# Glycine+NAC vs Rapamycin

**URL:** <https://www.rapamycin.news/t/glycine-nac-vs-rapamycin/1500>\
**Category:** Supplements\
**Tags:** longevity, rapamycin, anti-aging\
**Created:** [May 13, 2022, 6:29pm UTC](https://www.rapamycin.news/t/glycine-nac-vs-rapamycin/1500 "2022-05-13T18:29:25Z")\
**Posts on this page:** 1\
**Showing post:** 10

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**Author:** ![drgathard](https://www.rapamycin.news/user_avatar/www.rapamycin.news/drgathard/32/29364_2.png) [@drgathard](https://www.rapamycin.news/u/drgathard)\
**Post date:** [May 14, 2022, 2:53am UTC](https://www.rapamycin.news/t/glycine-nac-vs-rapamycin/1500/10 "2022-05-14T02:53:12Z")

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I started Glycine plus NAC several months ago after that article came out. However, after investigating NAC a bit further I decided there was way too much serious negative research associated with NAC. I wish someone would show that the following papers are inaccurate or not applicable. But I have posted them on several sites and gotten no response so I continue to just take Glycine and hope that taking it alone is sufficient.

> **[The antioxidant N-acetylcysteine protects from lung emphysema but induces...](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795405/)**
>
> Oxidative stress is a major contributor to chronic lung diseases. Antioxidants such as N-acetylcysteine (NAC) are broadly viewed as protective molecules that prevent the mutagenic effects of reactive oxygen species. Antioxidants may, however,...

The antioxidant _N_-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice

" NAC treatment decreased lung oxidative damage and cell senescence and protected from lung emphysema but concomitantly induced the development of lung adenocarcinoma in 50% of _JunD_-deficient mice and 10% of aged control mice."

> **[Antioxidants can increase melanoma metastasis in mice - PubMed](https://pubmed.ncbi.nlm.nih.gov/26446958/)**
>
> Antioxidants in the diet and supplements are widely used to protect against cancer, but clinical trials with antioxidants do not support this concept. Some trials show that antioxidants actually increase cancer risk and a study in mice showed that...

Antioxidants can increase melanoma metastasis in mice

"These results demonstrate that antioxidants and the glutathione system play a previously unappreciated role in malignant melanoma progression. "

> **[Increased risk of knee osteoarthritis in patients using oral N-acetylcysteine:...](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418329/)**
>
> Knee osteoarthritis (OA) is known to be a progressive degenerative disorder; however, recent evidence suggests that inflammatory mediators contribute to cartilage degradation. Studies have reported that N-acetylcysteine (NAC) had a promising effect...

Increased risk of knee osteoarthritis in patients using oral N-acetylcysteine: a nationwide cohort study

“Also, in analyses stratified by age group and sex, all subgroups exhibited a significantly higher incidence of knee osteoarthritis (_P_ \< .0001) among NAC users than among NAC nonusers. The use of oral NAC was associated with nearly four-fold increased the risk of knee OA in the young age group.”

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