# Lithium Supplementation **URL:** \ **Category:** General\ **Created:** [December 31, 2022, 10:51am UTC](https://www.rapamycin.news/t/lithium-supplementation/4711 "2022-12-31T10:51:22Z")\ **Posts on this page:** 20\ **Page:** 2
**Author:** ![Joseph](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/j/dc4da7/32.png) [@Joseph](https://www.rapamycin.news/u/Joseph)\ **Post date:** [January 16, 2023, 1:47pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/21 "2023-01-16T13:47:11Z")
FWIW Review the following; # Serum Lithium Levels: Ideal Time for Sample Collection! Are We Doing it Right? > **[Serum Lithium Levels: Ideal Time for Sample Collection! Are We Doing it Right?](https://pmc.ncbi.nlm.nih.gov/articles/PMC4100432/)** > > Lithium has been the gold standard drug for bipolar disorders. The efficacy of lithium is dose-dependent and reliably correlates with that of serum lithium levels (trough levels). Trough levels are best measured when tested just before the next ... ---
**Author:** ![vegasallen1](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/v/df788c/32.png) [@vegasallen1](https://www.rapamycin.news/u/vegasallen1)\ **Post date:** [January 26, 2023, 5:13am UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/22 "2023-01-26T05:13:44Z")
I buy mine from Life Extension for longevity. The serving size is 1000 mcg of lithium orotate daily. ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [January 26, 2023, 7:13am UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/23 "2023-01-26T07:13:51Z")
I think the serving is actually 1000mcg of elemental lithium provided as orotate. ---
**Author:** ![vegasallen1](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/v/df788c/32.png) [@vegasallen1](https://www.rapamycin.news/u/vegasallen1)\ **Post date:** [January 26, 2023, 4:15pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/24 "2023-01-26T16:15:04Z")
It appears on the label this way: (as lithium orotate). So I see there’s a difference. I just didn’t know about that. ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [January 26, 2023, 7:06pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/25 "2023-01-26T19:06:20Z")
The difference is in how much of the Lithium ion there is. Lithium has an atomic weight of 6.941 Lithium Orotate has a molar weight of 162.03g. For this purpose, therefore, to get a milligram of Lithium you need 162.03/6.941=23.34 milligrams of Lithium Orotate. Labelling is not always that clear, but you are probably taking 23.34 milligrams (give or take a few milligrams) in each capsule. ---
**Author:** ![JuanDaw](https://www.rapamycin.news/user_avatar/www.rapamycin.news/juandaw/32/5311_2.png) [@JuanDaw](https://www.rapamycin.news/u/JuanDaw)\ **Post date:** [January 27, 2023, 11:20pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/26 "2023-01-27T23:20:32Z")
[https://ergo-log.com/lithiumlongevity.html](https://ergo-log.com/lithiumlongevity.html) 7UP used to contain lithium. It was called “lithiated lemon soda”. > In 1949 the Australian psychiatrist John Cade published studies that showed that lithium could be used to treat manias and stabilise bipolar disorders. [Med J Aust. 1949 Sep 3;2(10):349-52.] Cade needed much higher concentrations of lithium to do this than were found in 7UP. But when Cade discovered that even higher concentrations were toxic, the manufacturer of 7UP removed lithium from its product. > Lithium worked so well, however, that Cade initially thought that bipolar disorders were caused by a shortage of lithium. This theory led to ‘nutri-criminological’ studies which revealed that in areas where the drinking water contained more lithium there were lower serious crime rates and fewer suicides. [Biol Trace Elem Res. 1990 May;25(2):105-13.] Tell the mayors of the cities below. > **[Most Violent Cities in America 2026](https://worldpopulationreview.com/us-city-rankings/most-violent-cities-in-america)** > > Discover population, economy, health, and more with the most comprehensive global statistics at your fingertips. The twenty cities with the highest violent crime rates (number of incidents per 100,000 people) are: 1. St. Louis, MO (2,082) 2. Detroit, MI (2,057) 3. Baltimore, MD (2,027) 4. Memphis, TN (2,003) 5. Little Rock, AR (1,634) 6. Milwaukee, WI (1,597) 7. Rockford, IL (1,588) 8. Cleveland, OH (1,557) 9. Stockton, CA (1,415) 10. Albuquerque, NM (1,369) 11. Springfield, MO (1,339) 12. Indianapolis, IN (1,334) 13. Oakland, CA (1,299) 14. San Bernardino, CA (1,291) 15. Anchorage, AK (1,203) 16. Nashville, TN (1,138) 17. Lansing, MI (1,136) 18. New Orleans, LA (1,121) 19. Minneapolis, MN (1,101) 20. Chicago, IL (1,099) ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [January 28, 2023, 3:09am UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/27 "2023-01-28T03:09:59Z")
