# Supplement recommendations for Nocturia? **URL:** \ **Category:** General\ **Created:** [August 8, 2024, 7:59pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469 "2024-08-08T19:59:56Z")\ **Posts on this page:** 20\ **Page:** 1
**Author:** ![lsutiger](https://www.rapamycin.news/user_avatar/www.rapamycin.news/lsutiger/32/387_2.png) [@lsutiger](https://www.rapamycin.news/u/lsutiger)\ **Post date:** [August 8, 2024, 7:59pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/1 "2024-08-08T19:59:56Z")
Given not sleeping well can impact longevity, I felt it was appropriate here to post this question. I’m getting up two to three times a night having to urinate. I was wondering if anyone has tried a prostate related supplement to help with this issue? Would appreciate any recommendations. I have seen a urologist in the past and I do have an enlarged prostate appropriate for my age (60 years old). Thanks! ---
**Author:** ![Steve\_Combi](https://www.rapamycin.news/user_avatar/www.rapamycin.news/steve_combi/32/23927_2.png) [@Steve\_Combi](https://www.rapamycin.news/u/Steve_Combi)\ **Post date:** [August 8, 2024, 9:27pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/2 "2024-08-08T21:27:00Z")
I take webber naturals Super Prostate Advanced Multi-Ingredient Formula Softgels, 180-count daily and it seems to help, although I’ve not had significant issues at night. Usually in bed by 10pm I typically get up around 4am for a quick one and back to sleep until 6:45. I do stop drinking by 7pm and empty the old bladder before bed. ---
**Author:** ![AgentSmith](https://www.rapamycin.news/user_avatar/www.rapamycin.news/agentsmith/32/16937_2.png) [@AgentSmith](https://www.rapamycin.news/u/AgentSmith)\ **Post date:** [August 9, 2024, 1:13am UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/3 "2024-08-09T01:13:10Z")
Some good discussion here: [![](https://img.youtube.com/vi/WTuPdFbGQ1w/maxresdefault.jpg "Is your nocturnal urinary frequency normal? | Peter Attia & Ted Schaeffer") ](https://www.youtube.com/watch?v=WTuPdFbGQ1w) ---
**Author:** ![DrFraser](https://www.rapamycin.news/user_avatar/www.rapamycin.news/drfraser/32/21601_2.png) [@DrFraser](https://www.rapamycin.news/u/DrFraser)\ **Post date:** [August 9, 2024, 1:22am UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/4 "2024-08-09T01:22:41Z")
This is a common issue … I’ve consistently decreased nocturia by 50%+ in men in their 50’s-70’s with an immediate release 5 mg Oxybutynin at bedtime when it is impacting sleep. There are pros and cons - doesn’t impact BPH. It has some anticholinergic activity, more locally - but a short half live. Overall, I feel having improved sleep offsets any risk of short term mild anticholinergic activity on risk of dementia for example. Anyway, I’ve had 5 of these patients in the last month, feedback from 4, the other was an Rx today - but in the last month 4/4 have \>50% reduction in waking up to urinate overnight. Not a cure, but improved symptoms and sleep disturbance markedly. ---
**Author:** ![lsutiger](https://www.rapamycin.news/user_avatar/www.rapamycin.news/lsutiger/32/387_2.png) [@lsutiger](https://www.rapamycin.news/u/lsutiger)\ **Post date:** [August 9, 2024, 2:08am UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/5 "2024-08-09T02:08:13Z")
Thank you Dr. Fraser for this information. Your thoughts on alfuzosin or terazosin vs the Oxybutynin you suggested? ---
**Author:** ![DrFraser](https://www.rapamycin.news/user_avatar/www.rapamycin.news/drfraser/32/21601_2.png) [@DrFraser](https://www.rapamycin.news/u/DrFraser)\ **Post date:** [August 9, 2024, 2:46am UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/6 "2024-08-09T02:46:25Z")
The former 2 have to do with passing urine more easily (with BPH) - I haven’t found those to be valuable for not getting up and urinating at night. ---
