# Is Dayvigo（lemborexant) a safe sleep pill? **URL:** \ **Category:** Supplements\ **Tags:** longevity, anti-aging, sleep\ **Created:** [September 21, 2025, 10:29pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548 "2025-09-21T22:29:39Z")\ **Posts on this page:** 20\ **Page:** 3
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [March 3, 2026, 9:47pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/45 "2026-03-03T21:47:50Z")
As I said, I am pondering it. I don’t act on everything I ponder. You are correct, it is a Schedule II drug. I am well past my use-by date and am in the camp that old farts should be able to take what they please. 😆 ---
**Author:** ![AustraliaLongevity](https://www.rapamycin.news/user_avatar/www.rapamycin.news/australialongevity/32/37552_2.png) [@AustraliaLongevity](https://www.rapamycin.news/u/AustraliaLongevity)\ **Post date:** [March 3, 2026, 9:59pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/46 "2026-03-03T21:59:37Z")
> [@desertshores](#): > > I want to try Adderall. I just started using a similar product after being diagnosed with ADHD. I think it functions differently for people with ADHD vs people without. I must say it is superior to modafinil. Modafinil at its best would occasionally give me glimpses of what this can do but this is on another level. One thing I will say is I did research into looking at online suppliers and the feedback I saw from people who purchased and had it tested was you’re very often going to get street grade methamphetamine pressed into pills or put into capsules and passed off as Adderall. Now methamphetamine does have very minor legitimate medical use and is prescribed as something called Desoxyn, but this is only for the most extreme cases of treatment resistant ADHD and narcolepsy. Just be careful man. ---
**Author:** ![Kelman](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/k/3ec8ea/32.png) [@Kelman](https://www.rapamycin.news/u/Kelman)\ **Post date:** [March 4, 2026, 1:52pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/47 "2026-03-04T13:52:20Z")
> [@desertshores](#): > > Let us know how it works out. My dayvigo order was already delivered a month ago. Apparently, the package which contained other meds also was never stopped/opened by customs. Haven’t taken/tried it yet though. I’m usually very reluctant to take sedative and addictive meds but I might try a very low dose at some point. ---
**Author:** ![Phillipe](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/p/22d042/32.png) [@Phillipe](https://www.rapamycin.news/u/Phillipe)\ **Post date:** [March 4, 2026, 10:56pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/48 "2026-03-04T22:56:19Z")
Fully in that camp. Indeed, Keith Richards and I are still alive. Proving either resilience or knowing one’s limitations. ---
**Author:** ![ageless64](https://www.rapamycin.news/user_avatar/www.rapamycin.news/ageless64/32/9512_2.png) [@ageless64](https://www.rapamycin.news/u/ageless64)\ **Post date:** [March 13, 2026, 8:45pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/49 "2026-03-13T20:45:22Z")
Inspired by the movie Limitless, I tried Vyvanse, which is a prodrug with similar effects to Adderall. I have also used Modifinel, which had a similar effect on me, without the gitteryness I sometimes got from Vyvance. I like Modafinil better; it’s Schedule IV and easy to get from India. That said, improving my sleep made regular use of Modafinil redundant. Now I’ll use it on the rare occasion that my sleep is disrupted (e.g., jet lag) or when I need focus for something I find no pleasure in, like year-end accounting. ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [March 13, 2026, 9:33pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/50 "2026-03-13T21:33:39Z")
> [@ageless64](#): > > improving my sleep I have no sleep problems from taking 200 mg of modafinil as long as I take it before 11 AM. Sometimes I need to take an additional 100 mg in the afternoon. This does affect my sleep moderately. FWIW: Aubrey de Grey is a big fan of modafinil. He is also a fan of taking L-theanine before bedtime. If you haven’t tried adding L-theanine to your sleep stack, you might want to give it a try. Also, I have found that taking 3 grams of glycine and/or 3 grams of GABA before bedtime on days you take modafinil helps. Everyone’s chemistry is a little different, so YMMV. I do not take NAC with glycine in the evening because it interferes with my sleep. ---
