# Dietary Inflammation Tied to Muscle Aging **URL:** \ **Category:** General\ **Created:** [July 10, 2022, 9:40pm UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211 "2022-07-10T21:40:55Z")\ **Posts on this page:** 20\ **Page:** 1
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [July 10, 2022, 9:40pm UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/1 "2022-07-10T21:40:56Z")
I wonder if the key mechanism that Rapamycin works on for reduction of muscle aging is via the reductions in inflammation. See new study below, and the well known anti-inflammatory impact of rapamycin in studies at the bottom: **Purpose:** Chronic low-grade systemic inflammation affects muscle protein metabolism. The [dietary inflammatory index (DII®)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416047/) is a tool designed to assess the inflammatory potential of the diet. **Conclusion:** Higher E-DII score is associated with lower muscle mass and muscle strength, and increased likelihood for the combination of low muscle mass and low muscle strength in older adults. This has important implications for healthy aging. New Source Research Paper: ### Association between dietary inflammatory index score and muscle mass and strength in older adults: a study from National Health and Nutrition Examination Survey (NHANES) 1999-2002 [https://pubmed.ncbi.nlm.nih.gov/35809101/](https://pubmed.ncbi.nlm.nih.gov/35809101/) ## Rapamycin and Inflammation: **Results:** We found that rapamycin reduced NLRP3 inflammasome activation in macrophages. Rapamycin reduced NLRP3 inflammasome activation by inhibiting mTOR phosphorylation and NF-κB activation. Moreover, mTOR siRNA inhibited NF-κB activation, leading to the suppression of NLRP3 inflammasome activation. > **[Rapamycin Attenuates High Glucose-Induced Inflammation Through Modulation of...](https://pmc.ncbi.nlm.nih.gov/articles/PMC6831745/)** > > Background: The NLRP3 inflammasome is one of the key contributors to impaired wound healing in diabetes. In this study, we assessed the role of rapamycin on high glucose-induced inflammation in THP-1-derived macrophages and investigated the ... other studies on rapamycin and inflammation reduction: [https://portlandpress.com/bioscirep/article/37/4/BSR20170767/57234/Rapamycin-alleviates-inflammation-and-muscle](https://portlandpress.com/bioscirep/article/37/4/BSR20170767/57234/Rapamycin-alleviates-inflammation-and-muscle) [https://www.sciencedirect.com/science/article/abs/pii/S0304394019302691](https://www.sciencedirect.com/science/article/abs/pii/S0304394019302691) ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [July 10, 2022, 11:29pm UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/2 "2022-07-10T23:29:24Z")
As I have previously posted, I think anti-inflammatories are better for me at my age than anti-oxidants. > **[Anti-inflammatory Dietary Inflammatory Index scores are associated with...](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773655/)** > > Dietary components are important determinants of systemic inflammation; a risk factor for most chronic diseases. The Dietary Inflammatory Index (DII) was developed to assess dietary inflammatory potential. It was hypothesized that anti-inflammatory... ---
**Author:** ![rivasp12](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/r/e47774/32.png) [@rivasp12](https://www.rapamycin.news/u/rivasp12)\ **Post date:** [July 11, 2022, 1:02am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/3 "2022-07-11T01:02:38Z")
Nice studies. There’s really no debating any longer the role of chronic inflammation in all things aging. I’m sure that the anti inflammatory component of rapamycin is yet another attribute. Lycopene also has significant anti inflammatory activity and apparently will lower LDL by about 10% with doses over 25 mg. > **[Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376536/)** > > Although the antioxidative effects of lycopene are generally known, the molecular mechanisms underlying the anti-inflammatory properties of lycopene are not fully elucidated. This study aimed to examine the role and mechanism of lycopene as an... ---
**Author:** ![rivasp12](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/r/e47774/32.png) [@rivasp12](https://www.rapamycin.news/u/rivasp12)\ **Post date:** [July 11, 2022, 1:03am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/4 "2022-07-11T01:03:39Z")
It would be interesting to come up with a list of the best dietary and anti inflammatory supplements. ---