**Author:** ![adssx](https://www.rapamycin.news/user_avatar/www.rapamycin.news/adssx/32/14464_2.png) [@adssx](https://www.rapamycin.news/u/adssx)\ **Post date:** [August 9, 2024, 7:17am UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/7 "2024-08-09T07:17:28Z")
I don’t know anything about this topic but a quick Google search led me to: [Calcium Channel Blockers Are Associated with Nocturia in Men Aged 40 Years or Older](https://www.mdpi.com/2077-0383/10/8/1603) (+20% for CCB vs other antihypertensives, not that much but still significant?) Amlodipine in particular seems to increase nocturia. So might be worth switching to another antihypertensive (telmisartan? Indapamide?). Alpha blockers (terazosin, doxazosin) seem to work only (and not a lot) for people with bladder problems: [Management Strategies for Nocturia | Current Urology Reports](https://link.springer.com/article/10.1007/s11934-019-0940-2) ---
**Author:** ![Steve\_Combi](https://www.rapamycin.news/user_avatar/www.rapamycin.news/steve_combi/32/23927_2.png) [@Steve\_Combi](https://www.rapamycin.news/u/Steve_Combi)\ **Post date:** [August 9, 2024, 2:09pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/9 "2024-08-09T14:09:41Z")
I take a CCB just before bedtime. CCB’s can be very important not just for HBP but to help with a condition I’ve had, Coronary vasospasm. It’s important to know why a particular drug is prescribed, while some would look at this one and think HBP, where they may be other issues that the drug has been prescribed for. ---
**Author:** ![adssx](https://www.rapamycin.news/user_avatar/www.rapamycin.news/adssx/32/14464_2.png) [@adssx](https://www.rapamycin.news/u/adssx)\ **Post date:** [August 9, 2024, 2:11pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/10 "2024-08-09T14:11:35Z")
Yes you’re right. Also, non-dihydropyridine CCBs like verapamil or diltiazem are quite different from DHP CCBs (amlodipine and co). I don’t know if they all increase nocturia. ---
**Author:** ![Steve\_Combi](https://www.rapamycin.news/user_avatar/www.rapamycin.news/steve_combi/32/23927_2.png) [@Steve\_Combi](https://www.rapamycin.news/u/Steve_Combi)\ **Post date:** [August 9, 2024, 2:14pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/11 "2024-08-09T14:14:42Z")
I do take amlodipine but only 2.5mg. Still don’t have nocturia. Maybe the low dose? that I stop drinking any fluids by 7pm? Good to know there are alternatives if that did become an issue. ---
**Author:** ![lsutiger](https://www.rapamycin.news/user_avatar/www.rapamycin.news/lsutiger/32/387_2.png) [@lsutiger](https://www.rapamycin.news/u/lsutiger)\ **Post date:** [August 9, 2024, 5:52pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/12 "2024-08-09T17:52:39Z")
AgentSmith, This Attia video was extremely helpful. Thanks for taking the time to share this. ---
**Author:** ![World\_Traveler](https://www.rapamycin.news/user_avatar/www.rapamycin.news/world_traveler/32/32378_2.png) [@World\_Traveler](https://www.rapamycin.news/u/World_Traveler)\ **Post date:** [August 9, 2024, 11:48pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/13 "2024-08-09T23:48:04Z")
Desmopressin concentrates the urine so it takes up less space in bladder. Mentioned in Attia video. Also the BPH drugs mentioned by Dr Fraser helped me. They open up ureter so you can fully empty bladder when you urinate. Alfuzosin is very good. Must take with food. ---
**Author:** ![Curious](https://www.rapamycin.news/user_avatar/www.rapamycin.news/curious/32/9492_2.png) [@Curious](https://www.rapamycin.news/u/Curious)\ **Post date:** [August 10, 2024, 5:25am UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/14 "2024-08-10T05:25:36Z")
> [@World\_Traveler](#): > > Alfuzosin how many hours before sleep. do you prefer to take Alfuzosin? ---
