Over what period of time?
I mean I use low dose statin, Zetia and Bempadoic Acid to get my LDL-C/APOB down to the 40 to 45 range from 100 to 200. I feel nothing different, but I know my risk of dying from heart attack has gone down dramatically over the next 20 or 30 years.
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No offense, but your choices of drugs show that you understand much less than you think you do - particularly your choosing a host of GPCR-drugs instead of ādeeperā stuff. Also, ketamine is neurotoxic. You seem to be cruising at the crest of the Dunning Kruger curve here IMO.
The things that I like (at least pertaining to your goals) are just the T3, the EPO, and the MAO inhibitors. Also, with many of the research molecules you are playing with fire.
Also, T3 will only āigniteā you for a couple of days (weeks at most) and once your neurobiochemistry adapts you will be back to only slightly above baseline (speaking from experience).
While MAO-B inhibitors are probably safe for long-term use, we do not know about MAO-A inhibitors. In one study, unselective irreversible MAO inhibitors were most associated with dementia out of all antidepressants? Causality? We do not know.
I talk about this in much more detail in my blog: Desmolysium.com
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The feel indeed.
Even though cardiovascular or cancer seems to get most in the end, it has also gotten many big names in psychedelic/empathogen/counterculture/alt health movement such as Shulgin, Leary, Mckenna etc.
Great idea with the 3 product combo for cardiovascular disease.
Anything for cancer prevention that you recommend?
Perhaps metformin? Nsaid? Melatonin? Anything else?
I donāt have a fixed time frame; it depends on the chemical. Before usage, I read a lot of user reports, which gives me an idea of when I can expect results or effects.
If you are convinced that modulating these specific markers via corresponding chemicals will reduce your risk of dying from a heart attack over the long term, then go ahead. Personally, I have lost interest in chemicals where the primary motivation for ingestion is the hope for a dramatically increased ROI, as some papers claim. There are so many chemicals one can use beforehand, which have demonstrable results in much shorter timeframes.
What do you understand as ādeeperā stuff?
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Ketamine is the āCOSMIC CLEAVERā - the molecule capable of forcefully yet gently splitting the inner observer from the usual everyday references and associations. It elevates the existentiality of existence, creating a dark, almost ominous, yet never frightening space where thoughts can be free from emotional attachment, where memories come and go. It enables deep reflection and contemplation of matters that would otherwise weigh upon oneself.
Interestingly, at higher doses, there are also visible modulations with closed eyes. Dark cathedral-like structures appear, sometimes vast desert landscapes that one seems to travel past. It is a very peaceful and serene place. Music and tones reach an almost crystal-clear purity, yet one never quite knows where they originate from.
Depending on how one utilizes these thoughts and observations and integrates the results of reflection into their life, this experience can have lasting, life-extending effects. Some also use ketamine for depression and chronic pain, and emerging from those can also be a net benefit for life.
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You donāt seem to grasp what T3 is and does; therefore, you had a ābadā experience (even in this case, try again a different way or move on). Thatās why I proposed calling it āIGNITIONā - nobody would ignite an already running car engine multiple times or restart a burning jet engine. When is the right moment to ignite things and for what exactly? Understanding this is key to using it effectively.
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Iāve written about MAO-B Inhibtors above.
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I know your blog; you touch on interesting topics and areas rarely found elsewhere, which gives one the impression that you are open to experimentation and experience. However, your descriptions and articles are boring to read (a sign that you didnāt utilize the creativity-expanding power of nootropics), and also a disruptive (unhealed) aspect of your personality emerges in your articles, manifesting through expressions like āIs it safe to takeā¦ā, āā¦are not toysā, āā¦major risksā, and āā¦will it wreck my brain?ā etc. This kind of extreme safetyism makes reading these kind of articles impossible for me, sorry
For cancer prevention I take NRF2 activators like Sulforaphane, more info here:
- Longevity, Environmental Pollution, and Nrf2 Activation with Dr. Dushani Palliyaguru - The VitaDAO Aging Science Podcast
- Sulforaphane: how to supplement? Forms, dose, brands, timing
- Broccoli Sprouts Improve Health and Extend Lifespan in Rats
- Does Nrf2 Play a Role of a Master Regulator of Mammalian Aging?
- Sulforaphane inhibits mTOR in an NRF2-independent manner
- Does Nrf2 Play a Role of a Master Regulator of Mammalian Aging?
and a low sugar/low processed carb diet and try to keep fasting glucose / A1C in the low range. I take acarbose, SGLT2 inhibitors, etc. on a pulsed basis (experimenting with protocols). No metformin because of its apparent impact on exercise recovery: Metformin and its impact on exercise (on high dose 1700mg, N=46)
Lots of other small anti-cancer approaches:
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An amazing compound!
Over a year ago we got some for our autistic grandson. At 4 he was non-verbal, no eye contact, today he is very engaged and chats up a storm. Runs to us with a hug and calling us Nanny and Grampy!! Short phrases and a few sentences when he feels like it. Itās not a ācureā as he is still autistic but his ability to communicate is so far ahead of where he was. Itās a night and day turn around.
Interestingly, ātoo muchā sulphoraphane makes him overly sensitive to sad things he seeās on TV.
We started taking it about the same time.
The thing I find odd is that we have shared this info with other parents and grandparents of autistic children and get a ho hum attitude back. Only one person asked for more info and they did nothing with that.
Something about leading horses to waterā¦
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Is there a universal reason you are pulsing acarbose and sglt2? Meaning, should I look into this as I currently take both daily.
@Steve_Combi Your meaningful story warmed my heart!
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Itās a complicated issue. Whether reduced metabolic rate is beneficial or not depends on the cause of it. But he isnāt wrong boasting about the low body temperature, pulse and blood pressure. While he may be going a little too far, a little low body temperature, pulse and blood pressure are all good for longevity.
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