Lithium is available in many mineral waters throughout the world and is highly bioavailable. One brand sold in the U.S. would only require you to drink 2 liters a day for 1 mg of bioavailable lithium. Of course the other minerals could be problematic for some. Some German waters contain almost 2 mg/L **![](https://lh5.googleusercontent.com/b8HbkbPHdnaEIXnG-6wgvuStQLVRJlaPqpPoFUHKJhfyKPMCXHBpzlysD_Kzs-DwPlv5c4ybLUfxxhASRTttXrO19JyuDr86irj5nPztB_sr2q6OjtFCsWqtSeENguqclqesUblfJWT9zZlE7PHXKSvFgXZPp3xqKAz39YUNYc-A7bmTTJ-P8eqW2rjjcA)** > **[Lithium-Rich Mineral Water is a Highly Bioavailable Lithium Source for Human...](https://pubmed.ncbi.nlm.nih.gov/31051049/)** > > Lithium-rich mineral and medicinal waters may be an important and highly bioavailable lithium source for human consumption. ---
**Author:** ![AlexKChen](https://www.rapamycin.news/user_avatar/www.rapamycin.news/alexkchen/32/385_2.png) [@AlexKChen](https://www.rapamycin.news/u/AlexKChen)\ **Post date:** [January 28, 2023, 3:43am UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/28 "2023-01-28T03:43:57Z")
Negative in mice [https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13479](https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13479) But mice die way too much of cancer, and lithium seems to act on mechanisms independently of cancer ---
**Author:** ![DeStrider](https://www.rapamycin.news/user_avatar/www.rapamycin.news/destrider/32/19418_2.png) [@DeStrider](https://www.rapamycin.news/u/DeStrider)\ **Post date:** [January 28, 2023, 4:07am UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/29 "2023-01-28T04:07:54Z")
I think the data is fairly convincing that lithium supplementation is good for your health, cognition and lifespan. I take lithium orotate every night. ---
**Author:** ![tongMD](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/t/a9adbd/32.png) [@tongMD](https://www.rapamycin.news/u/tongMD)\ **Post date:** [January 28, 2023, 4:13am UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/30 "2023-01-28T04:13:34Z")
Yep, I believe there was a case report in the literature involving negative effects from higher dose orotate supplement form causing a hospitalization somewhere if one wants to look into it. It appears to possibly be close to equivalent. Frankly, I’m not even particularly convinced by the suggested effects of epi evidence for suicide prevention on microdosing lithium at 1-3 mg, but I’m not doubting a potential mood effect on even low doses around 5-15 mg. My take is ~1 mg (spaced out in water from USP grade lithium carbonate IR, wished I had the benefit of ER version) is highly, highly unlikely to cause significant long-term harm if any, with a potential shaky benefit based on a poorly done trial at a slightly lower microdose on AD (with some lack of key details in the trial) that also used lithium carbonate. Not particularly convinced yet on it having enough empircial evidence to significantly increase healthspan or lifespan in humans at the dose I’m taking if it even has any effect in the first place, but the mechanistic gamble in this instance vs potential for harm seems okay in my personal situation. ---
**Author:** ![blsm](https://www.rapamycin.news/user_avatar/www.rapamycin.news/blsm/32/34209_2.png) [@blsm](https://www.rapamycin.news/u/blsm)\ **Post date:** [January 28, 2023, 10:49am UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/31 "2023-01-28T10:49:34Z")
I ordered a 1mg lithium orotate supplement to add to my stack that should arrive today. @JuanDaw I have lived in one of the cities listed in your post for the last 28 years so I suspect my intake has been low. ---
**Author:** ![JuanDaw](https://www.rapamycin.news/user_avatar/www.rapamycin.news/juandaw/32/5311_2.png) [@JuanDaw](https://www.rapamycin.news/u/JuanDaw)\ **Post date:** [January 28, 2023, 1:33pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/32 "2023-01-28T13:33:40Z")
My post above shows cities with high crime rates per capita. The suggestion of adding lithium to city drinking water was in jest, because there is no showing that those cities’ drinking water have low lithium content. The connection is made based on the untested hypothesis of Australian psychiatrist John Cade. > This theory led to ‘nutri-criminological’ studies which revealed that in areas where the drinking water contained more lithium there were lower serious crime rates and fewer suicides. [Biol Trace Elem Res. 1990 May;25(2):105-13.] My lithium orotate arrived yesterday, in time for my weekend dosing of kaempferol, myricetin, and lithium. I started kaempferol and myricetin the weekend past. This is for my self-experimentation of a substitute for rapamycin (or everolimus), and trametinib (a MEK inhibitor and anti-cancer), as posted below. > [@Yamu Xu co-founder of Lifereversal](https://www.rapamycin.news/t/yamu-xu-co-founder-of-lifereversal/4743/20): > > I have not taken any anti-aging drugs yet. I will try 1) capers (substitute for rapamycin - has more affinity to Everolimus), 2) myricetin supplement or cranberries (trametinib substitute), and 3) lithium. [https://www.researchgate.net/publication/342413079\_Evaluation\_of\_Kaempferol\_as\_AKT\_Dependent\_mTOR\_Regulator\_via\_Targeting\_FKBP-12\_in\_Hepatocellular\_Carcinoma\_An\_In\_silico\_Approach](https://www.researchgate.net/publication/342413079_Evaluation_of_Kaempferol_as_AKT_Dependent_mTOR_Regulator_via_Targeting_FKBP-12_in_Hepatocellular_Carcinoma_An_In_silico_Approach) The docking studies support Kaempferol to be a potential ligand with docking score values of 33.4 (3CQU-3D structure of AKT1)] and 27.3 (2FAP-3D structure of FRB domain of mTOR) respectively as compared to that of standard drug Everolimus with 24.4 (3CQU-3D structure of AKT1) and 20.1 (2FAP-3D structure of FRB domain of mTOR) respectively. Docking studies along with ADMET results shows that Kaempferol has favorable drug likeliness properties and bind to the same active site (site1) of the targeted proteins (3CQU-3D structure of AKT1) and (2FAP-3D structure of FRB domain of mTOR) where the standard drug E… ---
