# Found: a protein that drives ageing without unleashing inflammation

**URL:** <https://www.rapamycin.news/t/found-a-protein-that-drives-ageing-without-unleashing-inflammation/27424>\
**Category:** General\
**Created:** [November 13, 2026, 1:42pm UTC](https://www.rapamycin.news/t/found-a-protein-that-drives-ageing-without-unleashing-inflammation/27424 "2026-11-13T13:42:38Z")\
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**Author:** ![Alpha](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/a/6a8cbe/32.png) [@Alpha](https://www.rapamycin.news/u/Alpha)\
**Post date:** [November 13, 2026, 1:42pm UTC](https://www.rapamycin.news/t/found-a-protein-that-drives-ageing-without-unleashing-inflammation/27424/1 "2026-11-13T13:42:38Z")

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[https://www.nature.com/articles/d41586-026-03638-3](https://www.nature.com/articles/d41586-026-03638-3)

**Aged mice engineered to lack granzyme K have improved heart and liver function and less kidney damage.**

![Light micrograph of liver cirrhosis, showing irregular red tissue regions separated by a network of blue branching bands.](https://media.nature.com/w767/magazine-assets/d41586-026-03638-3/d41586-026-03638-3_53962206.jpg)

Age-related stiffening and scarring of liver tissue (pictured) declined in mice that were bioengineered to lack a certain enzyme. Credit: Ziad M. El-Zaatari/Science Photo Library

Researchers have found an enzyme that drives ageing in the body’s tissues[1](https://www.nature.com/articles/d41586-026-03638-3#ref-CR1). Drugs that reduce the levels of this protein might one day combat the effects of ageing without impairing the body’s immune defences.

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