# Imeglimin. A new and novel drug thats better than Metformin **URL:** \ **Category:** General\ **Created:** [January 10, 2026, 3:43pm UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036 "2026-01-10T15:43:09Z")\ **Posts on this page:** 10\ **Page:** 9
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [October 29, 2026, 1:44pm UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/164 "2026-10-29T13:44:33Z")
What I find with glucose and insulin is that there is a rapamycin cycle where initially I get insulin resistance and then the insulin goes high and the glucose goes low and then it comes back into balance. I can see that because most of the time rapamycin is out of my system. (6 weekly cycle). ---
**Author:** ![CronosTempi](https://www.rapamycin.news/user_avatar/www.rapamycin.news/cronostempi/32/2504_2.png) [@CronosTempi](https://www.rapamycin.news/u/CronosTempi)\ **Post date:** [October 29, 2026, 3:37pm UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/165 "2026-10-29T15:37:14Z")
Thank you, cl-user, that’s exactly the kind of information I was looking for. Trying to establish a good set of markers to follow, and it’s a lot more than I initially assumed. The further I look into this, the deeper it gets, ha. ---
**Author:** ![egorvj](https://www.rapamycin.news/user_avatar/www.rapamycin.news/egorvj/32/36433_2.png) [@egorvj](https://www.rapamycin.news/u/egorvj)\ **Post date:** [October 30, 2026, 8:12pm UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/166 "2026-10-30T20:12:22Z")
What effects do you expect with such a long cycle, from mechanistic point of view? ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [October 31, 2026, 2:43am UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/167 "2026-10-31T02:43:18Z")
I posted a cycle wirh the results on the forum > [@Second High Dose of Rapamycin topic for results](https://www.rapamycin.news/t/second-high-dose-of-rapamycin-topic-for-results/16926): > > On September 23rd I took 1 packet of biocon and 2 packets of zydus with GFJ and a bit of pomegranate. The Grapefruit was half eaten a while before the rapamycin and half with the rapamycin. This time I had been wearing a CGM (One+) for a few days before taking the rapamycin. It fell off and I got another, I then used a third on schedule, but it stopped uploading on Sunday and that got fixed part way through Tuesday. It will take some work to produce useful reports from this, but I have already done an average glucose chart. I have excluded the days with part data as they will not have useful averages. The results are skewed a bit by alcohol consumption. Alcohol takes down the average glucose. The results, however, still show a useful pattern of Rapamycin initially driving up the average glucose figure. Interestingly it appears that it is the baseline that moves up moreso than the peaks. The body adjusts to produce more insulin, but the rapamycin fades and so at a point when… ---
**Author:** ![egorvj](https://www.rapamycin.news/user_avatar/www.rapamycin.news/egorvj/32/36433_2.png) [@egorvj](https://www.rapamycin.news/u/egorvj)\ **Post date:** [October 31, 2026, 5:57am UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/168 "2026-10-31T05:57:58Z")
Yes, but its all about glucose. I meant that cycle of Rapamycin 6 weeks long - looks like meaningless intervention, which doesn’t change nothing at all. Or does it? I just don’t know but I suppose that you have some point) ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [October 31, 2026, 7:48am UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/169 "2026-10-31T07:48:37Z")
The point about autophagy is that it should include selective mitophagy where the cell destroys inefficient mitochondria with bad mtDNA. The cell then causes the remaining mitochondria to replicate and within the mitochondria as a separate process the mtDNA replicates. Hence at the end of that process you have got rid of some bad mtDNA (for ever). On the other hand you also need mTOR to be active for various positive reasons. Hence the question is how to maximise the removal of bad mtDNA whilst minimising the inhibition of mTOR on an AUC basis. I think the obvious model for that is high dose, but infrequent. It is the intensity of the “spring clean” the gets the lasting positive effects. Important: there are risks with high dose rapamycin and it is also best to start with small cycles of additional mitophagy. Just to say emphasise my answer. Each dose has lasting effects. ---
**Author:** ![egorvj](https://www.rapamycin.news/user_avatar/www.rapamycin.news/egorvj/32/36433_2.png) [@egorvj](https://www.rapamycin.news/u/egorvj)\ **Post date:** [November 2, 2026, 7:31pm UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/170 "2026-11-02T19:31:05Z")
mots-c, urolithin A, spermidine. If you are interested in your mitohealth. I know that you know about them, and maybe even use them, but just as a proposal… Your idea about high and infriquent dosing is interesting. but…we have so many countless myriads of mitochondrias which we need to repair every moment, that rare intervention may left the needle motionless, so to speak… and anyway, you damage your mitochondrias with alcohol so much and on a daily basis, so it looks like you try to spill the glass of water into the full scale forest fire… ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [November 3, 2026, 12:17am UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/171 "2026-11-03T00:17:03Z")
> [@Second High Dose of Rapamycin topic for results](https://www.rapamycin.news/t/second-high-dose-of-rapamycin-topic-for-results/16926/1): > > 1 packet of biocon and 2 packets of zydus with GFJ That would certainly deplete my supply of loperamide. You didn’t experience any bad side effects other than a little increase in glucose levels? ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [November 3, 2026, 12:27am UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/172 "2026-11-03T00:27:51Z")
> [@egorvj](#): > > cycle of Rapamycin 6 weeks long - looks like meaningless intervention There are several reasons someone might adopt that schedule. I am moving towards that schedule myself. In my case, it would be to not depress immune function for long periods. Even without rapamycin, such things as wound healing take longer as we age. From my own experience and following the advice of Michael Blogsklonny, I like high-pulse dosing, but I don’t think that it is wise to do it every week at my age. I couldn’t possibly take the dose that John Hemming takes without experiencing what would amount to dysentery. ---
**Author:** ![John\_Hemming](https://www.rapamycin.news/user_avatar/www.rapamycin.news/john_hemming/32/6542_2.png) [@John\_Hemming](https://www.rapamycin.news/u/John_Hemming)\ **Post date:** [November 3, 2026, 2:48am UTC](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036/173 "2026-11-03T02:48:42Z")
It depends upon what you mean by bad. [Previous page](https://www.rapamycin.news/t/imeglimin-a-new-and-novel-drug-thats-better-than-metformin/23036.md?page=8)