**Author:** ![DavidCary](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/d/49beb7/32.png) [@DavidCary](https://www.rapamycin.news/u/DavidCary)\ **Post date:** [March 14, 2026, 10:18am UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/51 "2026-03-14T10:18:50Z")
Interesting about the NAC and sleep. I just started NAC a week ago and I had some slight increase in activity - more movement and quick wake ups. Didn’t attribute to NAC but maybe so. I was doing glycine alone which does seem to help with sleep quality. I do take mg threonate - didn’t realize that l theanine was so different. My brain just lumped the 2 together but just did some quick research on that thanks to your post. On a similar vain, I took Dayvigo 1st time last night. The biggest thing I noticed is that I didn’t move. I typically start on side and wake on back which might be a bit of apnea even though my home study was negative. I stayed perfectly on my side with Dayvigo. I woke at 3 which isn’t terribly uncommon but I was able to fall asleep right away and again woke on my side. Woke up the typical 90 min later which is good for me. Often I take longer to get back to sleep and don’t get a full cycle. ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [March 14, 2026, 5:08pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/52 "2026-03-14T17:08:13Z")
> [@DavidCary](#): > > I took Dayvigo 1st time last night What dose are you taking? ---
**Author:** ![Jonas](https://www.rapamycin.news/user_avatar/www.rapamycin.news/jonas/32/11713_2.png) [@Jonas](https://www.rapamycin.news/u/Jonas)\ **Post date:** [May 8, 2026, 2:50pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/53 "2026-05-08T14:50:27Z")
Dayvigo at 10mg has the highest REM sleep increase up to 55% That’s impressive. Tested myself and did feel quite refreshing. Question is what is the harm to use it on a sustained basis for someone already use other meds but opt to use Dayvigo as a replacement? In a society of sleeping pill is frowned, Dayvigo is touted as no side effect … nothing is free though. Tim Ferris who long has insomnia problem is a user. ![Screenshot 2026-05-08 at 7.46.41 AM](https://www.rapamycin.news/uploads/default/original/3X/8/7/8750b1f2244cf08e6a753db321c5271111e0a014.png) ---
**Author:** ![Kytexas](https://www.rapamycin.news/user_avatar/www.rapamycin.news/kytexas/32/8480_2.png) [@Kytexas](https://www.rapamycin.news/u/Kytexas)\ **Post date:** [August 18, 2026, 3:47pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/54 "2026-08-18T15:47:15Z")
I received mine ---
**Author:** ![Davin8r](https://www.rapamycin.news/user_avatar/www.rapamycin.news/davin8r/32/30524_2.png) [@Davin8r](https://www.rapamycin.news/u/Davin8r)\ **Post date:** [August 18, 2026, 4:25pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/55 "2026-08-18T16:25:17Z")
Congrats, you lucked out. Not worth the risk IMO of being arrested and convicted of a felony, but each of us has our own risk tolerance. ---
**Author:** ![drgathard](https://www.rapamycin.news/user_avatar/www.rapamycin.news/drgathard/32/29364_2.png) [@drgathard](https://www.rapamycin.news/u/drgathard)\ **Post date:** [August 18, 2026, 5:05pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/56 "2026-08-18T17:05:52Z")
Everything I have read regarding low dose Doxepin indicates that " At **antidepressant doses (75-300 mg)**, doxepin exhibits significant anticholinergic and antinoradrenergic properties that cause dose-limiting side effects" but " At **ultra-low doses (3-6 mg)**, doxepin functions primarily as a **selective H1 histamine receptor antagonist** without engaging the muscarinic cholinergic receptors to a clinically meaningful degree" The **2019 VA/DoD Clinical Practice Guidelines** for chronic insomnia specifically recommend low-dose doxepin (3 or 6 mg) as an option when behavioral interventions are unavailable or refused. The guideline notes that **none of the RCTs found statistically significant differences in adverse event rates between low-dose doxepin and placebo** [https://pubmed.ncbi.nlm.nih.gov/19496739/](https://pubmed.ncbi.nlm.nih.gov/19496739/) [https://pubmed.ncbi.nlm.nih.gov/25364337/](https://pubmed.ncbi.nlm.nih.gov/25364337/) [https://pubmed.ncbi.nlm.nih.gov/32066145/](https://pubmed.ncbi.nlm.nih.gov/32066145/) ---
**Author:** ![drgathard](https://www.rapamycin.news/user_avatar/www.rapamycin.news/drgathard/32/29364_2.png) [@drgathard](https://www.rapamycin.news/u/drgathard)\ **Post date:** [August 18, 2026, 5:18pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/57 "2026-08-18T17:18:11Z")
According to my research it’s not available as an approved medication in most countries. How do you get it? ---
**Author:** ![LukeMV](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/l/7cd45c/32.png) [@LukeMV](https://www.rapamycin.news/u/LukeMV)\ **Post date:** [August 27, 2026, 6:12pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/58 "2026-08-27T18:12:02Z")
Going to be trying Lemborexant (Dayvigo) starting in about a week. I’ll start at 5mg and go up to 10mg if necessary. Couldn’t get access to Suvorexant so I’ll be using this one. Any more reviews on it? Hopefully it works. ---
