.news/t/can-rapamycin-reverse-alzheimers-what-the-data-actually-shows-kaeberlein/25324 "2026-06-17T05:17:03Z")
In this episode of Longevity Science, I sit down with Dr. Veronica Galvan, Director of the Nathan Shock Center at the University of Oklahoma and Editor-in-Chief of Geroscience, to explore more than a decade of groundbreaking research on mTOR, rapamycin, brain aging, and Alzheimer’s disease. Dr. Galvan was among the first researchers to demonstrate that inhibiting mTOR with rapamycin can restore … --- ## [My DOG, My PARTNER, and ME: A Week by Week Rapalogue](https://www.rapamycin.news/t/my-dog-my-partner-and-me-a-week-by-week-rapalogue/4252)
**Author:** [@HigoMe33](https://www.rapamycin.news/u/HigoMe33)\ **Replies:** 110\ **Last updated:** [June 16, 2026, 5:34am UTC](https://www.rapamycin.news/t/my-dog-my-partner-and-me-a-week-by-week-rapalogue/4252 "2026-06-16T05:34:56Z")
The journey begins! I’ll use this thread to report my experience as my partner, my dog, and I begin taking Rapamycin (sirolimus). BIO-INFO I am 47 and weigh 180lbs. Using pre-rapa tests, my Aging.ai age was 49 and my Levine age was 43. I’m healthy and athletic. I lift weights twice a week for around 90 minutes each time, getting my heart rate up to 183 max between 5-10 times during the workout.… --- ## [A Roadmap to FDA Approval for Longevity Drugs](https://www.rapamycin.news/t/a-roadmap-to-fda-approval-for-longevity-drugs/25278)
**Author:** [@mattbagg](https://www.rapamycin.news/u/mattbagg)\ **Replies:** 0\ **Last updated:** [June 13, 2026, 8:07pm UTC](https://www.rapamycin.news/t/a-roadmap-to-fda-approval-for-longevity-drugs/25278 "2026-06-13T20:07:42Z")
On May 27, 2026, the Reagan-Udall Foundation for the FDA, working alongside ARPA-H and the XPRIZE Foundation, ran a full-day public meeting on gerotherapeutic drug and biologic development. Strip away the dense regulatory jargon, and it was the exact conversation the longevity industry has needed for years: a direct discussion between developers and regulators on how to translate geroscience into … --- ## [Peptides + rapa + acarbose](https://www.rapamycin.news/t/peptides-rapa-acarbose/24903)
**Author:** [@Ben\_S](https://www.rapamycin.news/u/Ben_S)\ **Replies:** 4\ **Last updated:** [May 29, 2026, 1:54pm UTC](https://www.rapamycin.news/t/peptides-rapa-acarbose/24903 "2026-05-29T13:54:55Z")
I’ve been taking rapa for around 3 years now / paired with metformin and the past year or two acarbose. I’m would like to try some peptides and am curious what is the general consensus around it. --- ## [Rapamycin as a possible treatment for Long Covid](https://www.rapamycin.news/t/rapamycin-as-a-possible-treatment-for-long-covid/9156)
**Author:** [@Charles\_Wallace](https://www.rapamycin.news/u/Charles_Wallace)\ **Replies:** 21\ **Last updated:** [May 28, 2026, 6:17pm UTC](https://www.rapamycin.news/t/rapamycin-as-a-possible-treatment-for-long-covid/9156 "2026-05-28T18:17:54Z")
This article by Dr Eric Topol presents a recent finding on possible mechanisms behind the Long Covid disaster, and surprise, here is rapamycin being put forward as a possible treatment! The new finding is that mitochondrial damage was found, and that does make sense as a way to explain many long covid symptoms. A recent post (9/1/23) here by RapAdmin mentions that the process of recycling/repl… --- ## [Using limited supplies](https://www.rapamycin.news/t/using-limited-supplies/24927)
**Author:** [@Gerald\_Taylor](https://www.rapamycin.news/u/Gerald_Taylor)\ **Replies:** 2\ **Last updated:** [May 25, 2026, 5:38pm UTC](https://www.rapamycin.news/t/using-limited-supplies/24927 "2026-05-25T17:38:35Z")
Hi, I managed to get a prescription for 200 mg rapmune whilst on holiday in Turkey. I was intending to make some into a topical cream, for treating a large facial birthmark, alongside laser - which it can do, but I calculate that It’ll only make 10 ml of 2% cream. Is 200 mg enough to get anti aging benefits if I just take it orally? That’s super interesting too, and I believe ingesting rapa can… --- ## [Alan Green has updated his website](https://www.rapamycin.news/t/alan-green-has-updated-his-website/7523)
