# UPDATE—World’s First Drug to Regrow Teeth Enters Clinical Trials **URL:** \ **Category:** General\ **Created:** [September 30, 2023, 12:13am UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705 "2023-09-30T00:13:52Z")\ **Posts on this page:** 12\ **Page:** 1
**Author:** ![Joseph](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/j/dc4da7/32.png) [@Joseph](https://www.rapamycin.news/u/Joseph)\ **Post date:** [September 30, 2023, 12:13am UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/1 "2023-09-30T00:13:52Z")
Sep 29, 2023 > **[UPDATE—World’s First Drug to Regrow Teeth Enters Clinical Trials](https://www.goodnewsnetwork.org/update-worlds-first-drug-to-regrow-teeth-enters-clinical-trials/)** > > If successful, the next trial will include children with anodontia, a condition where children are born without some of their teeth.  ---
**Author:** ![KarlT](https://www.rapamycin.news/user_avatar/www.rapamycin.news/karlt/32/12733_2.png) [@KarlT](https://www.rapamycin.news/u/KarlT)\ **Post date:** [September 30, 2023, 1:33pm UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/2 "2023-09-30T13:33:26Z")
Anyone here a dentist or have a good understanding of this? What is a tooth bud? Are buds still present in adults?, if you’ve had tooth removed? ---
**Author:** ![JuanDaw](https://www.rapamycin.news/user_avatar/www.rapamycin.news/juandaw/32/5311_2.png) [@JuanDaw](https://www.rapamycin.news/u/JuanDaw)\ **Post date:** [September 30, 2023, 1:53pm UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/3 "2023-09-30T13:53:34Z")
Arhu is a dentist/MD. ---
**Author:** ![Phillipe](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/p/22d042/32.png) [@Phillipe](https://www.rapamycin.news/u/Phillipe)\ **Post date:** [September 30, 2023, 9:07pm UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/4 "2023-09-30T21:07:00Z")
No tooth buds in adults. Unlike hair follicles, it is not a permanent regenerative organ. ---
**Author:** ![DeStrider](https://www.rapamycin.news/user_avatar/www.rapamycin.news/destrider/32/19418_2.png) [@DeStrider](https://www.rapamycin.news/u/DeStrider)\ **Post date:** [June 13, 2024, 5:09am UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/5 "2024-06-13T05:09:07Z")
[![](https://www.rapamycin.news/uploads/default/original/3X/b/5/b587ce3cdf5591c93a48e2cb4fd38f6e452ac290.jpeg "Regrowing Teeth In Old Age Is Possible! Human Trial Starts This Year") ](https://www.youtube.com/watch?v=QZi8od-WMWE) ---
**Author:** ![J0hn](https://www.rapamycin.news/user_avatar/www.rapamycin.news/j0hn/32/34374_2.png) [@J0hn](https://www.rapamycin.news/u/J0hn)\ **Post date:** [June 13, 2024, 1:03pm UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/6 "2024-06-13T13:03:06Z")
….the inventor of the process believes that humans may have THREE sets of tooth buds. I’m hoping he’s right 😃 🦷 > Blockquote And that hope, Takahashi claims, should be further encouraged by the fact that we already come pre-loaded with the starting point. He has said that his previous research shows that humans have the start of a third set of teeth already embedded in our mouths. This is most visibly exhibited by the 1 percent of humans with hyperdontia, the growing of more than a full set of teeth. And Takahashi believes that activating that third set of buds with the right gene manipulation could promote teeth regrowth. > Blockquote > **[Humans Have a Third Set of Teeth. New Medicine May Help Them Grow.](https://www.popularmechanics.com/science/health/a44786433/humans-have-third-set-teeth/#)** > > They could be ready by 2030. > **[World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan -...](https://mainichi.jp/english/articles/20230609/p2a/00m/0sc/026000c)** > > OSAKA -- A Japanese research team is making progress on the development of a groundbreaking medication that may allow people to grow new teeth, with c ---
