# Normalizing the TruDiagnostic DunedinPace rate of aging by age **URL:** \ **Category:** General\ **Created:** [July 19, 2024, 5:35pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083 "2024-07-19T17:35:19Z")\ **Posts on this page:** 20\ **Page:** 1
**Author:** ![cl-user](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/c/e47c2d/32.png) [@cl-user](https://www.rapamycin.news/u/cl-user)\ **Post date:** [July 19, 2024, 5:35pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/1 "2024-07-19T17:35:20Z")
On the rejuvenation olympics panel, people are ordered by rate of aging irregardless of the age but the average rate of aging does depend on the age. For instance the average rate of aging at 20 is 0.836 so, for a 20 yo, a DunedinPace of 0.85 would be bad (worse than the average) while it would be good for a 60yo. To be able to compare the rate of aging between people of different ages we can normalize the rate of aging to some fixed age like 60. This is what I did in the table below that gives the rate of aging normalized to an age of 60. For instance B.J is 46 yo and has a best rate of aging of 0.64 and if we look at the closest table entry 45/0.65 we get 0.68. That difference does not look very large but it’s enough to have him rank around 20 places lower. | Age | 0.40 | 0.45 | 0.50 | 0.55 | 0.60 | 0.65 | 0.70 | 0.75 | 0.80 | 0.85 | 0.90 | 0.95 | 1.00 | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 20 | 0.45 | 0.50 | 0.56 | 0.61 | 0.67 | 0.73 | 0.78 | 0.84 | 0.89 | 0.95 | 1.00 | 1.06 | 1.12 | | 25 | 0.44 | 0.49 | 0.55 | 0.60 | 0.66 | 0.71 | 0.77 | 0.82 | 0.88 | 0.93 | 0.99 | 1.04 | 1.10 | | 30 | 0.43 | 0.49 | 0.54 | 0.60 | 0.65 | 0.70 | 0.76 | 0.81 | 0.87 | 0.92 | 0.98 | 1.03 | 1.08 | | 35 | 0.43 | 0.48 | 0.53 | 0.59 | 0.64 | 0.69 | 0.75 | 0.80 | 0.86 | 0.91 | 0.96 | 1.02 | 1.07 | | 40 | 0.42 | 0.47 | 0.53 | 0.58 | 0.63 | 0.69 | 0.74 | 0.79 | 0.84 | 0.90 | 0.95 | 1.00 | 1.05 | | 45 | 0.42 | 0.47 | 0.52 | 0.57 | 0.62 | 0.68 | 0.73 | 0.78 | 0.83 | 0.88 | 0.94 | 0.99 | 1.04 | | 50 | 0.41 | 0.46 | 0.51 | 0.56 | 0.62 | 0.67 | 0.72 | 0.77 | 0.82 | 0.87 | 0.92 | 0.98 | 1.03 | | 55 | 0.41 | 0.46 | 0.51 | 0.56 | 0.61 | 0.66 | 0.71 | 0.76 | 0.81 | 0.86 | 0.91 | 0.96 | 1.01 | | 60 | 0.40 | 0.45 | 0.50 | 0.55 | 0.60 | 0.65 | 0.70 | 0.75 | 0.80 | 0.85 | 0.90 | 0.95 | 1.00 | | 65 | 0.39 | 0.44 | 0.49 | 0.54 | 0.59 | 0.64 | 0.69 | 0.74 | 0.79 | 0.84 | 0.89 | 0.94 | 0.99 | | 70 | 0.39 | 0.44 | 0.49 | 0.54 | 0.58 | 0.63 | 0.68 | 0.73 | 0.78 | 0.83 | 0.88 | 0.93 | 0.97 | | 75 | 0.39 | 0.43 | 0.48 | 0.53 | 0.58 | 0.63 | 0.67 | 0.72 | 0.77 | 0.82 | 0.87 | 0.91 | 0.96 | | 80 | 0.38 | 0.43 | 0.48 | 0.52 | 0.57 | 0.62 | 0.67 | 0.71 | 0.76 | 0.81 | 0.86 | 0.90 | 0.95 | | 85 | 0.38 | 0.42 | 0.47 | 0.52 | 0.56 | 0.61 | 0.66 | 0.70 | 0.75 | 0.80 | 0.85 | 0.89 | 0.94 | | 90 | 0.37 | 0.42 | 0.46 | 0.51 | 0.56 | 0.60 | 0.65 | 0.70 | 0.74 | 0.79 | 0.84 | 0.88 | 0.93 | | 95 | 0.37 | 0.41 | 0.46 | 0.50 | 0.55 | 0.60 | 0.64 | 0.69 | 0.73 | 0.78 | 0.83 | 0.87 | 0.92 | | 100 | 0.36 | 0.41 | 0.45 | 0.50 | 0.54 | 0.59 | 0.63 | 0.68 | 0.72 | 0.77 | 0.82 | 0.86 | 0.91 | For those interested in the details, the average by age is: Age \* 0.0024131 + 0.787993 The DunedinPace normalized to 60yo is: DunedinPace \* 0.932779 / (Age \* 0.0024131 + 0.787993) ---
**Author:** ![Steve\_Combi](https://www.rapamycin.news/user_avatar/www.rapamycin.news/steve_combi/32/23927_2.png) [@Steve\_Combi](https://www.rapamycin.news/u/Steve_Combi)\ **Post date:** [July 19, 2024, 6:49pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/2 "2024-07-19T18:49:57Z")
This is exactly what I’ve been wondering about!! My initial thought on this was related to the 12 Hallmarks of Aging and if it was easier to affect those for a younger person than an older person. Your analysis is pretty interesting. My wife Joan Matheson is 67 and her best Pace is 0.74 avg 0.84 She was ranked at # 16 but has dropped to 25 on the leader board. I’m (age 68) ranked # 63 at the moment with a best Pace of 0.94 avg 1.01 It looks like the normalization would not change either her or my result. ---
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [July 19, 2024, 6:54pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/3 "2024-07-19T18:54:56Z")