**Author:** ![Jay](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/j/ed8c4c/32.png) [@Jay](https://www.rapamycin.news/u/Jay)\ **Post date:** [September 2, 2026, 7:06pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/59 "2026-09-02T19:06:45Z")
drgathard, In my experience, doxepin 6 mg, despite having minimal anticholinergic effects at this dose, is reasonably effective for insomnia but causes persistent next-day drowsiness that does not diminish with continued use. Doxepin 3 mg would likely produce less drowsiness, but it was not effective for me. Mirtazapine 15 mg (7.5 mg was ineffective), with essentially no anticholinergic effect, was at least as effective as doxepin and possibly more so. It caused somewhat less next-day drowsiness than doxepin, but still produced significant next-day lethargy. Diphenhydramine 50 mg is similarly effective for me. However, despite its anticholinergic properties, it produces neither noticeable next-day sedation nor noticeable anticholinergic effects in my case. I feel mentally clear and motivated the following day. Consequently, I have switched back to diphenhydramine. Despite the potential long-term concerns associated with chronic use of anticholinergic medications, I consider it a better choice for me than any prescription sleep medication I have tried, including several DORAs. The prescription medications I have tried either work poorly for me or produce side effects that I find more problematic than those associated with diphenhydramine. As an interesting side note, Somaxon Pharmaceuticals, the manufacturer of Silenor, was involved in the development and clinical study of low-dose doxepin for insomnia. This may not be particularly significant, but I find it interesting. Jay ---
**Author:** ![AustraliaLongevity](https://www.rapamycin.news/user_avatar/www.rapamycin.news/australialongevity/32/37552_2.png) [@AustraliaLongevity](https://www.rapamycin.news/u/AustraliaLongevity)\ **Post date:** [September 3, 2026, 12:54am UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/60 "2026-09-03T00:54:50Z")
Any good sources from indian pharma for DORAs? ---
**Author:** ![DavidCary](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/d/49beb7/32.png) [@DavidCary](https://www.rapamycin.news/u/DavidCary)\ **Post date:** [October 9, 2026, 12:11pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/61 "2026-10-09T12:11:17Z")
[Salesgetwell1@gmail.com](mailto:Salesgetwell1@gmail.com) or [getwellmedex@gmail.com](mailto:getwellmedex@gmail.com). They are the same. Awaiting my second shipment. Left Mumbai yesterday ---
**Author:** ![LukeMV](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/l/7cd45c/32.png) [@LukeMV](https://www.rapamycin.news/u/LukeMV)\ **Post date:** [October 9, 2026, 5:36pm UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/62 "2026-10-09T17:36:27Z")
Update: I got a RX from my doctor and tried it for 5 days and it was absolutely horrible. I was pretty much useless for the entire next day up until evening. I would take it at 10pm, go to bed and wake up at like 5:30am. Then I would feel like a zombie until maybe 4pm. After a few days, I had to quit. This was on 5mg too. I tried 2.5mg the last two days and it was still bad. I saw the half life is 17 hours. This drug is not for me. If I am going to try another DORA, it will probably be Dadidorexant since the half life is 8 hours. ---
**Author:** ![Davin8r](https://www.rapamycin.news/user_avatar/www.rapamycin.news/davin8r/32/30524_2.png) [@Davin8r](https://www.rapamycin.news/u/Davin8r)\ **Post date:** [November 1, 2026, 2:53am UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/63 "2026-11-01T02:53:00Z")
Yeah, I don’t know how anyone tolerates a sleep drug with a 17 hour half-life. ---
**Author:** ![DavidCary](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/d/49beb7/32.png) [@DavidCary](https://www.rapamycin.news/u/DavidCary)\ **Post date:** [November 1, 2026, 9:41am UTC](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548/64 "2026-11-01T09:41:21Z")
Because it isn’t a sedative? I am on 10mg of Dayvigo and have no discernible daytime sleepiness. In trials, there is less next day somnolence compared to other classes of sleep medications despite the long half life. I have no specialized knowledge on the orexin system. I would hypothesize that some people with insomnia have overactive orexin systems and this is probably true 24 hours a day. So blocking some of this - even 24 hours a day - helps restore balance and allows better sleep. My experience is that it reduces nighttime wakeups and if they happen, returning to sleep is much easier. N of 2 in my house. Now, there maybe a lot of people who don’t have overactive orexin systems and they may have next day zombiness. As we know, sleep is complex and populations are heterogenous. I would not let the long 1/2 life be a significant barrier to trying something. [Previous page](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548.md?page=2) [Next page](https://www.rapamycin.news/t/is-dayvigo-lemborexant-a-safe-sleep-pill/21548.md?page=4)