**Author:** ![desertshores](https://www.rapamycin.news/user_avatar/www.rapamycin.news/desertshores/32/17120_2.png) [@desertshores](https://www.rapamycin.news/u/desertshores)\ **Post date:** [July 11, 2022, 1:53am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/5 "2022-07-11T01:53:03Z")
I Will start with two, one I really like and one I personally detest in spite of the evidence. Boswellia serrata, Indian frankincense, is one amazing supplement for some people. Strangely it is most effective for knee pain. Curcumin: I really don’t like it because it doesn’t like me. I have given it a try many times over the years with different brands, doses, and regimens because it is so highly touted. It only ever gave me heartburn, etc. regardless of taking it on a full stomach or empty stomach. It never produced any discernible results for me. And in addition, I don’t like curried foods. A fairly recent meta-analysis of Boswellia serrata: Based on current evidence, Boswellia and its extract may be an effective and safe treatment option for patient with OA, and the recommended duration of treatment with Boswellia and its extract is at least 4 weeks. > **[Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients:...](https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-020-02985-6?crsi=6624969174&cicada_org_src=healthwebmagazine.com&cicada_org_mdm=direct)** > > Background Osteoarthritis (OA) is the commonest form of inflammatory joint disease. Unfortunately, to date, there is no appropriate treatment for OA. Boswellia serrata was considered as a potent anti-inflammatory, anti-arthritic and analgesic agent... and Boswellia is used to: Treat arthritis Help with asthma Treat colitis (inflammation of your colon) Help with inflammation (swelling and redness) Help reduce fluid cerebral edema (brain swelling) after radiotherapy, in patients with brain tumors Help reduce skin damage due to radiotherapy, in breast cancer patients. > **[Boswellia](https://www.mskcc.org/cancer-care/integrative-medicine/herbs/boswellia)** > > The resin of Boswellia tree, known as frankincense or olibanum, is used in Ayurveda to treat arthritis, ulcerative colitis, coughs, sores, asthma, and for wound healing. ---
**Author:** ![Maveric78](https://www.rapamycin.news/user_avatar/www.rapamycin.news/maveric78/32/1638_2.png) [@Maveric78](https://www.rapamycin.news/u/Maveric78)\ **Post date:** [July 11, 2022, 4:50am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/6 "2022-07-11T04:50:03Z")
EVOO contains oleocanthol which has anti inflammatory properties: > **[Oleocanthal, a Phenolic Derived from Virgin Olive Oil: A Review of the...](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139846/)** > > Virgin olive oil (VOO) is credited as being one of many healthful components of the Mediterranean diet. Mediterranean populations experience reduced incidence of chronic inflammatory disease states and VOO is readily consumed as part of an everyday... ---
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [July 11, 2022, 5:18am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/7 "2022-07-11T05:18:11Z")
> [@desertshores](#): > > Curcumin: I really don’t like it because it doesn’t like me. Its interesting… I did run into this that supports your idea, but interestingly did not find much result from rapamycin in this application. [https://pubmed.ncbi.nlm.nih.gov/30037344/](https://pubmed.ncbi.nlm.nih.gov/30037344/) ---
**Author:** ![DeStrider](https://www.rapamycin.news/user_avatar/www.rapamycin.news/destrider/32/19418_2.png) [@DeStrider](https://www.rapamycin.news/u/DeStrider)\ **Post date:** [July 11, 2022, 7:02am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/8 "2022-07-11T07:02:06Z")
I do believe inflammation is the key to biological aging. I took an epigenetic spit test in January two weeks after I got my 3rd COVID booster and the result was that I was 19 years older than my chronological age (66 vs 47). I called up the lab to protest and they told me the vaccine was the reason as I had a lot of inflammation (2 weeks is supposedly the high point for vaccine inflammation and antibodies). They offered me a free test to make up for the one that gave me such a wrong answer. I’m curious what the new results will be. As an aside, I plugged my blood test results from February into Aging.ai and my blood is only 26 years old. So if you average my blood age and spit age together, you get my chronological age. The truth is probably somewhere in between the extremes… ---
**Author:** ![rivasp12](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/r/e47774/32.png) [@rivasp12](https://www.rapamycin.news/u/rivasp12)\ **Post date:** [July 11, 2022, 12:58pm UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/9 "2022-07-11T12:58:20Z")
Boswellia and curcumin are always on the list. I take straight frankincense as liquid drops from Hawaii pharm . I like cinnamon and ginger as very good anti inflammatory agents that have multiple benefits. > **[Ginger--an herbal medicinal product with broad anti-inflammatory actions -...](https://pubmed.ncbi.nlm.nih.gov/16117603/)** > > The anti-inflammatory properties of ginger have been known and valued for centuries. During the past 25 years, many laboratories have provided scientific support for the long-held belief that ginger contains constituents with antiinflammatory... ---
