# Lithium Supplementation **URL:** \ **Category:** General\ **Created:** [December 31, 2022, 10:51am UTC](https://www.rapamycin.news/t/lithium-supplementation/4711 "2022-12-31T10:51:22Z")\ **Posts on this page:** 1\ **Showing post:** 32
**Author:** ![JuanDaw](https://www.rapamycin.news/user_avatar/www.rapamycin.news/juandaw/32/5311_2.png) [@JuanDaw](https://www.rapamycin.news/u/JuanDaw)\ **Post date:** [January 28, 2023, 1:33pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/32 "2023-01-28T13:33:40Z")
My post above shows cities with high crime rates per capita. The suggestion of adding lithium to city drinking water was in jest, because there is no showing that those cities’ drinking water have low lithium content. The connection is made based on the untested hypothesis of Australian psychiatrist John Cade. > This theory led to ‘nutri-criminological’ studies which revealed that in areas where the drinking water contained more lithium there were lower serious crime rates and fewer suicides. [Biol Trace Elem Res. 1990 May;25(2):105-13.] My lithium orotate arrived yesterday, in time for my weekend dosing of kaempferol, myricetin, and lithium. I started kaempferol and myricetin the weekend past. This is for my self-experimentation of a substitute for rapamycin (or everolimus), and trametinib (a MEK inhibitor and anti-cancer), as posted below. > [@Yamu Xu co-founder of Lifereversal](https://www.rapamycin.news/t/yamu-xu-co-founder-of-lifereversal/4743/20): > > I have not taken any anti-aging drugs yet. I will try 1) capers (substitute for rapamycin - has more affinity to Everolimus), 2) myricetin supplement or cranberries (trametinib substitute), and 3) lithium. [https://www.researchgate.net/publication/342413079\_Evaluation\_of\_Kaempferol\_as\_AKT\_Dependent\_mTOR\_Regulator\_via\_Targeting\_FKBP-12\_in\_Hepatocellular\_Carcinoma\_An\_In\_silico\_Approach](https://www.researchgate.net/publication/342413079_Evaluation_of_Kaempferol_as_AKT_Dependent_mTOR_Regulator_via_Targeting_FKBP-12_in_Hepatocellular_Carcinoma_An_In_silico_Approach) The docking studies support Kaempferol to be a potential ligand with docking score values of 33.4 (3CQU-3D structure of AKT1)] and 27.3 (2FAP-3D structure of FRB domain of mTOR) respectively as compared to that of standard drug Everolimus with 24.4 (3CQU-3D structure of AKT1) and 20.1 (2FAP-3D structure of FRB domain of mTOR) respectively. Docking studies along with ADMET results shows that Kaempferol has favorable drug likeliness properties and bind to the same active site (site1) of the targeted proteins (3CQU-3D structure of AKT1) and (2FAP-3D structure of FRB domain of mTOR) where the standard drug E… --- _[View the full topic](https://www.rapamycin.news/t/lithium-supplementation/4711)._