# Neutrophil Lymphocyte Ratio (NLR) - how to improve? **URL:** \ **Category:** General\ **Tags:** longevity\ **Created:** [November 18, 2024, 6:01pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401 "2024-11-18T18:01:33Z")\ **Posts on this page:** 15\ **Page:** 2
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [January 11, 2025, 8:26pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/21 "2025-01-11T20:26:57Z")
I tend to be leucopenic even when not on rapa. My last result was 980 n vs 830 l. I think my protocol soups up short transcripts and i dont take any exogenous peptides. ---
**Author:** ![Ulf](https://www.rapamycin.news/user_avatar/www.rapamycin.news/ulf/32/10664_2.png) [@Ulf](https://www.rapamycin.news/u/Ulf)\ **Post date:** [January 11, 2025, 8:53pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/22 "2025-01-11T20:53:16Z")
I did 1.67 mg on three consecutive days. Can hardly get better results, but still ask do you think there is any advantage in spacing it more? ---
**Author:** ![Steve\_Combi](https://www.rapamycin.news/user_avatar/www.rapamycin.news/steve_combi/32/23927_2.png) [@Steve\_Combi](https://www.rapamycin.news/u/Steve_Combi)\ **Post date:** [January 11, 2025, 10:50pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/23 "2025-01-11T22:50:42Z")
> [@Ulf](#): > > any advantage in spacing it more In clinical use, TA-1 is often dosed every day for months but that is for immune compromised individuals. I’d do a more conservative approach like you are doing, 3 to 4 doses a week for 4 weeks and then test. ---
**Author:** ![cl-user](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/c/e47c2d/32.png) [@cl-user](https://www.rapamycin.news/u/cl-user)\ **Post date:** [January 12, 2025, 12:15am UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/24 "2025-01-12T00:15:15Z")
> [@Steve\_Combi](#): > > I’d do a more conservative approach like you are doing, 3 to 4 doses a week for 4 weeks and then test. How long is the improvement expected to last? Can TA-1 be taken for a month every N months? ---
**Author:** ![Ludovic](https://www.rapamycin.news/user_avatar/www.rapamycin.news/ludovic/32/775_2.png) [@Ludovic](https://www.rapamycin.news/u/Ludovic)\ **Post date:** [January 12, 2025, 9:45am UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/25 "2025-01-12T09:45:30Z")
I also don’t gave an optimal NLR and do everything positive mentioned in this topic. ChatGPT suggested low-dose naltrexone, so I started 2mg/day 2 weeks ago. This is a good article about LDN for autoimmunity; > **[How Low Dose Naltrexone Helps Treat Autoimmunity - Barr Center](https://barrcenter.com/how-low-dose-naltrexone-works-in-autoimmunity/)** > > Learn how low dose naltrexone helps boost your autoimmunity with these health tips. ---
**Author:** ![LaraPo](https://www.rapamycin.news/user_avatar/www.rapamycin.news/larapo/32/36179_2.png) [@LaraPo](https://www.rapamycin.news/u/LaraPo)\ **Post date:** [April 14, 2025, 4:38pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/26 "2025-04-14T16:38:29Z")
My neutrophil-to-lymphocyte ratio went down: 2.62/1.43 ‎ = 1.832 (March 10) 2.68/2.17 ‎ = 1.235. (Apr 14). Now worry it’s too low. It could be bc of medication change: replaced Labetalol by Nebivolol, changed to Rapamycin 1 mg/week. Positives: feel overall better, occasional face puffiness is completely gone, some skin spots became lighter, skin in general improved much. Negatives: very slight occasional headache, lower HR (49 daytime and 38 sleep). ---
**Author:** ![Steve\_Combi](https://www.rapamycin.news/user_avatar/www.rapamycin.news/steve_combi/32/23927_2.png) [@Steve\_Combi](https://www.rapamycin.news/u/Steve_Combi)\ **Post date:** [April 14, 2025, 5:21pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/27 "2025-04-14T17:21:44Z")
> [@cl-user](#): > > How long is the improvement expected to last? I’m going to throw some chit at the wall 🙂 I’m going to use my engineering logic on this one. Which is probably different from a bio-science person with expertise in this area. So here goes… 🙂 - TA-1 is one of the 3 hormones the Thymus produces that maturate T-cells. - The Thymus eventually stops producing all the hormones that maturate T-cells (Thymic involution) - T-cells continue to be produced over our life span in an non-maturated condition - T-cells produced during Thymic involution may not be properly or fully maturated? - T-cells produced when Thymic involution is inevitably complete, are not maturated at all. - There are 4 main groups of T-cells with variances within those groups - Each T-cell type has different half-lives My “if \> then” statement 🙂 As Thymosin A1 is a key “maturator” **If** - T-cells become maturated by exogenous use of TA-1 **Then** - the effect