# \#metformin **URL:** https://www.rapamycin.news/tag/metformin/2.md [Latest](https://www.rapamycin.news/latest.md) · [Categories](https://www.rapamycin.news/categories.md) · [Tags](https://www.rapamycin.news/tags.md) --- ## [I fed my longevity stack proteins to BioReason-Pro — here's what the AI biologist found](https://www.rapamycin.news/t/i-fed-my-longevity-stack-proteins-to-bioreason-pro-heres-what-the-ai-biologist-found/24048)
**Author:** [@wonder](https://www.rapamycin.news/u/wonder)\ **Replies:** 4\ **Last updated:** [March 29, 2026, 12:36pm UTC](https://www.rapamycin.news/t/i-fed-my-longevity-stack-proteins-to-bioreason-pro-heres-what-the-ai-biologist-found/24048 "2026-03-29T12:36:17Z")
I fed my longevity stack proteins to BioReason-Pro — here’s what the AI biologist found Arc Institute just released BioReason-Pro — the first multimodal reasoning model for protein function prediction. It doesn’t just label proteins; it reasons through them step by step, like a biologist colleague explaining their logic. Human experts preferred its annotations over curated UniProt entries 79% of t… --- ## [I Reviewed 15 Studies on Metformin and Asthma — Here’s What I Found](https://www.rapamycin.news/t/i-reviewed-15-studies-on-metformin-and-asthma-here-s-what-i-found/19737)
**Author:** [@AustraliaLongevity](https://www.rapamycin.news/u/AustraliaLongevity)\ **Replies:** 3\ **Last updated:** [February 5, 2026, 5:06am UTC](https://www.rapamycin.news/t/i-reviewed-15-studies-on-metformin-and-asthma-here-s-what-i-found/19737 "2026-02-05T05:06:30Z")
I reviewed a wide range of studies on metformin and its impact on asthma. The overall consensus is strongly positive, especially in people with asthma who also have diabetes, obesity, or metabolic dysfunction. Most studies show reduced asthma exacerbations (fewer ER visits and hospitalizations) in people taking metformin. Benefits are likely due to anti-inflammatory effects via AMPK activation,… --- ## [Inquiry Regarding Rapa, Metformin, Acarbose, and Their Alignment with My Conditions](https://www.rapamycin.news/t/inquiry-regarding-rapa-metformin-acarbose-and-their-alignment-with-my-conditions/18467)
**Author:** [@emanuele](https://www.rapamycin.news/u/emanuele)\ **Replies:** 28\ **Last updated:** [February 14, 2025, 3:25pm UTC](https://www.rapamycin.news/t/inquiry-regarding-rapa-metformin-acarbose-and-their-alignment-with-my-conditions/18467 "2025-02-14T15:25:54Z")
Hello, I’ve been following this community for a while, and I’m grateful for everything I’ve learned here! I’m a 42-year-old male with HBP, which is under control with ARB medication. I also have MTHFR, COMT, and the APOE 4 mutation (one allele, still unsure about the other). Additionally, I’ve been dealing with inverse psoriasis for a few years, which remains somewhat persistent despite my effort… --- ## [Rapamycin + Metformin + Rosuvastatin + Dihydromyricetin stack](https://www.rapamycin.news/t/rapamycin-metformin-rosuvastatin-dihydromyricetin-stack/17553)
**Author:** [@snax444](https://www.rapamycin.news/u/snax444)\ **Replies:** 10\ **Last updated:** [December 5, 2024, 1:12am UTC](https://www.rapamycin.news/t/rapamycin-metformin-rosuvastatin-dihydromyricetin-stack/17553 "2024-12-05T01:12:16Z")
As several others on this forum, I’m aiming to take advantage of potential benefits of rapamycin, while minimizing the potential impacts on glucose and lipid parameters. Please share your thoughts on my current conservative protocol below (which is aimed at general health and longevity) Once-weekly Rapamycin (Sirolimus 5mg) Once-weekly Rosuvastatin 5mg + Bempedoic Acid 180mg + Ezetimibe 10mg Tw… --- ## [Metformin decelerates aging clock in male monkeys](https://www.rapamycin.news/t/metformin-decelerates-aging-clock-in-male-monkeys/16191)