> [@cl-user](#): > > but the average rate of aging does depend on the age. Is this an established fact? I’ve not looked into this. Have you seen any references/papers that demonstrate this, or is this your theory and calculation based on the results available in this cohort? ---
**Author:** ![cl-user](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/c/e47c2d/32.png) [@cl-user](https://www.rapamycin.news/u/cl-user)\ **Post date:** [July 19, 2024, 7:05pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/4 "2024-07-19T19:05:02Z")
> [@RapAdmin](#): > > Is this an established fact? I’ve not looked into this. Have you seen any references/papers that demonstrate this, or is this your theory and calculation based on the results available in this cohort? It’s from the TruDiagnostic DunedinPace report: ![image](https://www.rapamycin.news/uploads/default/original/3X/4/9/499ca1b41fc783aa54e2fc6f6e3faecae881444e.jpeg) ---
**Author:** ![cl-user](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/c/e47c2d/32.png) [@cl-user](https://www.rapamycin.news/u/cl-user)\ **Post date:** [July 19, 2024, 7:16pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/5 "2024-07-19T19:16:22Z")
> [@Steve\_Combi](#): > > It looks like the normalization would not change either her or my result. You don’t know because the others are not normalized. I took B.J as an example because we know his age. BTW as I normalized to 60, people 60 or close will see no or only a small adjustment. If the people just before your wife in the ranking are younger than her, they will have a worse adjusted pace while she will have a better one. For instance I just googled for Andrea Kladar which is just above your wife and I found one who is a 45yo runner. Assuming she is that woman, her average pace would be adjusted to 0.86 and she would be behind your wife. ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [July 19, 2024, 9:17pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/6 "2024-07-19T21:17:40Z")
This a useful analysis. I found that as my epigenetic age went down the pace of aging went up. That raised some interesting questions. In the end I am concentrating on getting my functional biomakers improved (which includes things like individual hairs moving from being vellus through to terminal and from white to pigmented) Hence particularly as Trudiagnostic seem to have put prices up quite a bit (through levies for international travel) I have stopped doing their tests. ---
**Author:** ![ng0rge](https://www.rapamycin.news/user_avatar/www.rapamycin.news/ng0rge/32/21915_2.png) [@ng0rge](https://www.rapamycin.news/u/ng0rge)\ **Post date:** [July 22, 2024, 4:18pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/7 "2024-07-22T16:18:04Z")
> [@John\_Hemming](#): > > Hence particularly as Trudiagnostic seem to have put prices up quite a bit (through levies for international travel) I have stopped doing their tests. The prices look the same for the US - $229 USD for DunedinPace. Have you quit doing any Epigenetic Age testing? Then, besides your weekly blood tests, what do you consider your most useful tests? I’m following your blog, so I’ve seen your post on Epigenetic Age Changes, and the one on fingernails. You mention functional tests, like hair, and I think I’ve seen you reference the sit-to stand chair test and standing up from sitting on the floor without using your hands. Anyone special insights about testing? ---
**Author:** ![cl-user](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/c/e47c2d/32.png) [@cl-user](https://www.rapamycin.news/u/cl-user)\ **Post date:** [July 22, 2024, 4:30pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/8 "2024-07-22T16:30:49Z")
As some find this not intuitive, I’m presenting that as a conversion table to normalize the DunedinPace of aging between different ages. For instance if we want to compare Dave Pascoe (62) to Bryan Johnson (46) we can normalize BJ’s rate from 46 to 62. For that in the battle below we take the line with age 45 and column 60 and we get 1.04 so we multiply the rate 0.64 by 1.04 and we get 0.67 which is less good than DP who has 0.66 Alternatively we could normalize DP’s rate from 62 to 46 by looking up the starting age (60) in