**Author:** ![Arhu](https://www.rapamycin.news/user_avatar/www.rapamycin.news/arhu/32/40334_2.png) [@Arhu](https://www.rapamycin.news/u/Arhu)\ **Post date:** [July 11, 2022, 1:26pm UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/10 "2022-07-11T13:26:05Z")
That’s probably just a correlation: to gain or even maintain muscle mass you need a high quality protein rich diet and exercise. Muscle and exercise also make you more insulin sensitive which reduces inflammation ---
**Author:** ![rivasp12](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/r/e47774/32.png) [@rivasp12](https://www.rapamycin.news/u/rivasp12)\ **Post date:** [July 11, 2022, 1:29pm UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/11 "2022-07-11T13:29:36Z")
But do you need a high protein diet to maintain muscle mass or just a regular resistance training regimen? ---
**Author:** ![Arhu](https://www.rapamycin.news/user_avatar/www.rapamycin.news/arhu/32/40334_2.png) [@Arhu](https://www.rapamycin.news/u/Arhu)\ **Post date:** [July 11, 2022, 1:38pm UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/12 "2022-07-11T13:38:25Z")
During a cut it’s advised to increase protein intake as this will ensure you’ll lose less muscle ---
**Author:** ![RapAdmin](https://www.rapamycin.news/user_avatar/www.rapamycin.news/rapadmin/32/377_2.png) [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Post date:** [July 11, 2022, 6:11pm UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/13 "2022-07-11T18:11:42Z")
More potentially relevant research: ### Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation ### Results ACA, Rapa, and 17aE2 (in males, but not in females) oppose age-related increases in the MEK1- ERK1/2-MNK1/2 cascade, and thus reduce phosphorylation of eIF4E, a key component of cap-dependent translation. In parallel, these treatments (in both sexes) reduce age-related increases in the MEK3-p38MAPK-MK2 pathway, to decrease levels of the acute phase response proteins involved in inflammation. ### Conclusion Each of three drugs converges on the regulation of both the ERK1/2 signaling pathway and the p38-MAPK pathway. The changes induced by treatments in ERK1/2 signaling are seen in both sexes, but the 17aE2 effects are male-specific, consistent with the effects on lifespan. However, the inhibition of age-dependent p38MAPK pathways and acute phase responses is triggered in both sexes by all three drugs, suggesting new approaches to prevention or reversal of age-related inflammatory changes in a clinical setting independent of lifespan effects. > **[Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the...](https://pmc.ncbi.nlm.nih.gov/articles/PMC8805398/)** > > Rapamycin (Rapa), acarbose (ACA), and 17α-estradiol (17aE2, males only) have health benefits that increase lifespan of mice. Little is known about how these three agents alter the network of pathways downstream of insulin/IGF1 signals as well as ... ---
**Author:** ![MAC](https://www.rapamycin.news/user_avatar/www.rapamycin.news/mac/32/7620_2.png) [@MAC](https://www.rapamycin.news/u/MAC)\ **Post date:** [July 11, 2022, 7:29pm UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/14 "2022-07-11T19:29:44Z")
This is good, more fundamental understanding of intracellular pathways and immune response activated to deliver longevity enhancements. Although rapamycin might deliver the highest longevity benefit in mouse models, applying it to humans is fraught with dosing/side effects issues, potentially severely limiting translation. Perhaps one of these other molecules (and new ones discovered that target these pathways) will deliver BOTH significantly improved lifespan and far lesser side effects…in human translation. Furthermore, once again, _ **liver and kidney were tissue signalling hubs** _: “To evaluate effects of age and anti-aging drugs on the MEK1 kinase cascade, we collected lysates from livers and kidneys” ---
**Author:** ![MAC](https://www.rapamycin.news/user_avatar/www.rapamycin.news/mac/32/7620_2.png) [@MAC](https://www.rapamycin.news/u/MAC)\ **Post date:** [July 12, 2022, 12:37am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/15 "2022-07-12T00:37:29Z")
> [@Maveric78](#): > > EVOO contains oleocanthol which has anti inflammatory properties: Indeed, this is the magic phenol molecule in EVOO. When I look for EVOO, I look for highest oleocanthal, normally only buy from vendors who can produce 3rd party lab analysis. You can tell a high oleocanthal EVOO by tasting it…if it dosen’t burn your throat, it’s not high level. I really go out of my way to procure high oleocanthal grades, typically come from Greece/Cyprus/Italy. There are have been many intervention studies using EVOO. A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study [https://pubmed.ncbi.nlm.nih.gov/33044178/](https://pubmed.ncbi.nlm.nih.gov/33044178/) Critical Review on the Significance of Olive Phytochemicals in Plant Physiology and Human Health > **[Critical Review on the Significance of Olive Phytochemicals in Plant...](https://pmc.ncbi.nlm.nih.gov/articles/PMC6150410/)** > > Olive oil displays remarkable organoleptic and nutritional features, which turn it into a foodstuff appreciated by consumers, and a basic component of the Mediterranean diet. Indeed, the noticed benefits of including olive oil in the diet have been... ---