**Author:** ![World\_Traveler](https://www.rapamycin.news/user_avatar/www.rapamycin.news/world_traveler/32/32378_2.png) [@World\_Traveler](https://www.rapamycin.news/u/World_Traveler)\ **Post date:** [August 10, 2024, 5:43am UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/15 "2024-08-10T05:43:14Z")
I take it at lunch because you take with food. It is a slow release formula so it last 24 hrs. 10-20 mg daily works for me. It really helps with urine flow. Also, you need Desmopressin. DESMOPRESSIN (des moe PRESS in) is **a man made form of the hormone vasopressin**. It helps to reduce frequent urination and excessive thirst. Vasopressin is a natural hormone that decreases as we age so this drug is very safe. These two drugs work in combination to reduce the number of trips to bathroom. Good Luck ---
**Author:** ![James\_Rice](https://www.rapamycin.news/user_avatar/www.rapamycin.news/james_rice/32/816_2.png) [@James\_Rice](https://www.rapamycin.news/u/James_Rice)\ **Post date:** [August 11, 2024, 6:57pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/16 "2024-08-11T18:57:28Z")
Had nocturia all my life. Mostly cured with 30 days of oral BPC157 and 30 days of injected BPC157 and TB500, taken for tendon injury (kinda worked on the tendon). ---
**Author:** ![Will](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/w/90ced4/32.png) [@Will](https://www.rapamycin.news/u/Will)\ **Post date:** [August 11, 2024, 8:54pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/17 "2024-08-11T20:54:20Z")
I was getting up 6-8 times a night. Started taking taurine 3g/day and the number of times gradually went down to 1-3. Stop taking it and the number of times started to go back up so I restarted taking it. Then I tried GlyNac (7g/7g) and the and the number of times per night started going back up so I stopped GlyNac. I don’t know why taurine helped or why taurine with GlyNac does not. That is just my experience. ---
**Author:** ![lsutiger](https://www.rapamycin.news/user_avatar/www.rapamycin.news/lsutiger/32/387_2.png) [@lsutiger](https://www.rapamycin.news/u/lsutiger)\ **Post date:** [August 12, 2024, 12:09am UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/18 "2024-08-12T00:09:04Z")
What does of the oral and injectable did you take? ---
**Author:** ![sudiki](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/s/bbe5ce/32.png) [@sudiki](https://www.rapamycin.news/u/sudiki)\ **Post date:** [August 12, 2024, 8:39pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/19 "2024-08-12T20:39:57Z")
> [@Steve\_Combi](#): > > CCB I wish I only had to do that! I’m up to at least 5 times a night. about every 1.5-1.45hrs at a time. I am 65 and have a slightly enlarged prostate. seeing my urologist in 2 wks whom I have been seeing for yrs. (not for BPH, started with hematoria about 15 yrs ago) oops. posted to wrong commnent! ---
**Author:** ![sudiki](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/s/bbe5ce/32.png) [@sudiki](https://www.rapamycin.news/u/sudiki)\ **Post date:** [August 12, 2024, 8:41pm UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/20 "2024-08-12T20:41:54Z")
I wish I only had to do that! I’m up to at least 5 times a night now. about every 1.5-1.45hrs at a time. I am 65 and have a slightly enlarged prostate. seeing my urologist in 2 wks whom I have been seeing for yrs. (not for BPH, started with hematoria about 15 yrs ago) ---
**Author:** ![James\_Rice](https://www.rapamycin.news/user_avatar/www.rapamycin.news/james_rice/32/816_2.png) [@James\_Rice](https://www.rapamycin.news/u/James_Rice)\ **Post date:** [August 13, 2024, 1:46am UTC](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469/21 "2024-08-13T01:46:31Z")
Recommend trying the oral first. Might not be a need to use the injections. . I took 1mg of oral BPC157 per day for 30 days. Swiss Chems $90. Then I injected 1mg of BPC157/TB500 (so .5mg of each) per day for 30 days. Peptide Sciences $350. It comes in freeze-dried powder form, which you reconstitute with some sterile, bacteriostatic water. Then inject with cheap insulin needles. Also no fluids within 3 hours of bedtime. What happened was that my bladder was able to hold a lot more urine without discomfort, so I woke up typically once or twice, vs. maybe 4 times normally. [Next page](https://www.rapamycin.news/t/supplement-recommendations-for-nocturia/15469.md?page=2)