# Latest **URL:** https://www.rapamycin.news/latest.md?page=2 [Latest](https://www.rapamycin.news/latest.md) · [Categories](https://www.rapamycin.news/categories.md) · [Tags](https://www.rapamycin.news/tags.md) **Page:** 3 --- ## [Simon Hill, MSc BSc, The Proof Podcast - Videos and Summaries](https://www.rapamycin.news/t/simon-hill-msc-bsc-the-proof-podcast-videos-and-summaries/26365)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 6\ **Last updated:** [November 3, 2026, 2:32am UTC](https://www.rapamycin.news/t/simon-hill-msc-bsc-the-proof-podcast-videos-and-summaries/26365 "2026-11-03T02:32:25Z")
How to switch your body from burning sugar to fat | Metabolic Masterclass | EP#429 I. Executive Summary Metabolic health represents the cellular capacity to efficiently oxidize substrates—fatty acids and glucose—within mitochondria to sustain bioenergetic homeostasis. Cardiometabolic diseases, including type 2 diabetes (T2D), metabolic dysfunction-associated steatotic liver disease (… --- ## [Life Expectancy in the USA and Around the world](https://www.rapamycin.news/t/life-expectancy-in-the-usa-and-around-the-world/2915)
**Author:** [@Agetron](https://www.rapamycin.news/u/Agetron)\ **Replies:** 587\ **Last updated:** [November 3, 2026, 1:36am UTC](https://www.rapamycin.news/t/life-expectancy-in-the-usa-and-around-the-world/2915 "2026-11-03T01:36:19Z")
“The longevity gap between men and women also grew by a couple of months in 2021. American women can now expect to live 79.1 years, almost six years longer than men, whose average life expectancy was 73.2 last year, according to the new data.” Overall, the sharpest two-year decline in nearly 100 years - from average of 79 years to 73 years – a 6.5 years drop. Link: https://www.nytimes.com/2022… --- ## [Peter Attia Podcasts - Transcripts / Analysis](https://www.rapamycin.news/t/peter-attia-podcasts-transcripts-analysis/22648)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 26\ **Last updated:** [November 2, 2026, 11:25pm UTC](https://www.rapamycin.news/t/peter-attia-podcasts-transcripts-analysis/22648 "2026-11-02T23:25:29Z")
The ketogenic diet, ketosis, and hyperbaric oxygen: weight loss, cognition, cancer, and more AI summary: Based on the transcript provided featuring Dom D’Agostino and Peter Attia, here is the summary and analysis. A. Executive Summary In this episode of The Drive, Peter Attia and Dr. Dom D’Agostino discuss the evolution of the ketogenic diet from a niche epilepsy treatment to a broa… --- ## [Sheekey and a take on rejuvenation](https://www.rapamycin.news/t/sheekey-and-a-take-on-rejuvenation/25866)
**Author:** [@Curious](https://www.rapamycin.news/u/Curious)\ **Replies:** 3\ **Last updated:** [November 2, 2026, 9:44pm UTC](https://www.rapamycin.news/t/sheekey-and-a-take-on-rejuvenation/25866 "2026-11-02T21:44:25Z")
She really dives into the science in only 9 min and 30 sec. --- ## [ELF Score as a Marker for Systemic Inflammation and Fibrosis](https://www.rapamycin.news/t/elf-score-as-a-marker-for-systemic-inflammation-and-fibrosis/27270)
**Author:** [@cronoslogical](https://www.rapamycin.news/u/cronoslogical)\ **Replies:** 6\ **Last updated:** [November 2, 2026, 9:42pm UTC](https://www.rapamycin.news/t/elf-score-as-a-marker-for-systemic-inflammation-and-fibrosis/27270 "2026-11-02T21:42:46Z")
Has anyone had an ELF test done? Although this test is ordered to screen for liver fibrosis, it is a measure of systemic inflammation and fibrosis which, as we know, drives all aspect of aging. Unfortunately, it costs \>$ 800 out of pocket, so unaffordable for me. After learning about what ELF measures, I wondered why drugs such as Pirfenidone, montelukast, and others which target fibrotic, infl… --- ## [Fast Walkers, Slower Aging: How 'Super Mover' Octogenarians Outpace Cognitive Decline](https://www.rapamycin.news/t/fast-walkers-slower-aging-how-super-mover-octogenarians-outpace-cognitive-decline/26938)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 1\ **Last updated:** [November 2, 2026, 9:32pm UTC](https://www.rapamycin.news/t/fast-walkers-slower-aging-how-super-mover-octogenarians-outpace-cognitive-decline/26938 "2026-11-02T21:32:26Z")