**Author:** ![blsm](https://www.rapamycin.news/user_avatar/www.rapamycin.news/blsm/32/34209_2.png) [@blsm](https://www.rapamycin.news/u/blsm)\ **Post date:** [January 28, 2023, 1:46pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/33 "2023-01-28T13:46:39Z")
I ordered it before reading your post so I didn’t decide based on that but I certainly appreciate your clarification. I do believe based on what I’ve read that both places I’ve lived during my lifetime have low groundwater lithium levels. ---
**Author:** ![DeStrider](https://www.rapamycin.news/user_avatar/www.rapamycin.news/destrider/32/19418_2.png) [@DeStrider](https://www.rapamycin.news/u/DeStrider)\ **Post date:** [February 20, 2023, 1:05pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/34 "2023-02-20T13:05:04Z")
> **[Clinical and biological effects of long-term lithium treatment in older...](https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/clinical-and-biological-effects-of-longterm-lithium-treatment-in-older-adults-with-amnestic-mild-cognitive-impairment-randomised-clinical-trial/EF9931A98FFD7FA99F2202C19063EF77)** > > Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial - Volume 215 Issue 5 ![image](https://www.rapamycin.news/uploads/default/original/2X/5/54e26d9ccb50956662974109b86d708c3db50f18.png) ---
**Author:** ![DeStrider](https://www.rapamycin.news/user_avatar/www.rapamycin.news/destrider/32/19418_2.png) [@DeStrider](https://www.rapamycin.news/u/DeStrider)\ **Post date:** [February 20, 2023, 1:05pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/35 "2023-02-20T13:05:58Z")
Trace lithium in Texas tap water is negatively associated with all-cause mortality and premature death (2017) > **[Trace lithium in Texas tap water is negatively associated with all-cause...](https://t.co/n3w0BUkfC5)** > > Lithium in tap water was previously found to have life-extending effects across 18 Japanese municipalities. Using a larger dataset with several Texas counties, our study shows that lithium concentrations in tap water are negatively associated with... ---
**Author:** ![DeStrider](https://www.rapamycin.news/user_avatar/www.rapamycin.news/destrider/32/19418_2.png) [@DeStrider](https://www.rapamycin.news/u/DeStrider)\ **Post date:** [February 20, 2023, 1:06pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/36 "2023-02-20T13:06:35Z")
Low-dose lithium uptake promotes longevity in humans and metazoans (2011) [https://t.co/pldvnIz4CA](https://t.co/pldvnIz4CA) ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [February 23, 2023, 7:52pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/37 "2023-02-23T19:52:51Z")
As promised, I finally had my lithium levels checked. Quite a surprise, makes me wonder if the lithium orotate supplement I am currently taking actually has any lithium in it. FWIW: I am currently taking “Lithium Orotate 5mg, 180 Vegetarian Lithium Capsules” by “Purely Holistic” I think I will go back to the “NCI Advanced Research Dr. Hans Nieper Lithium Orotate Tablets” I have been taking low-dose lithium orotate for decades, so I am completely surprised by the results. ![image](https://www.rapamycin.news/uploads/default/original/2X/6/6b988548aa21e899168f2f927799e0f192adf98d.png) ---
**Author:** ![Livin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/livin/32/6494_2.png) [@Livin](https://www.rapamycin.news/u/Livin)\ **Post date:** [February 23, 2023, 8:32pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/38 "2023-02-23T20:32:32Z")
I take 20mg daily from weyland which is sold on amazon. I should probably test my lithium levels after dosing some time. ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [February 23, 2023, 8:40pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/39 "2023-02-23T20:40:52Z")
When I took 5mg Lithium tablets I had a test result of 0.1 mmol/L. Your result is not clear as it says under 0.3 L when it probably means \<0.3 mmol/L. However, that would be consistent with my result. My result was too high for my purposes as I want a level under 0.05 mmol/L hence I reduced my intake. That reference range is a mental health dosage range not a longevity low dose range. ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [February 23, 2023, 9:16pm UTC](https://www.rapamycin.news/t/lithium-supplementation/4711/40 "2023-02-23T21:16:56Z")
It is \<0.3 mmol/L and yes the range 0.6-1.2 mmol/L is the therapeutic range for treating mental illness. Thanks for keeping me straight. [Previous page](https://www.rapamycin.news/t/lithium-supplementation/4711.md?page=1) [Next page](https://www.rapamycin.news/t/lithium-supplementation/4711.md?page=3)