**Author:** [@Jjazz](https://www.rapamycin.news/u/Jjazz)\ **Replies:** 43\ **Last updated:** [November 28, 2024, 10:34pm UTC](https://www.rapamycin.news/t/metformin-decelerates-aging-clock-in-male-monkeys/16191 "2024-11-28T22:34:25Z")
Metformin decelerates aging clock in male monkeys https://www.cell.com/cell/abstract/S0092-8674(24)00914-0 Highlights • Metformin prevents brain atrophy, elevating cognitive function in aged male primates • Metformin slows the pace of aging across diverse male primate tissues • Metformin counterparts neuronal aging, delivering geroprotection via Nrf2 in male primates Summary In a rigorous 4… --- ## [Late life Metformin shortens lifespan?](https://www.rapamycin.news/t/late-life-metformin-shortens-lifespan/7361)
**Author:** [@LaraPo](https://www.rapamycin.news/u/LaraPo)\ **Replies:** 87\ **Last updated:** [June 9, 2024, 9:32pm UTC](https://www.rapamycin.news/t/late-life-metformin-shortens-lifespan/7361 "2024-06-09T21:32:01Z")
--- ## [Metformin More Popular than Acarbose?](https://www.rapamycin.news/t/metformin-more-popular-than-acarbose/7020)
**Author:** [@EasterEggBiff](https://www.rapamycin.news/u/EasterEggBiff)\ **Replies:** 25\ **Last updated:** [May 4, 2024, 12:25am UTC](https://www.rapamycin.news/t/metformin-more-popular-than-acarbose/7020 "2024-05-04T00:25:30Z")
Ok so Youtube and Google results are by no means evidence of efficacy of course, but it seems to me that there are more articles and popular discussion around Metformin re longevity boosting potential, than Acarbose. This is DESPITE the evidence that metformin increases lifespan being quite controversial/in some studies not supported (ITP trial), whereas I have not seen same uncertainty around aca… --- ## [Towards natural mimetics of metformin and rapamycin](https://www.rapamycin.news/t/towards-natural-mimetics-of-metformin-and-rapamycin/13715)
**Author:** [@Herm](https://www.rapamycin.news/u/Herm)\ **Replies:** 14\ **Last updated:** [May 2, 2024, 11:26pm UTC](https://www.rapamycin.news/t/towards-natural-mimetics-of-metformin-and-rapamycin/13715 "2024-05-02T23:26:17Z")
Abstract: Aging is now at the forefront of major challenges faced globally, creating an immediate need for safe, widescale interventions to reduce the burden of chronic disease and extend human healthspan. Metformin and rapamycin are two FDA‐approved mTOR inhibitors proposed for this purpose, exhibiting significant anti‐cancer and anti‐aging properties beyond their current clinical applications… --- ## [Is Metformin a Drug for All Diseases?](https://www.rapamycin.news/t/is-metformin-a-drug-for-all-diseases/12473)
**Author:** [@RobTuck](https://www.rapamycin.news/u/RobTuck)\ **Replies:** 8\ **Last updated:** [April 9, 2024, 6:54pm UTC](https://www.rapamycin.news/t/is-metformin-a-drug-for-all-diseases/12473 "2024-04-09T18:54:56Z")
Is Metformin a Drug for All Diseases.pdf (1.4 MB) --- ## [Buying Rapamycin in the Netherlands](https://www.rapamycin.news/t/buying-rapamycin-in-the-netherlands/11353)
