# Spermidine delays aging in humans **URL:** \ **Category:** General\ **Created:** [May 20, 2022, 9:39am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587 "2022-05-20T09:39:10Z")\ **Posts on this page:** 20\ **Page:** 8
**Author:** ![Bicep](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/b/13edae/32.png) [@Bicep](https://www.rapamycin.news/u/Bicep)\ **Post date:** [December 31, 2023, 12:50am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/141 "2023-12-31T00:50:26Z")
I really appreciate this video since my last bad CAC I have decided to stop making half n half yogurt. I wonder if, since we are using bb12, it would still work to add arginine so that spermadine would be made by the bb12. Also just a little flax oil on top since if using trubiotic, that should be made into CLA. I think I’ll try it tonight. ---
**Author:** ![medaura](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/m/c0e974/32.png) [@medaura](https://www.rapamycin.news/u/medaura)\ **Post date:** [December 31, 2023, 1:03am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/142 "2023-12-31T01:03:05Z")
Thank you that’s exactly what I was looking for! ---
**Author:** ![JuanDaw](https://www.rapamycin.news/user_avatar/www.rapamycin.news/juandaw/32/5311_2.png) [@JuanDaw](https://www.rapamycin.news/u/JuanDaw)\ **Post date:** [December 31, 2023, 1:18am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/143 "2023-12-31T01:18:54Z")
I’ll try two versions. One with just her formula, and another fortified with inulin (capsules, water, honey and inulin), hoping to increase the bacteria produced. ---
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [January 26, 2024, 5:05am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/144 "2024-01-26T05:05:33Z")
Spermidine - no positive results in this clinical trial: > ### Findings > > In this randomized clinical trial that included 100 older adults, spermidine supplementation over 12 months did not result in a significant beneficial effect on mnemonic discrimination performance as compared with placebo. > > ### Meaning > > Longer-term spermidine supplementation with an increased daily supply of spermidine by about 10% did not modify memory and other biomarkers in a group of older adults at risk for Alzheimer disease. > **[Effects of Spermidine Supplementation on Cognition and Biomarkers in Older...](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136623/)** > > Does 12-month spermidine supplementation have a beneficial impact on memory performance, as well as on other neuropsychological, behavioral, and physiological parameters, in older individuals with subjective cognitive decline when compared with... ---
**Author:** ![scta123](https://www.rapamycin.news/user_avatar/www.rapamycin.news/scta123/32/9422_2.png) [@scta123](https://www.rapamycin.news/u/scta123)\ **Post date:** [January 26, 2024, 7:51am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/145 "2024-01-26T07:51:58Z")
It was a really low dose of 0.9 mg spermidine. ---
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [January 26, 2024, 7:55am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/146 "2024-01-26T07:55:47Z")
Not exactly… its the standard dose for the Spermidine Life product: > Participants in the verum group received a spermidine-rich dietary supplement extracted from wheat germ (The Longevity Labs). The daily dose of administered plant extract was 750 mg (corresponding to approximately 0.9 mg spermidine, 0.5 mg spermine, 0.2 mg putrescine, \<0.004 mg cadaverine, and 0.12 mg L-ornithine) administered by 6 capsules of 125 mg each. As a comparator condition, the placebo group received 750 mg of microcrystalline cellulose. Baseline assessments were repeated after the 12-month intervention at a postintervention visit ([Supplement 1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136623/#note-ZOI220408-1-s); eMethods 1 in [Supplement 2](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136623/#note-ZOI220408-1-s)). ![Screen Shot 2024-01-25 at 11.56.20 PM](https://www.rapamycin.news/uploads/default/original/3X/b/8/b86cc85e91db5b5e8660149ab2f54feaba7eab54.jpeg) ---
**Author:** ![scta123](https://www.rapamycin.news/user_avatar/www.rapamycin.news/scta123/32/9422_2.png) [@scta123](https://www.rapamycin.news/u/scta123)\ **Post date:** [January 26, 2024, 8:01am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/147 "2024-01-26T08:01:24Z")
> [@RapAdmin](#): > > The daily dose of administered plant extract was 750 mg (corresponding to approximately 0.9 mg spermidine It states in the text that amount of extract corresponds to 0.9mg spermidine… ---
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [January 26, 2024, 8:03am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/148 "2024-01-26T08:03:49Z")
Yes - the typical dose (in Spermidine Life’s product - the market leader) in two capsules of their wheat germ based product is .9mg of spermidine. There are 60 capsules in the bottle, so 30 days worth of dosing at 2 capsules each dose (and about 1mg of the actual chemical spermidine). All I’m saying is that this is the typical dosing that people take of at least this product. So its a respresentative dose of spermidine. Frank Madeo, the primary author of the study, is one of the founders of Spermidine Life - the first company to come out with a spermidine product. ---