This retrospective multicohort study investigates “super movers,” defined as adults 80 years and older with exceptional gait speeds, to determine their risk of cognitive decline and neurodegeneration. Across thousands of participants, researchers found that these fast walkers possess a 51 percent lower risk of developing cognitive impairment and exhibit preserved hippocampal volume, despite hav… --- ## [Train Your Recovery: Why Bouncing Back May Matter More Than Your Biological Age Score](https://www.rapamycin.news/t/train-your-recovery-why-bouncing-back-may-matter-more-than-your-biological-age-score/27332)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 1\ **Last updated:** [November 2, 2026, 8:23pm UTC](https://www.rapamycin.news/t/train-your-recovery-why-bouncing-back-may-matter-more-than-your-biological-age-score/27332 "2026-11-02T20:23:46Z")
Researchers from Swedish Medical Center and the University of Denver argue that aging is best understood as a progressive loss of “biological self-correction”: the body’s ability to sense a disturbance, mount a proportionate response, repair damage, switch the response off and recover while keeping reserve for the next challenge. Rather than replacing the hallmarks of aging, the framework treat… --- ## [Peptides / Bioregulators](https://www.rapamycin.news/t/peptides-bioregulators/11956)
**Author:** [@ksbradley](https://www.rapamycin.news/u/ksbradley)\ **Replies:** 1182\ **Last updated:** [November 2, 2026, 7:32pm UTC](https://www.rapamycin.news/t/peptides-bioregulators/11956 "2026-11-02T19:32:39Z")
Hey. I am an avid health enthusiast. Just starting Rapamycin as well as my lengthy supplement protocol. I don’t see a lot of people here mentioning Peptide therapy (BPC-157, Ipamorelin, CJC-1295 etc…) Who is taking them and results. I am a big fan of adding this into me regiment. Also my Peptide Bioregulators order just arrived and plan on starting them next. The research by Dr Khavinson is qu… --- ## [Cardiovascular Health 2026](https://www.rapamycin.news/t/cardiovascular-health-2026/23470)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 800\ **Last updated:** [November 2, 2026, 7:30pm UTC](https://www.rapamycin.news/t/cardiovascular-health-2026/23470 "2026-11-02T19:30:25Z")
Note: This thread is a continuation of the following threads: Cardiovascular Health 2024 Cardiovascular Health 2025 Normalizing blood sugar can halve heart attack risk New study shows: Prediabetes remission protects the heart and saves lives For the first time, an international analysis has shown that when people with prediabetes bring their blood glucose back into the normal range through lif… --- ## [Parkinson's disease](https://www.rapamycin.news/t/parkinsons-disease/6400)
**Author:** [@TomParkinson](https://www.rapamycin.news/u/TomParkinson)\ **Replies:** 1177\ **Last updated:** [November 2, 2026, 6:22pm UTC](https://www.rapamycin.news/t/parkinsons-disease/6400 "2026-11-02T18:22:56Z")
Has anyone had experience with taking rapamycin in relation to Parkinson’s? I was diagnosed with Parkinson’s in December 2020 & confirmed again by Datscan in January 2021. I do not take any medication but use alternative healing methods successfully. see www.parkinsonclub.de --- ## [Sleep Quality Beats Duration: Why Staying Asleep is the Hidden Key to Cognitive Longevity](https://www.rapamycin.news/t/sleep-quality-beats-duration-why-staying-asleep-is-the-hidden-key-to-cognitive-longevity/26939)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 4\ **Last updated:** [November 2, 2026, 6:21pm UTC](https://www.rapamycin.news/t/sleep-quality-beats-duration-why-staying-asleep-is-the-hidden-key-to-cognitive-longevity/26939 "2026-11-02T18:21:10Z")
