# LDN & Rapamycin **URL:** \ **Category:** Supplements\ **Tags:** longevity, rapamycin, sirolimus, anti-aging\ **Created:** [January 27, 2023, 8:18pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283 "2023-01-27T20:18:37Z")\ **Posts on this page:** 17\ **Page:** 1
**Author:** ![Biohacker2020](https://www.rapamycin.news/user_avatar/www.rapamycin.news/biohacker2020/32/8646_2.png) [@Biohacker2020](https://www.rapamycin.news/u/Biohacker2020)\ **Post date:** [January 27, 2023, 8:18pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/1 "2023-01-27T20:18:37Z")
Anybody try these 2 at the same time? I’m already in LDN for 10+ years. Wondering if it’s contraindicated? ---
**Author:** ![Paul](https://www.rapamycin.news/user_avatar/www.rapamycin.news/paul/32/640_2.png) [@Paul](https://www.rapamycin.news/u/Paul)\ **Post date:** [January 28, 2023, 3:34am UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/2 "2023-01-28T03:34:07Z")
I’ve been taking rapamycin for 3 years and just started LDN a month ago. no contraindications ---
**Author:** ![sydneyb22](https://www.rapamycin.news/user_avatar/www.rapamycin.news/sydneyb22/32/20459_2.png) [@sydneyb22](https://www.rapamycin.news/u/sydneyb22)\ **Post date:** [January 28, 2023, 9:30pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/3 "2023-01-28T21:30:56Z")
When I saw Dr. Green for rapamycin consult, he said LDN was not contraindicated and noted that both have anti-inflammatory effects. ---
**Author:** ![edotte](https://www.rapamycin.news/user_avatar/www.rapamycin.news/edotte/32/8584_2.png) [@edotte](https://www.rapamycin.news/u/edotte)\ **Post date:** [January 31, 2023, 7:32pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/4 "2023-01-31T19:32:44Z")
Same. I’ve been taking both for over a year. I assume Dr Green told me the same thing, but I don’t specifically remember. (I started LDN independently from agelessrx) ---
**Author:** ![timsbq](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/t/d26b3c/32.png) [@timsbq](https://www.rapamycin.news/u/timsbq)\ **Post date:** [February 1, 2023, 6:33pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/5 "2023-02-01T18:33:26Z")
> [@Paul](#): > > I’ve been taking rapamycin for 3 years and just started LDN a month ago. Hi Paul Has LDN done anything for you that Rapamycin was not aready doing? ---
**Author:** ![Danlalane](https://www.rapamycin.news/user_avatar/www.rapamycin.news/danlalane/32/1615_2.png) [@Danlalane](https://www.rapamycin.news/u/Danlalane)\ **Post date:** [February 1, 2023, 10:31pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/6 "2023-02-01T22:31:28Z")
Take both no issues. ---
**Author:** ![Paul](https://www.rapamycin.news/user_avatar/www.rapamycin.news/paul/32/640_2.png) [@Paul](https://www.rapamycin.news/u/Paul)\ **Post date:** [February 2, 2023, 1:57am UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/7 "2023-02-02T01:57:17Z")
Yes, reduced pain and allowed me to sleep through the night for the first time in 30 years. Haven’t measured any bio makers yet ---
**Author:** ![Biohacker2020](https://www.rapamycin.news/user_avatar/www.rapamycin.news/biohacker2020/32/8646_2.png) [@Biohacker2020](https://www.rapamycin.news/u/Biohacker2020)\ **Post date:** [July 12, 2023, 2:50am UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/8 "2023-07-12T02:50:26Z")
Me too. I find that it works better when I randomize dosing sometimes. ---
**Author:** ![Biohacker2020](https://www.rapamycin.news/user_avatar/www.rapamycin.news/biohacker2020/32/8646_2.png) [@Biohacker2020](https://www.rapamycin.news/u/Biohacker2020)\ **Post date:** [July 12, 2023, 2:50am UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/9 "2023-07-12T02:50:46Z")
I’ve been taking LDN for over 10 years too ---
**Author:** ![Arun](https://www.rapamycin.news/user_avatar/www.rapamycin.news/arun/32/14728_2.png) [@Arun](https://www.rapamycin.news/u/Arun)\ **Post date:** [September 16, 2023, 8:53pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/10 "2023-09-16T20:53:30Z")
I’m looking forward to trying Rapamycin. Are you taking it once weekly? I’m currently on LDN 2-3x per week per this writeup: [Low Dose Naltrexone](http://ldnnow.com/48501/90512.html) " As LDN does not need to be in your system in order for you to reap the benefits, an important question that needs to be asked, is _ **how long will the rebound effect last** _ after taking LDN? For some, the rebound effect can last longer than 24 hours in which case every other day dosing or three times a week (Mon, Wed, Fri) dosing is beneficial." ---
**Author:** ![Joseph\_Lavelle](https://www.rapamycin.news/user_avatar/www.rapamycin.news/joseph_lavelle/32/29812_2.png) [@Joseph\_Lavelle](https://www.rapamycin.news/u/Joseph_Lavelle)\ **Post date:** [September 16, 2023, 9:10pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/11 "2023-09-16T21:10:13Z")
> [@Arun](#): > > Low Dose Naltrexone Thanks for this link. I had not seen this information. I am 22 days into LDN. I’m up to 4.5mg 1x/day. I dose at wakeup. The benefit I sought and have found so far is improved sleep (no more nighttime bathroom visits). I take 3mg rapamycin x GFJ (~10mg rapa equivalent) 1x/week. I weight 200lbs. I have no effects to report except the pleasure of doing something I believe in. ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [September 16, 2023, 11:09pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/12 "2023-09-16T23:09:25Z")
