# \#17-alpha-estradiol
**URL:** https://www.rapamycin.news/tag/17-alpha-estradiol/48.md
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## [17-Alpha Estradiol - Another Top Anti-Aging Drug](https://www.rapamycin.news/t/17-alpha-estradiol-another-top-anti-aging-drug/92)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\
**Replies:** 162\
**Last updated:** [May 9, 2026, 8:22pm UTC](https://www.rapamycin.news/t/17-alpha-estradiol-another-top-anti-aging-drug/92 "2026-05-09T20:22:48Z")
17 Alpha Estradiol is probably the second best-performing longevity drug after rapamycin. We wish it was a supplement, but you can only buy it as drug or chemical right now. We’ve identified sources and pricing / cost below but its hard to get. Apollo ventures has announced that it is seeking to develop 17 alpha estradiol as a human drug which is great, but it will likely greatly increase the c…
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## [17-alpha-Estradiol (Alfatradiol) Compounding Pharmacy?](https://www.rapamycin.news/t/17-alpha-estradiol-alfatradiol-compounding-pharmacy/23127)
**Author:** [@Hadley](https://www.rapamycin.news/u/Hadley)\
**Replies:** 3\
**Last updated:** [January 15, 2026, 5:29pm UTC](https://www.rapamycin.news/t/17-alpha-estradiol-alfatradiol-compounding-pharmacy/23127 "2026-01-15T17:29:39Z")
Can anyone tell me if they have found an online compounding pharmacy in the US that will compound a 17-alpha-Estradiol topical hydroethanolic cream? Active Ingredient: 17-alpha Estradiol (Alfatradiol) CAS# 57-91-0 Form: Transdermal Cream or Hydroalcoholic Topical Solution Strength: 0.05% to 0.1% Thank you for your time!
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## [Oral 17-alpha-Estradiol (17a-E2), 2026 update on dose, effects and sourcing + purity](https://www.rapamycin.news/t/oral-17-alpha-estradiol-17a-e2-2026-update-on-dose-effects-and-sourcing-purity/22961)
**Author:** [@Chris](https://www.rapamycin.news/u/Chris)\
**Replies:** 2\
**Last updated:** [January 6, 2026, 11:37am UTC](https://www.rapamycin.news/t/oral-17-alpha-estradiol-17a-e2-2026-update-on-dose-effects-and-sourcing-purity/22961 "2026-01-06T11:37:21Z")
Everybody with ORAL 17-Alpha-Estradiol experience, please share your updated information below on your daily dose, effects (feeling in nipples?) - and especially if you have test results from hormone levels before and after - and information on sourcing + purity for ORAL use. Please keep comments short, factual and scientific. To set the background information, below I have pasted in Gemini lat…
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## [17-alpha-Estradiol May Work Through the Estrogen Receptor After All](https://www.rapamycin.news/t/17-alpha-estradiol-may-work-through-the-estrogen-receptor-after-all/8039)
**Author:** [@RapamycinCurious](https://www.rapamycin.news/u/RapamycinCurious)\
**Replies:** 22\
**Last updated:** [July 19, 2025, 8:48am UTC](https://www.rapamycin.news/t/17-alpha-estradiol-may-work-through-the-estrogen-receptor-after-all/8039 "2025-07-19T08:48:12Z")
Quoting @RapAdmin 's summary of Peter Attia’s podcast with Richard Miller: Richard Miller tells Peter Attia that a pharmacologist named James Simpkins has studied estrogen receptors and suggested investigating 17α-Estradiol. He had tried to make a compound that was like estrogen—17β-estradiol—which is generically crudely referred to as estrogen. … James Simpkins synthesized 17α-Estradiol—very m…
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## [17-alpha-Estradiol Study in Marmosets](https://www.rapamycin.news/t/17-alpha-estradiol-study-in-marmosets/15455)
**Author:** [@RapamycinCurious](https://www.rapamycin.news/u/RapamycinCurious)\
**Replies:** 3\
**Last updated:** [August 8, 2024, 10:47am UTC](https://www.rapamycin.news/t/17-alpha-estradiol-study-in-marmosets/15455 "2024-08-08T10:47:48Z")
A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus) ORIGINAL ARTICLE Published: 06 August 2024 Roshini Sathiaseelan, Jose V. V. Isola, Roberto Santín-Márquez, Daniel Adekunbi, Michal Fornalik, Adam B. Salmon & Michael B. Stout 17α-estradiol extends healthspan and lifespan in male mice without significant feminization or deleterious effec…