**Author:** ![scta123](https://www.rapamycin.news/user_avatar/www.rapamycin.news/scta123/32/9422_2.png) [@scta123](https://www.rapamycin.news/u/scta123)\ **Post date:** [January 26, 2024, 8:09am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/149 "2024-01-26T08:09:51Z")
I am taking around 10-20x this dose daily. I use chlorella in my morning smoothie. > [@Spermidine delays aging in humans](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/130): > > Chlorella algae have quite a lot of spermidine (besides other benefits, amino acids and micronutrients which are all highly bioavailable). The average spermidine content in algae cultivated at 30°C was 1.9 mg/g dry weight (minimum 0.29 mg/g, maximum 2.24 mg/g). ---
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [January 26, 2024, 8:13am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/150 "2024-01-26T08:13:37Z")
So yes, your results may be different than in this study. It would be nice for them to do another study at this higher dose. I wonder if that will happen, given the negative results at these preliminary levels (where they obviously thought they’d get a result)… This issue is that to get 10 or 20X the level, with the typical spermidine capsule product, you’d be taking 20 to 40 capsules a day; which is probably more than most people want to take (most people don’t drink smoothies daily). ---
**Author:** ![scta123](https://www.rapamycin.news/user_avatar/www.rapamycin.news/scta123/32/9422_2.png) [@scta123](https://www.rapamycin.news/u/scta123)\ **Post date:** [January 26, 2024, 8:21am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/151 "2024-01-26T08:21:57Z")
Yes, but I wouldn’t bother with a pill (let alone two pills) that contains only 0.9mg spermidine, I would rather snack on 5g of cheddar for this matter. Or just put 5 gram of parmigiano on my pasta. Do you see how absurdly little this? A typical Italian nona is probably using 15/20 gram of parmigiano on her pastasciutta as we speak. ---
**Author:** ![Curious](https://www.rapamycin.news/user_avatar/www.rapamycin.news/curious/32/9492_2.png) [@Curious](https://www.rapamycin.news/u/Curious)\ **Post date:** [January 26, 2024, 9:08am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/152 "2024-01-26T09:08:53Z")
And mango has quite a bit of spermidine. 3 mg per 100 gr. ---
**Author:** ![Jonas](https://www.rapamycin.news/user_avatar/www.rapamycin.news/jonas/32/11713_2.png) [@Jonas](https://www.rapamycin.news/u/Jonas)\ **Post date:** [January 26, 2024, 5:05pm UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/153 "2024-01-26T17:05:12Z")
“I use chlorella in my morning smoothie.” Is there a brand that you prefer? ---
**Author:** ![matthost](https://www.rapamycin.news/user_avatar/www.rapamycin.news/matthost/32/30225_2.png) [@matthost](https://www.rapamycin.news/u/matthost)\ **Post date:** [January 26, 2024, 5:17pm UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/154 "2024-01-26T17:17:06Z")
Average US intake 8mg, healthy diet estimated to contain 25-30mg, 1 cup of soy milk has ~4mg. So 1mg supplement doesn’t seem significant. Nor does the mnemonic test seem that good for measuring lifespan benefit tbh. ---
**Author:** ![matthost](https://www.rapamycin.news/user_avatar/www.rapamycin.news/matthost/32/30225_2.png) [@matthost](https://www.rapamycin.news/u/matthost)\ **Post date:** [January 26, 2024, 5:22pm UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/155 "2024-01-26T17:22:10Z")
ITP stopping its test because they didn’t detect what they expected in the blood was disappointing. It could be effective by another means, or the rigor of ITP could have shown ineffectiveness which is also valuable data. ---
**Author:** ![CTStan](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/c/b487fb/32.png) [@CTStan](https://www.rapamycin.news/u/CTStan)\ **Post date:** [January 26, 2024, 6:06pm UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/156 "2024-01-26T18:06:34Z")
If I recall correctly , it was 12 mg per day of spermidine that was used in studies that showed benefits. I use powder from Hansen Supplements, 12-15 mg/ day in my coffee. Its possible that spermine, a downstream metabolite of spermidine is the key bioactive effector translating spermidine intake into physiological benefits. In that case, looking for spermidine in blood was the wrong polyamine for ITP to be looking for. ---
**Author:** ![scta123](https://www.rapamycin.news/user_avatar/www.rapamycin.news/scta123/32/9422_2.png) [@scta123](https://www.rapamycin.news/u/scta123)\ **Post date:** [January 26, 2024, 6:56pm UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/157 "2024-01-26T18:56:57Z")
I mostly order [Chlorella Tablets and Powder | PlantPills.co.uk](https://www.plantpills.co.uk/chlorella-tablets) but it has stock problems all the time, so I ordered some other brands as well. The study on spermidine content gave me enough confidence that any chlorella will have enough spermidine. I just make sure it is not Chinese and organic. ---