A two-year longitudinal study tracking adults over age 55 reveals that simply spending more time in bed does not protect cognitive function. Researchers discovered that sleep efficiency, defined as the proportion of time in bed actually spent sleeping, is the only sleep metric significantly linked to preserved executive function. Total sleep duration, perceived sleep quality, and broad sleep he… --- ## [Pancreatic Beta Cells and TMAO & TMA](https://www.rapamycin.news/t/pancreatic-beta-cells-and-tmao-tma/27330)
**Author:** [@CronosTempi](https://www.rapamycin.news/u/CronosTempi)\ **Replies:** 1\ **Last updated:** [November 2, 2026, 5:43pm UTC](https://www.rapamycin.news/t/pancreatic-beta-cells-and-tmao-tma/27330 "2026-11-02T17:43:51Z")
A short 6 minute video. Stop Beta Cell Burnout: A Biological Secret to Protecting Your Pancreas from early retirement (via Better Body Chemistry TV) --- ## [Any news from Dr. Harold Katcher's E5 compound?](https://www.rapamycin.news/t/any-news-from-dr-harold-katchers-e5-compound/12790)
**Author:** [@Engadin](https://www.rapamycin.news/u/Engadin)\ **Replies:** 115\ **Last updated:** [November 2, 2026, 3:46pm UTC](https://www.rapamycin.news/t/any-news-from-dr-harold-katchers-e5-compound/12790 "2026-11-02T15:46:51Z")
Until last year I used to learn from Dr. Harold Katcher and Akshay Sanghavi lab research at Josh Mitteldorf’s Scienceblog. But now news from them in 2024 AFAIK. E5 has been so far a promising candidate as an antiaging compound but today noticing the late radio silence about it scares the devil out of me. Am I missing something I should know?. If any let it be good news please. Thanks. --- ## [Modern Healthspan Podcasts and Summaries](https://www.rapamycin.news/t/modern-healthspan-podcasts-and-summaries/26390)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 10\ **Last updated:** [November 2, 2026, 2:18pm UTC](https://www.rapamycin.news/t/modern-healthspan-podcasts-and-summaries/26390 "2026-11-02T14:18:59Z")
The Proven Daily Protocol to Protect Your Memory | Dr. David Perlmutter I. Executive Summary The presented discussion features neurologist David Perlmutter, MD, outlining a neuroimmunological and metabolic model of neurodegenerative disease pathogenesis. The central thesis asserts that Alzheimer’s disease (AD), Parkinson’s disease (PD), and related dementias are primarily driven by c… --- ## [Physionic Podcast Videos and Summaries / Transcripts](https://www.rapamycin.news/t/physionic-podcast-videos-and-summaries-transcripts/15904)
**Author:** [@DeStrider](https://www.rapamycin.news/u/DeStrider)\ **Replies:** 141\ **Last updated:** [November 2, 2026, 2:18pm UTC](https://www.rapamycin.news/t/physionic-podcast-videos-and-summaries-transcripts/15904 "2026-11-02T14:18:39Z")
I’m incredibly impressed with this guy and his aging research interpretation, that I think a topic of his own is warranted for quick reference. Here’s an example of his excellent work: --- ## [Rapamycin and Fibrosis Risk?](https://www.rapamycin.news/t/rapamycin-and-fibrosis-risk/12065)
**Author:** [@PLEIADES](https://www.rapamycin.news/u/PLEIADES)\ **Replies:** 32\ **Last updated:** [November 2, 2026, 10:16am UTC](https://www.rapamycin.news/t/rapamycin-and-fibrosis-risk/12065 "2026-11-02T10:16:10Z")
Hey everyone, I haven’t started taking rapamycin or one of the anlogs but I’m very interested in doing so. However, I recently came across a variety of journal articles which describe their experimental results and they demonstrate that rapamycin has pro-fibrotic properties. Some lab results in some labs show it causing fibrosis which is of course not what we want to see whereas others show the op… --- ## [18 Years of ITP Data: Excluding This Control Cohort Turns Intermittent Rapamycin From Lifespan Extension to a Trend Toward Reduction](https://www.rapamycin.news/t/18-years-of-itp-data-excluding-this-control-cohort-turns-intermittent-rapamycin-from-lifespan-extension-to-a-trend-toward-reduction/27328)