**Author:** ![MAC](https://www.rapamycin.news/user_avatar/www.rapamycin.news/mac/32/7620_2.png) [@MAC](https://www.rapamycin.news/u/MAC)\ **Post date:** [July 12, 2022, 1:03am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/16 "2022-07-12T01:03:16Z")
> [@rivasp12](#): > > But do you need a high protein diet to maintain muscle mass or just a regular resistance training regimen? You absolutely do NOT need a high protein diet to maintain muscle mass. In fact, Dr B says “amino acids don’t build muscles, resistance exercise does”, and the science backs this. I eat approx 50g/day (a far lower intake compared to historical in the switch to a ketogenic diet) but do daily 45 minutes of resistance exercise. Massive growth in my musculature…they didn’t come from eating extra protein (in fact, eating LESS), 100% from resistance exercise. **Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review** [https://www.mdpi.com/2073-4409/9/7/1658](https://www.mdpi.com/2073-4409/9/7/1658) Mechanical load can build muscle several ways. A. myofiber hypertrophy, (B) myofiber splitting or hyperplasia, or (C) longitudinal growth of myofibers that exhibit intrafascicular terminations ![Screen Shot 2022-07-11 at 8.55.12 PM](https://www.rapamycin.news/uploads/default/original/2X/3/307edcc85cace532c019f5b2f6292a97b43c95ee.jpeg) Why exercise builds muscles: titin mechanosensing controls skeletal muscle growth under load [https://sci-hub.se/https://doi.org/10.1016/j.bpj.2021.07.023](https://sci-hub.se/https://doi.org/10.1016/j.bpj.2021.07.023) ![Screen Shot 2022-07-11 at 9.02.07 PM](https://www.rapamycin.news/uploads/default/original/2X/5/572c30c689314ad0d82d3ddcb1daf34f30336351.jpeg) ---
**Author:** ![rivasp12](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/r/e47774/32.png) [@rivasp12](https://www.rapamycin.news/u/rivasp12)\ **Post date:** [July 12, 2022, 1:06am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/17 "2022-07-12T01:06:16Z")
Yeah, I suspected as much. The data on creatine is getting tempting though. ---
**Author:** ![MAC](https://www.rapamycin.news/user_avatar/www.rapamycin.news/mac/32/7620_2.png) [@MAC](https://www.rapamycin.news/u/MAC)\ **Post date:** [July 12, 2022, 1:13am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/18 "2022-07-12T01:13:20Z")
Muscle building is as old as fire…the wheel dosen’t need re-inventing, or extra BCAA or fancy amino acids. Just load it!! ---
**Author:** ![rivasp12](https://www.rapamycin.news/letter_avatar_proxy/v4/letter/r/e47774/32.png) [@rivasp12](https://www.rapamycin.news/u/rivasp12)\ **Post date:** [July 12, 2022, 1:15am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/19 "2022-07-12T01:15:04Z")
Would you say Liokareas is the best? ---
**Author:** ![MAC](https://www.rapamycin.news/user_avatar/www.rapamycin.news/mac/32/7620_2.png) [@MAC](https://www.rapamycin.news/u/MAC)\ **Post date:** [July 12, 2022, 1:29am UTC](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211/20 "2022-07-12T01:29:32Z")
> [@rivasp12](#): > > Liokareas Is this an olive oil? I bought a case of this EVOO below (not cheap), it has SUPER high oleocanthal. [https://www.yannisolivegrove.gr/](https://www.yannisolivegrove.gr/) I think of EVOO as compared to wine; with much better value and health benefits than a bottle of good wine. A bottle of good wine is expensive and FLEETING, with almost no health effects (arguably, negative health effects). Yet this bottle of EVOO, cheaper by the mL than a good bottle of wine lasts me a LONG time and is infinitely higher in health benefits. Looks like amazon offers it now: > **[Amazon.com: Yanni's Finest Early Harvest Greek Extra Virgin Olive Oil, 500ml :...](https://www.amazon.com/dp/B07KX5D552)** > > Our family believes your family deserves the best, and that's why we take the growing, harvesting, and production of extra virgin olive oil (EVOO) very seriously. We strongly believe that to produce EVOO of the highest quality; one needs a deep... ![Screen Shot 2022-07-11 at 9.27.17 PM](https://www.rapamycin.news/uploads/default/original/2X/d/d4baa2568624e90c62a0752b8f8071fb7a7726ed.png) [Next page](https://www.rapamycin.news/t/dietary-inflammation-tied-to-muscle-aging/2211.md?page=2)