# Experience with GLP-1s **URL:** \ **Category:** General\ **Created:** [August 4, 2024, 5:18am UTC](https://www.rapamycin.news/t/experience-with-glp-1s/15383 "2024-08-04T05:18:09Z")\ **Posts on this page:** 1\ **Showing post:** 125
**Author:** ![mccoy](https://www.rapamycin.news/user_avatar/www.rapamycin.news/mccoy/32/37100_2.png) [@mccoy](https://www.rapamycin.news/u/mccoy)\ **Post date:** [November 8, 2024, 4:25pm UTC](https://www.rapamycin.news/t/experience-with-glp-1s/15383/125 "2024-11-08T16:25:18Z")
> [@RapMet](#): > > Is it recommended to fast while on GLP-1’s or is that a big no. Asking because it seems easy because of appetite suppression, so might as well stay couple days without food also (unless not recommended for medical reasons)? This issue has been raised in the thread on Longo’s fast-mimicking -diet. It’s a 5-days very low-calories, low protein, vegan stint. Conceptually, it may be harmful. Pra tically it may be not. There are no studies on it apparently. Edit: While re-reading my question, it appears that a low-carb version of the FMD might avoid to overstimulate insulin secretion, especially if simple carbs/sudden peaks are avoided. In Water only, short fasts, there would be no glucose input hence no stimulus to insulin secretion hence no amplification of a glucose signal which is not there. > [@WiseAthletes podcast: Fasting Mimicking Diet for Muscle & Longevity](https://www.rapamycin.news/t/wiseathletes-podcast-fasting-mimicking-diet-for-muscle-longevity/15678/53): > > What would be your scheme of combining FMD + GLP1RAs? i.e., would you use GLP1RAs exactly in concomitance with the FMD, or start one or 2 days prior, and in which dosages, and ending when? I too am interested, since the main obstacle to lifelong adherence is probably the difficulty in tolerating hunger and the perceived sense of deprivation. At least during the 1st phase of FMD. Also, GLP1RAs are known to potentiate glucose-stimulated insulin secretion. Could this cause a risk of hypoglycemia episodes? --- _[View the full topic](https://www.rapamycin.news/t/experience-with-glp-1s/15383)._