of exogenous TA-1 on any T-cell that gets maturated should last for the life of that T-cell as it does for those maturated during the functional life of the rapidly involuting Thymus. > How long do naive T cells live and how are they replenished? A short life span for naive T cells would necessitate faster rates of replenishment, whereas in- creased life span would accommodate slower rates of replenishment. Work in this issue of Immunity by den Braber et al. (2012) examines the longevity of naive T cells. Their data suggest that mechanisms maintaining T cells with naive phenotypes might differ in humans and mice [https://www.cell.com/immunity/pdf/S1074-7613(12)00054-4.pdf](https://www.cell.com/immunity/pdf/S1074-7613(12)00054-4.pdf) ---
**Author:** ![Steve\_Combi](https://www.rapamycin.news/user_avatar/www.rapamycin.news/steve_combi/32/23927_2.png) [@Steve\_Combi](https://www.rapamycin.news/u/Steve_Combi)\ **Post date:** [April 14, 2025, 5:25pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/28 "2025-04-14T17:25:58Z")
And that is why I also use LL 37 when I’m working on my short term immune failures. ---
**Author:** ![Jonas](https://www.rapamycin.news/user_avatar/www.rapamycin.news/jonas/32/11713_2.png) [@Jonas](https://www.rapamycin.news/u/Jonas)\ **Post date:** [April 14, 2025, 10:05pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/29 "2025-04-14T22:05:18Z")
Posted this a while ago, my understanding is you want to be close to 1? N = Neutrophil (innate) L = lymphocytes (acquired and innate) Rapamycin mainly affect Neutrophil (?) @DrFraser As to NLR , my understanding per Gork is you want your L higher than R but the ratio between 0.78-3.5 is considered normal. And FWIW, my own blood works has shown little change in lymphocytes over the course of rapamycin, but my neutrophil to some degree is a function of rapamycin dose (suppressed lower but still normal). Hence, I monitor the trend and ratio of my NLR as a way to gauge my rapamycin dosing. ---
**Author:** ![DrFraser](https://www.rapamycin.news/user_avatar/www.rapamycin.news/drfraser/32/21601_2.png) [@DrFraser](https://www.rapamycin.news/u/DrFraser)\ **Post date:** [April 14, 2025, 10:50pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/30 "2025-04-14T22:50:28Z")
I agree - I think the major impact of Rapamycin is a decreased neutrophil count, and with that, you’ll improve ratio. I’ve seen some people have a little rise in lymphocytes, but not consistently. My average Rapamycin patient has a total WBC of around 3.5. ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [April 15, 2025, 12:13am UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/31 "2025-04-15T00:13:17Z")
AIUI because neutrophils have a short half life intermittent rapamycin hits them quickly ---
**Author:** ![AustraliaLongevity](https://www.rapamycin.news/user_avatar/www.rapamycin.news/australialongevity/32/37552_2.png) [@AustraliaLongevity](https://www.rapamycin.news/u/AustraliaLongevity)\ **Post date:** [June 30, 2025, 2:22pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/32 "2025-06-30T14:22:37Z")
I’ve got mild neutropenia according to my latest blood test. You think rapamycin is a likely cause? I took between 1 and 2 weeks off before the blood test, but I had quite bad mouth sore from the last dose so I think it might have hit me hard. ---
**Author:** ![DrFraser](https://www.rapamycin.news/user_avatar/www.rapamycin.news/drfraser/32/21601_2.png) [@DrFraser](https://www.rapamycin.news/u/DrFraser)\ **Post date:** [June 30, 2025, 2:39pm UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/33 "2025-06-30T14:39:24Z")
I’d guess the 95% tiles of WBC’s of my patients are 2.8-4.5. I still typically see Neutrophils in the 35-60% range. So even with 35% of 2.8, not neutropenic. So it isn’t common to have an ANC of \<1000 cells/mm^3 with rapamycin would be my experience. ---
**Author:** ![Viracocha](https://www.rapamycin.news/user_avatar/www.rapamycin.news/viracocha/32/32553_2.png) [@Viracocha](https://www.rapamycin.news/u/Viracocha)\ **Post date:** [January 28, 2026, 11:37am UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/34 "2026-01-28T11:37:07Z")
Could you give us an update if low dose naltrexone improved your neutrophil to lymphocytes? Thanks! ---
**Author:** ![Ludovic](https://www.rapamycin.news/user_avatar/www.rapamycin.news/ludovic/32/775_2.png) [@Ludovic](https://www.rapamycin.news/u/Ludovic)\ **Post date:** [January 30, 2026, 7:02am UTC](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401/35 "2026-01-30T07:02:38Z")
In april 2025 my NLR score was 3,4. In december it was 2,9. So I do see an improvement [Previous page](https://www.rapamycin.news/t/neutrophil-lymphocyte-ratio-nlr-how-to-improve/17401.md?page=1)