the lines then the target age in the columns (45) and we get 0.96. Multiplying DP’s rate of 0.66 by 0.96 we get 0.63 which is better than BJ’s 0.64. So either way DP’s rate of aging is better than BJ’s one when compensated for age. | age from=\>to | 20 | 25 | 30 | 35 | 40 | 45 | 50 | 55 | 60 | 65 | 70 | 75 | 80 | 85 | 90 | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 20 | 1.00 | 1.01 | 1.03 | 1.04 | 1.06 | 1.07 | 1.09 | 1.10 | 1.12 | 1.13 | 1.14 | 1.16 | 1.17 | 1.19 | 1.20 | | 25 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.06 | 1.07 | 1.09 | 1.10 | 1.11 | 1.13 | 1.14 | 1.16 | 1.17 | 1.18 | | 30 | 0.97 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.06 | 1.07 | 1.08 | 1.10 | 1.11 | 1.13 | 1.14 | 1.15 | 1.17 | | 35 | 0.96 | 0.97 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.06 | 1.07 | 1.08 | 1.10 | 1.11 | 1.12 | 1.14 | 1.15 | | 40 | 0.95 | 0.96 | 0.97 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.05 | 1.07 | 1.08 | 1.10 | 1.11 | 1.12 | 1.14 | | 45 | 0.93 | 0.95 | 0.96 | 0.97 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.05 | 1.07 | 1.08 | 1.09 | 1.11 | 1.12 | | 50 | 0.92 | 0.93 | 0.95 | 0.96 | 0.97 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.05 | 1.07 | 1.08 | 1.09 | 1.11 | | 55 | 0.91 | 0.92 | 0.93 | 0.95 | 0.96 | 0.97 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.05 | 1.07 | 1.08 | 1.09 | | 60 | 0.90 | 0.91 | 0.92 | 0.94 | 0.95 | 0.96 | 0.97 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.05 | 1.06 | 1.08 | | 65 | 0.89 | 0.90 | 0.91 | 0.92 | 0.94 | 0.95 | 0.96 | 0.97 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.05 | 1.06 | | 70 | 0.87 | 0.89 | 0.90 | 0.91 | 0.92 | 0.94 | 0.95 | 0.96 | 0.97 | 0.99 | 1.00 | 1.01 | 1.03 | 1.04 | 1.05 | | 75 | 0.86 | 0.88 | 0.89 | 0.90 | 0.91 | 0.93 | 0.94 | 0.95 | 0.96 | 0.98 | 0.99 | 1.00 | 1.01 | 1.02 | 1.04 | | 80 | 0.85 | 0.86 | 0.88 | 0.89 | 0.90 | 0.91 | 0.93 | 0.94 | 0.95 | 0.96 | 0.98 | 0.99 | 1.00 | 1.01 | 1.02 | | 85 | 0.84 | 0.85 | 0.87 | 0.88 | 0.89 | 0.90 | 0.91 | 0.93 | 0.94 | 0.95 | 0.96 | 0.98 | 0.99 | 1.00 | 1.01 | | 90 | 0.83 | 0.84 | 0.86 | 0.87 | 0.88 | 0.89 | 0.90 | 0.92 | 0.93 | 0.94 | 0.95 | 0.96 | 0.98 | 0.99 | 1.00 | ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [July 22, 2024, 6:09pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/9 "2024-07-22T18:09:01Z")
WIth shipping and taxes it is USD 412.38 per test. I do quite a few tests other than the weekly blood tests although many are just running a fitbit, doing blood pressure and measuring weight. Observing phenotypic changes are perhaps the most important. I don’t think there is enough reliable meaning in the epigenetic tests as yet. ---
**Author:** ![ng0rge](https://www.rapamycin.news/user_avatar/www.rapamycin.news/ng0rge/32/21915_2.png) [@ng0rge](https://www.rapamycin.news/u/ng0rge)\ **Post date:** [July 22, 2024, 6:28pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/10 "2024-07-22T18:28:35Z")
> [@John\_Hemming](#): > > I do quite a few tests other than the weekly blood tests although many are just running a fitbit, doing blood pressure and measuring weight. Observing phenotypic changes are perhaps the most important. Thanks! I’m just doing a final rundown of testing for my baseline before starting rapamycin and acarbose. I have my Polar H10 and getting a sleep score and EliteHRV in the morning, also cardiovascular workout, blood pressure and DexaScan. And grip strength, will do the sit to stand and box jump. Oh, and just came across your thread here: [https://www.rapamycin.news/t/the-civil-war-in-the-biohacking-movement/13408?u=ng0rge](https://www.rapamycin.news/t/the-civil-war-in-the-biohacking-movement/13408) After reading Wikipedia and specially this- " He was beaten into fourth place by the “Silly Party” candidate – the pet dog of the master of St Catherine’s College, Oxford." I just wondered…is that when you started drinking? Or was it the notorious catnapping incident or missing out on the golden rodent? ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [July 22, 2024, 6:38pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/11 "2024-07-22T18:38:08Z")
In my teens I was a heavy metal and punk drummer. That tends to come with Alcohol consumption. ---