**Author:** ![JuanDaw](https://www.rapamycin.news/user_avatar/www.rapamycin.news/juandaw/32/5311_2.png) [@JuanDaw](https://www.rapamycin.news/u/JuanDaw)\ **Post date:** [January 26, 2024, 7:22pm UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/158 "2024-01-26T19:22:50Z")
Puny amount (0.9 mg spermidine). Better to eat mushrooms. > **[Content of Biogenic Amines and Physical Properties of Lacto-Fermented Button...](https://www.mdpi.com/2076-3417/12/18/8957)** > > The aim of the study was to assess the content of biogenic amines and physical properties of fruiting bodies of white and brown button mushrooms subjected to the process of controlled lactic acid fermentation. Lactiplantibacillus plantarum 299v with... > Spermidine was present in all samples, but the fresh mushrooms contained significantly higher content of this compound than the processed samples. The level of SPD in the fruiting bodies of the brown button mushrooms was significantly higher than in the white mushroom samples ( **367.22** ± 14.19 and 266.47 ± 13.38 **mg/kg** of mushroom samples, respectively). That is 3.67 mg per ten grams of mushrooms (367.22 / 100 grams to get ten grams). ---
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [February 15, 2024, 5:15am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/159 "2024-02-15T05:15:51Z")
a new compound to watch… > According to the [study](https://www.nature.com/articles/s41589-023-01511-2.epdf?sharing_token=tinziOYW3thRsiEvdhVW-NRgN0jAjWel9jnR3ZoTv0PNeRZiLMYtrcTSSt_cIwjh8W8WC14hnSODS4CPPotKGiYkIS0BFn2YUn4w-T8DKAKZ2u7ZWKtQl4PWXTTh9iHgFHImh15NZxlqqdydAsUbT0cRBJMABOuOkKZxH82Q0Sk%3D) published in _Nature Chemical Biology,_ the new classification of metabolite — acylspermidine — is produced through interactions between sirtuins and spermidines. Sirtuins are an enzyme family that is involved in many essential processes like [DNA damage repair](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/#:~:text=Sirtuins%20play%20a%20vital%20role,oxidative%20stress%20and%20energy%20metabolism.), and spermidine is a compound found in all cells responsible for life-sustaining [functions](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293435/). Researchers found that when the roundworm _Caenorhabditis elegans_ did not produce acylspermidine, its lifespan decreased. This discovery helped to focus research into aging and age-related diseases like cancer, according to Prof. [Robert Weiss](https://www.vet.cornell.edu/research/faculty/robert-weiss-phd), biomedical sciences. > > The researchers first discovered acylspermidines after the Schroeder lab, led by Prof. [Frank Schroeder](https://chemistry.cornell.edu/frank-c-schroeder), chemistry and chemical biology, created a version of _C. elegans_ without the gene responsible for producing sirtuins in the [mitochondria](https://www.genome.gov/genetics-glossary/Mitochondria) — the part of the cell responsible for energy production. This technique of removing genes is known as a [knockout](https://www.genome.gov/genetics-glossary/Knockout#:~:text=A%20knockout%2C%20as%20related%20to,something%20about%20that%20gene's%20function.) and is a tool commonly used to better understand the role of a particular gene. > **[New Metabolite Helps Regulate Lifespan, Cornell Researchers Find - The...](https://cornellsun.com/2024/02/14/new-metabolite-helps-regulate-lifespan-cornell-researchers-find/)** > > Cornell researchers recently discovered a novel metabolite that is connected to the lifespan of a species of roundworm ---
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [August 11, 2024, 6:16am UTC](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587/160 "2024-08-11T06:16:30Z")
# Spermidine is essential for fasting-mediated autophagy and longevity > Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and reduced incidence of cardiovascular and neurodegenerative diseases across species borders. Here, we asked whether the cellular and physiological consequences of caloric restriction and fasting depend on polyamine metabolism. We report that spermidine levels increased upon distinct regimens of fasting or caloric restriction in yeast, flies, mice and human volunteers. Genetic or pharmacological blockade of endogenous spermidine synthesis reduced fasting-induced autophagy in yeast, nematodes and human cells. Furthermore, perturbing the polyamine pathway in vivo abrogated the lifespan- and healthspan-extending effects, as well as the cardioprotective and anti-arthritic consequences of fasting. Mechanistically, spermidine mediated these effects via autophagy induction and hypusination of the translation regulator eIF5A. In summary, the polyamine–hypusination axis emerges as a phylogenetically conserved metabolic control hub for fasting-mediated autophagy enhancement and longevity. Open Access Paper: [https://www.nature.com/articles/s41556-024-01468-x](https://www.nature.com/articles/s41556-024-01468-x) [Previous page](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587.md?page=7) [Next page](https://www.rapamycin.news/t/spermidine-delays-aging-in-humans/1587.md?page=9)