**Author:** [@RPS](https://www.rapamycin.news/u/RPS)\ **Replies:** 2\ **Last updated:** [May 11, 2026, 6:52pm UTC](https://www.rapamycin.news/t/alan-green-has-updated-his-website/7523 "2026-05-11T18:52:08Z")
May 2023 Update: 1250 patients on Rapamycin. 1. Evaluation of off‑label rapamycin use to promote healthspan in 333 adults, Kaeberline, Alan Green https://rdcu.be/dcirv This paper is the most important paper in the clinical treatment of Aging. Rapamycin is the most important anti-aging drug. There is a huge amount of speculation; but prior to this paper, no data. The proof of the pudding is i… --- ## [Peter Attia MD - Disappointing results from the first rapamycin-plus-exercise trial](https://www.rapamycin.news/t/peter-attia-md-disappointing-results-from-the-first-rapamycin-plus-exercise-trial/24610)
**Author:** [@JazzMann](https://www.rapamycin.news/u/JazzMann)\ **Replies:** 1\ **Last updated:** [May 3, 2026, 12:21pm UTC](https://www.rapamycin.news/t/peter-attia-md-disappointing-results-from-the-first-rapamycin-plus-exercise-trial/24610 "2026-05-03T12:21:43Z")
Disappointing results from the first rapamycin-plus-exercise trial --- ## [Rapamycin and psoriasis](https://www.rapamycin.news/t/rapamycin-and-psoriasis/16627)
**Author:** [@youngman1](https://www.rapamycin.news/u/youngman1)\ **Replies:** 5\ **Last updated:** [April 27, 2026, 1:55pm UTC](https://www.rapamycin.news/t/rapamycin-and-psoriasis/16627 "2026-04-27T13:55:56Z")
Does Rapamycin have any effect on psoriasis? --- ## [Purchasing Rapamycin](https://www.rapamycin.news/t/purchasing-rapamycin/23366)
**Author:** [@sharonmcknight](https://www.rapamycin.news/u/sharonmcknight)\ **Replies:** 43\ **Last updated:** [April 17, 2026, 9:34pm UTC](https://www.rapamycin.news/t/purchasing-rapamycin/23366 "2026-04-17T21:34:46Z")
This is like pulling teeth. Going on 2 months, unable to purchase rapamycin for personal use. This is ridiculous. When I do get an email offer, I look up the name of the company and it can’t be trusted! I even sent emails to a few sellers suggested to me here, no luck. Can anyone tell me who I can buy from?? Thank you! --- ## [I fed my longevity stack proteins to BioReason-Pro — here's what the AI biologist found](https://www.rapamycin.news/t/i-fed-my-longevity-stack-proteins-to-bioreason-pro-heres-what-the-ai-biologist-found/24048)
**Author:** [@wonder](https://www.rapamycin.news/u/wonder)\ **Replies:** 4\ **Last updated:** [March 29, 2026, 12:36pm UTC](https://www.rapamycin.news/t/i-fed-my-longevity-stack-proteins-to-bioreason-pro-heres-what-the-ai-biologist-found/24048 "2026-03-29T12:36:17Z")
I fed my longevity stack proteins to BioReason-Pro — here’s what the AI biologist found Arc Institute just released BioReason-Pro — the first multimodal reasoning model for protein function prediction. It doesn’t just label proteins; it reasons through them step by step, like a biologist colleague explaining their logic. Human experts preferred its annotations over curated UniProt entries 79% of t… --- ## [Ultra Low Dose Rapa Benefits](https://www.rapamycin.news/t/ultra-low-dose-rapa-benefits/24027)
**Author:** [@Thumder3581](https://www.rapamycin.news/u/Thumder3581)\ **Replies:** 7\ **Last updated:** [March 27, 2026, 2:16pm UTC](https://www.rapamycin.news/t/ultra-low-dose-rapa-benefits/24027 "2026-03-27T14:16:05Z")
I have been on rapa since 2021. I started with the standard build up on my way to 6mg. However, a funny thing happened on the way to the farm. I was taking things really slow and had built up to 3mg weekly. For some reason I decided to stop there for the time being. After anohter month I began to notice several unexpected things. 1. My allergies (a lifelong batle) had almost totally disappeared. I… --- ## [Push Health prescribing experience](https://www.rapamycin.news/t/push-health-prescribing-experience/3802)