**Author:** ![Walter\_Brown](https://www.rapamycin.news/user_avatar/www.rapamycin.news/walter_brown/32/25586_2.png) [@Walter\_Brown](https://www.rapamycin.news/u/Walter_Brown)\ **Post date:** [June 13, 2024, 1:14pm UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/7 "2024-06-13T13:14:27Z")
This patent seems to be by the company: [JP2023028834A - Implant bodies and dental implants - Google Patents](https://patents.google.com/patent/JP2023028834A/) I spotted this in the text: > The third raw tooth is the next tooth to grow after the permanent tooth. In mammals, there is a third tooth ridge that is vestigial, although it has the potential to form new teeth under the permanent teeth. A third tooth can be generated from the third tooth embankment by locally administering a drug that promotes the growth of the third tooth ridge, for example, siRNA that inhibits the expression of the USAG-1 gene, in the vicinity of the third tooth ridge. The dental implant 100 is attached, for example, above the third tooth ridge in the alveolar bone 210 immediately after administering such an agent or after the third raw tooth is formed to some extent. ---
**Author:** ![Dr.Bart](https://www.rapamycin.news/user_avatar/www.rapamycin.news/dr.bart/32/13302_2.png) [@Dr.Bart](https://www.rapamycin.news/u/Dr.Bart)\ **Post date:** [June 13, 2024, 5:05pm UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/8 "2024-06-13T17:05:19Z")
I imagine having a dental implant already bored in to the bone would destroy that third tooth bud… 😢 ---
**Author:** ![DrT](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/d/7993a0/32.png) [@DrT](https://www.rapamycin.news/u/DrT)\ **Post date:** [June 14, 2024, 8:01am UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/9 "2024-06-14T08:01:50Z")
I seem to recall that there are several cases in the literature reporting adults having grown a 3rd set of teeth and (really stretching the memory here) a single case of a 4th set. But don’t quote me on that. ---
**Author:** ![Phillipe](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/p/22d042/32.png) [@Phillipe](https://www.rapamycin.news/u/Phillipe)\ **Post date:** [June 14, 2024, 4:15pm UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/10 "2024-06-14T16:15:24Z")
I’ve never seen evidence of a “third tooth ridge” or vestigial teeth other than the primary teeth which are, of course, normal human odontogenic development. Some have interpreted supernumerary teeth as a third set but that is not correct. There are other dental dysplasias that manifest multiple teeth but are rare anomalies. I once had a model of upper dental arch from a person where the palate was crowded with many erupted teeth (forgot the name of the syndrome). Do you have some scientific literature reference for third teeth? ---
**Author:** ![Walter\_Brown](https://www.rapamycin.news/user_avatar/www.rapamycin.news/walter_brown/32/25586_2.png) [@Walter\_Brown](https://www.rapamycin.news/u/Walter_Brown)\ **Post date:** [June 14, 2024, 8:23pm UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/11 "2024-06-14T20:23:24Z")
None at all, I know nothing about dentistry. I was just quoting from their (hyperlinked) patent on Google. ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [June 14, 2024, 9:52pm UTC](https://www.rapamycin.news/t/update-world-s-first-drug-to-regrow-teeth-enters-clinical-trials/9705/12 "2024-06-14T21:52:40Z")
> [@DrT](#): > > I seem to recall that there are several cases in the literature reporting adults having grown a 3rd set of teeth There is no direct evidence to support the existence of a complete third set of tooth buds in humans. However, it looks like many people have a few extra. Supernumerary teeth are relatively common in the general population. Many papers, here are a couple. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282911/#:~:text=Some%20cases%20of%20supernumerary%20teeth,as%20a%20complimentary%20diagnostic%20test](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282911/#:~:text=Some%20cases%20of%20supernumerary%20teeth,as%20a%20complimentary%20diagnostic%20test). [Aetiology of supernumerary teeth: a literature review - PubMed](https://pubmed.ncbi.nlm.nih.gov/24068489/)