“I dose at wakeup” Odd since most of the references I have read suggested that you take it at bedtime. How did you decide to take it at wakeup? Since I have a drawer full of the stuff and didn’t like its effects taken at bedtime, maybe I will give it a try at wake-up time. Why take LDN at 9pm? The therapeutic dose of LDN is usually between 1.5mg and 4.5mg. Dr. Blades will work with you to help you find your optimal treatment level. LDN is usually taken before bedtime (around 9pm) so that it’s peak effect will take place when your endorphins are at their peak level (around 3-4am). Low Dose Naltrexone Therapy - Blades Wellness > **[Cypress Hormone Replacement Doctor & Med Spa | Blades Wellness Cypress, TX](https://www.bladeswellness.com/)** > > Dr. Carrie Blades is a certified hormone replacement doctor in Cypress, TX. We offer skin rejuvenation, wellness services, and more. Call us today! [https://www.bladeswellness.com](https://www.bladeswellness.com) › naltrexone-therapy ---
**Author:** ![Joseph\_Lavelle](https://www.rapamycin.news/user_avatar/www.rapamycin.news/joseph_lavelle/32/29812_2.png) [@Joseph\_Lavelle](https://www.rapamycin.news/u/Joseph_Lavelle)\ **Post date:** [September 16, 2023, 11:25pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/13 "2023-09-16T23:25:48Z")
@desertshores I started taking LDN at 9pm. When I was taking 1.5mg, that worked well. When I moved up to 3.0mg (on the way to 4.5mg), I started waking up at 2-3am in a state of agitation. Slept badly until I got up. This happened 3 nights in a row. I switched to taking at wakeup to get as far from sleep as possible. It worked perfectly. No more wakeup with agitation. The last 5 nights I have slept through the night without a single bathroom visit. I haven’t done that in a decade. I’ve been on 4.5mg for 2 days now. ---
**Author:** ![Jay](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/j/ed8c4c/32.png) [@Jay](https://www.rapamycin.news/u/Jay)\ **Post date:** [September 17, 2023, 11:22am UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/14 "2023-09-17T11:22:13Z")
desertshores, If you try it in the morning and it works I definitely want to know. Having given it two trials at night with bad results I don’t plan to try it again. And, I still have a box full of it that I’ve considered throwing away. ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [September 17, 2023, 2:36pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/15 "2023-09-17T14:36:12Z")
It doesn’t have too many benefits that can be measured directly except possibly by the CR test which is a measure of inflammation. Most of the things like sleep benefits are subjective. As I said, I have a drawer full of the stuff, so I will try taking it early in the morning. Since I haven’t changed anything else lately maybe it will show up as an improved CR number. If I have any negative side effects from taking it in the morning I will stop. ---
**Author:** ![Joseph\_Lavelle](https://www.rapamycin.news/user_avatar/www.rapamycin.news/joseph_lavelle/32/29812_2.png) [@Joseph\_Lavelle](https://www.rapamycin.news/u/Joseph_Lavelle)\ **Post date:** [September 17, 2023, 4:02pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/16 "2023-09-17T16:02:39Z")
> [@Arun](#): > > " As LDN does not need to be in your system in order for you to reap the benefits, an important question that needs to be asked, is _ **how long will the rebound effect last** _ after taking LDN? For some, the rebound effect can last longer than 24 hours in which case every other day dosing or three times a week (Mon, Wed, Fri) dosing is beneficial." Be sure to check out the link posted by @Arun which says many different dosing schemes are possibly useful…find what works for you, in any: time of day, days per week, etc. ---
**Author:** ![Joseph](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/j/dc4da7/32.png) [@Joseph](https://www.rapamycin.news/u/Joseph)\ **Post date:** [September 17, 2023, 4:55pm UTC](https://www.rapamycin.news/t/ldn-rapamycin/5283/17 "2023-09-17T16:55:28Z")
FWIW The physician who discovered the clinical used of LDN was Bernard Bihari, MD:(1931-2010) Review the following; **“Bernard Bihari, MD: Low-dose Naltrexone for Normalizing Immune System Function”** A PDF copy available at [todayspractitioner.com](http://todayspractitioner.com) > **[Bernard-Bihari-MD-Low-dose-Naltrexone-for-Normalizing-Immune-System-Function-athm\_19\_2\_bihari\_56\_65.pdf](https://todayspractitioner.com/wp-content/uploads/2013/10/Bernard-Bihari-MD-Low-dose-Naltrexone-for-Normalizing-Immune-System-Function-athm_19_2_bihari_56_65.pdf)** > > 349.53 KB Also review; **“Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization”** > **[Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313374/)** > > Naltrexone and naloxone are classical opioid antagonists. In substantially lower than standard doses, they exert different pharmacodynamics. Low-dose naltrexone (LDN), considered in a daily dose of 1 to 5 mg, has been shown to reduce glial...