**Author:** [@Elizabeth\_Kirby](https://www.rapamycin.news/u/Elizabeth_Kirby)\ **Replies:** 86\ **Last updated:** [March 19, 2026, 12:24pm UTC](https://www.rapamycin.news/t/push-health-prescribing-experience/3802 "2026-03-19T12:24:09Z")
In case people are interested … People have mentioned push health on the site. Today I went to the site & signed up & as it turned out, have a prescription & some rapa that will soon be on the way to me. In more detail, I chose the prescription refill option for the sign up & put in that I wanted rapamycin, aka sirolimus. In not a long time, I got a message that I had been matched with a provi… --- ## [Boxes of 1mg and 2mg Pfizer Rapamune available for sale in UK](https://www.rapamycin.news/t/boxes-of-1mg-and-2mg-pfizer-rapamune-available-for-sale-in-uk/23969)
**Author:** [@Loster](https://www.rapamycin.news/u/Loster)\ **Replies:** 3\ **Last updated:** [March 18, 2026, 6:01pm UTC](https://www.rapamycin.news/t/boxes-of-1mg-and-2mg-pfizer-rapamune-available-for-sale-in-uk/23969 "2026-03-18T18:01:22Z")
Hi all, I have 13 boxes of 1mg and 16 boxes of the 2mg Pfizer Rapamune available for sale. They are all 30 tablet boxes. They have expired - with expired dates in 2022 and 2023. But the boxes are unopened and the blister packs untouched. I’ve personally been fine taking them past the date on the box - but obviously that may not be OK for some. They were used for their immunosuppression effec… --- ## [Rapamycin & Ketamine](https://www.rapamycin.news/t/rapamycin-ketamine/5234)
**Author:** [@Jerry\_Cahill](https://www.rapamycin.news/u/Jerry_Cahill)\ **Replies:** 21\ **Last updated:** [March 17, 2026, 5:25am UTC](https://www.rapamycin.news/t/rapamycin-ketamine/5234 "2026-03-17T05:25:38Z")
In December I read a study that demonstrated that Rapamycin when taken with Ketamine, extends the benefits of Ketamine. Does anyone know more about this or have personal experience? I have just located a new source for Rapamycin and will be doing another round of Oral Ketamine. I found Ketamine to be very interesting and on 4 occasions I was in a much better place mentally. But they did not la… --- ## [Evaluation of rapamycin as a neuroprotective treatment in Alzheimer’s disease (ERAP): a 6-month trial](https://www.rapamycin.news/t/evaluation-of-rapamycin-as-a-neuroprotective-treatment-in-alzheimer-s-disease-erap-a-6-month-trial/22712)
**Author:** [@WJ\_PhD](https://www.rapamycin.news/u/WJ_PhD)\ **Replies:** 7\ **Last updated:** [March 16, 2026, 8:37am UTC](https://www.rapamycin.news/t/evaluation-of-rapamycin-as-a-neuroprotective-treatment-in-alzheimer-s-disease-erap-a-6-month-trial/22712 "2026-03-16T08:37:39Z")
Pre-print publication so preliminary. 7 mg weekly dose for 26 weeks. Several CSF biomarkers increased (including total tau) indicative of possible neuron injury. Some Increases in brain glucose metabolism seen which is positive. Overall, kind of a mixed bag IMHO. --- ## [Glycine+NAC vs Rapamycin](https://www.rapamycin.news/t/glycine-nac-vs-rapamycin/1500)
**Author:** [@Goran](https://www.rapamycin.news/u/Goran)\ **Replies:** 377\ **Last updated:** [March 14, 2026, 12:56pm UTC](https://www.rapamycin.news/t/glycine-nac-vs-rapamycin/1500 "2026-03-14T12:56:47Z")
ITP study showed a 6% life extension in mice by Glycine, another study showed a 20% life extension in mice my Glycine + NAC (N-Acetyl Cysteine), That is close to Rapamycin territory. Rapamycin inhibits MTOR, and thats the theory on the reasons of longevity. Amino acids activate MTOR and Glycine and NAC are amino acids, so should in theory not be longevity candidates. I am using Glycine 8mg a… [Next page](https://www.rapamycin.news/tag/rapamycin/1.md?match_all_tags=true&page=1&tags%5B%5D=rapamycin)