**Author:** [@Ruben](https://www.rapamycin.news/u/Ruben)\ **Replies:** 5\ **Last updated:** [January 1, 2024, 1:03pm UTC](https://www.rapamycin.news/t/buying-rapamycin-in-the-netherlands/11353 "2024-01-01T13:03:24Z")
I’m following Blueprint. I’m from the Netherlands, Europe. So I need Metformin Acarbose Rapamycin Anybody here have experience buying and importing that they could share with me? --- ## [Take Rapamycin with 2,000 mg of Metformin daily? Help with Diabetic Hubs](https://www.rapamycin.news/t/take-rapamycin-with-2-000-mg-of-metformin-daily-help-with-diabetic-hubs/9683)
**Author:** [@abookwriter2](https://www.rapamycin.news/u/abookwriter2)\ **Replies:** 18\ **Last updated:** [October 3, 2023, 2:16am UTC](https://www.rapamycin.news/t/take-rapamycin-with-2-000-mg-of-metformin-daily-help-with-diabetic-hubs/9683 "2023-10-03T02:16:09Z")
I take rapamycin and am happy with its effects. My husband thinks he should take it too after listening to Ben Greenfield podcast. Should he if he’s not working at getting off metformin megadose and twice daily insulin? He’s not serious about changing diet radically, taking up exercise again after a four-year-extended COVID hiatus. Is it helpful at this point or harmful? He’s 63, maybe 25 pound… --- ## [Seeking advice, afraid I have to quit](https://www.rapamycin.news/t/seeking-advice-afraid-i-have-to-quit/1037)
**Author:** [@Danlalane](https://www.rapamycin.news/u/Danlalane)\ **Replies:** 64\ **Last updated:** [July 24, 2023, 4:27pm UTC](https://www.rapamycin.news/t/seeking-advice-afraid-i-have-to-quit/1037 "2023-07-24T16:27:29Z")
I posted a little of this in the ‘side effects 2’ thread but figured a headliner was the right place.emphasized text I started Rapamycin and Metformin roughly the same time. Friday night Metformin 250mg, up to 500mg nightly thereafter. Rapamycin 2Mg following Monday. I did weekly with Rapamycin 2nd dose 3mg with grapefruit juice and 3rd dose a half grapefruit before 3mg. I felt some extra energy.… --- ## [Trusty rapa / metformin / acarbose / LDN provider + feedback on my stack](https://www.rapamycin.news/t/trusty-rapa-metformin-acarbose-ldn-provider-feedback-on-my-stack/6909)
**Author:** [@medaura](https://www.rapamycin.news/u/medaura)\ **Replies:** 13\ **Last updated:** [June 28, 2023, 2:35am UTC](https://www.rapamycin.news/t/trusty-rapa-metformin-acarbose-ldn-provider-feedback-on-my-stack/6909 "2023-06-28T02:35:27Z")
Hi everyone, I’ve been lurking for a while but thought I’d share my Indian provider for my meds as a public service announcement—I’ve been getting the best price I’ve come across and consistently great service over multiple deliveries. Here is the website and product catalog (you search for the product you have in mind — e.g. acarbose): Wholesale Trader of Pharmaceutical Tablets & Ed Medicine by … --- ## [Taking Acarbose AND Metformin?](https://www.rapamycin.news/t/taking-acarbose-and-metformin/6527)
**Author:** [@EasterEggBiff](https://www.rapamycin.news/u/EasterEggBiff)\ **Replies:** 15\ **Last updated:** [April 16, 2023, 8:26pm UTC](https://www.rapamycin.news/t/taking-acarbose-and-metformin/6527 "2023-04-16T20:26:09Z")
Posted this by accident initially on my alt account that I created when I forgot my password for the main, so apologies for the repetition. So I am now revising my regime. As provided in other forum posts, 2mg of rapa a week seemingly caused oedema on a confined area of my left cheek based on a biopsy and Dr Green assessment. So it appears as if I am relatively responsive to low dose rapa. As I w…