**Author:** ![ng0rge](https://www.rapamycin.news/user_avatar/www.rapamycin.news/ng0rge/32/21915_2.png) [@ng0rge](https://www.rapamycin.news/u/ng0rge)\ **Post date:** [July 22, 2024, 6:43pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/12 "2024-07-22T18:43:42Z")
> [@John\_Hemming](#): > > That tends to come with Alcohol consumption. With my cynical attitude, I’d say that about life itself. My conversation with god goes something like this…“you’re going to throw us out into the cold with no blanket?”…God - “No blanket…but here’s alcohol.” Or my favorite Flannery O’Connor quote: “Later he saw Jesus move from tree to tree in the back of his mind, a wild ragged figure motioning him to turn around and come off into the dark where **he might be walking on the water and not know it and then suddenly know it and drown**.” ---
**Author:** ![cl-user](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/c/e47c2d/32.png) [@cl-user](https://www.rapamycin.news/u/cl-user)\ **Post date:** [July 22, 2024, 6:56pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/13 "2024-07-22T18:56:21Z")
TruDiagnostic just sent an email about changing the rules to be more fair. @John_Hemming You are now ranked 40th ![image](https://www.rapamycin.news/uploads/default/original/3X/a/c/acdd23a39c73143dab49060f126dd04be1b40738.png) Which is quite confusing as some have better values and rank way way lower like: ![image](https://www.rapamycin.news/uploads/default/original/3X/b/9/b96f61ff1c6680526f94d5a82d377ab359d53beb.png) Here is what they say: > [@TruDiagnostic](#): > > **Simplified Leaderboard:** > The leaderboard has been redesigned for ease of use and clarity, now ranking by PACE of aging alone for the PACE leaderboard instead of a percentage improvement. I guess we need to wait for them to figure out how to use the “sort” function. ---
**Author:** ![ng0rge](https://www.rapamycin.news/user_avatar/www.rapamycin.news/ng0rge/32/21915_2.png) [@ng0rge](https://www.rapamycin.news/u/ng0rge)\ **Post date:** [July 22, 2024, 7:11pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/14 "2024-07-22T19:11:02Z")
> [@cl-user](#): > > Which is quite confusing as some have better values and rank way way lower like: I think RapaNews users deserve to be favored because we’re obviously smarter. (except for @SNK ) ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [July 22, 2024, 7:23pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/15 "2024-07-22T19:23:10Z")
My best result was 0.78, but as my epiages went down the pace of aging went up. Hence perhaps i should be around 18th there are, however, going to be other people with a range of results. ---
**Author:** ![cl-user](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/c/e47c2d/32.png) [@cl-user](https://www.rapamycin.news/u/cl-user)\ **Post date:** [July 22, 2024, 7:26pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/16 "2024-07-22T19:26:32Z")
TruDiagnostic explicitly says: now ranking by PACE of aging alone for the PACE leaderboard so the other guy should be above you. Maybe they have not updated the web site though. ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [July 22, 2024, 7:29pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/17 "2024-07-22T19:29:25Z")
I think it is because they are using averages actually. ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [July 22, 2024, 7:31pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/18 "2024-07-22T19:31:40Z")
My PACE got worse whilst the epiages came down. I think it may be linked to me reducing citrate supplementation temporarily. ---
**Author:** ![cl-user](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/c/e47c2d/32.png) [@cl-user](https://www.rapamycin.news/u/cl-user)\ **Post date:** [July 22, 2024, 7:32pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/19 "2024-07-22T19:32:02Z")
The other guy has a better average too. ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [July 22, 2024, 7:33pm UTC](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083/20 "2024-07-22T19:33:17Z")
I turned my mobile to landscape and saw more information. [Next page](https://www.rapamycin.news/t/normalizing-the-trudiagnostic-dunedinpace-rate-of-aging-by-age/15083.md?page=2)