**Author:** [@Kawaii](https://www.rapamycin.news/u/Kawaii)\ **Replies:** 0\ **Last updated:** [November 2, 2026, 8:52am UTC](https://www.rapamycin.news/t/18-years-of-itp-data-excluding-this-control-cohort-turns-intermittent-rapamycin-from-lifespan-extension-to-a-trend-toward-reduction/27328 "2026-11-02T08:52:00Z")
Rapamycin’s status in the longevity field hardly needs elaborate setup. From the NIA Interventions Testing Program (ITP) first reporting mouse lifespan extension in 2006, to Harrison’s 2009 paper that electrified the field by showing benefit even when started at 20 months of age, to the 2025 PEARL trial’s signals of muscle and mood benefits in healthy older adults, this thread has stretched for ne… --- ## [Taurine Quiets the NLRP3 Inflammation Switch That Drives Aging](https://www.rapamycin.news/t/taurine-quiets-the-nlrp3-inflammation-switch-that-drives-aging/27226)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 7\ **Last updated:** [November 2, 2026, 5:15am UTC](https://www.rapamycin.news/t/taurine-quiets-the-nlrp3-inflammation-switch-that-drives-aging/27226 "2026-11-02T05:15:55Z")
This study overturns the premise of the 2023 taurine-deficiency hypothesis while partially rescuing its practical conclusion. Measuring taurine by mass spectrometry in two human cohorts and in mice, the Yale group found that circulating and tissue taurine rises with age rather than falling. They argue this rise is enantiostatic, meaning it is a compensatory response that opposes a destabilizing… --- ## [The Brain Got the DHA. Memory Didn’t Notice](https://www.rapamycin.news/t/the-brain-got-the-dha-memory-didn-t-notice/27286)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 5\ **Last updated:** [November 2, 2026, 4:40am UTC](https://www.rapamycin.news/t/the-brain-got-the-dha-memory-didn-t-notice/27286 "2026-11-02T04:40:22Z")
A two-year randomized trial at the University of Southern California tested whether a high daily dose of the omega-3 fat DHA could reach the brain and protect it in 365 older adults who ate little fish and had at least one dementia risk factor. Nearly half carried APOE4, the strongest common genetic risk factor for Alzheimer’s disease. Two grams of DHA per day raised DHA in the fluid surroundin… --- ## [Rapamycin and the Issue of Getting Through the Blood Brain Barrier](https://www.rapamycin.news/t/rapamycin-and-the-issue-of-getting-through-the-blood-brain-barrier/1336)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 99\ **Last updated:** [November 2, 2026, 3:14am UTC](https://www.rapamycin.news/t/rapamycin-and-the-issue-of-getting-through-the-blood-brain-barrier/1336 "2026-11-02T03:14:22Z")
Over the past year or so I’ve head many times that Blagosklonny takes a higher dose of rapamycin (20mg+) every two weeks because (he’s suggested) it helps increase the passage of the rapamycin through the blood brain barrier (and therefore increased mTOR inhibition in the brain), and I’ve asked him what research he based this on, but never got a response. Today I just found what may be the inf… --- ## [SGLT2 Drugs That Extend Mouse Lifespan Carry a Real Ketoacidosis Risk, Concentrated in Predictable Patients](https://www.rapamycin.news/t/sglt2-drugs-that-extend-mouse-lifespan-carry-a-real-ketoacidosis-risk-concentrated-in-predictable-patients/27306)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 15\ **Last updated:** [November 2, 2026, 1:19am UTC](https://www.rapamycin.news/t/sglt2-drugs-that-extend-mouse-lifespan-carry-a-real-ketoacidosis-risk-concentrated-in-predictable-patients/27306 "2026-11-02T01:19:17Z")
Researchers at Karolinska Institutet, Statens Serum Institut and Scandinavian partners used nationwide registers from Sweden, Denmark and Norway to study ketoacidosis in 282,282 adults with type 2 diabetes on SGLT2 inhibitors (mainly empagliflozin and dapagliflozin), covering 322,597 treatment episodes from 2013 to 2022. Over a median of 1.3 years, 1,452 ketoacidosis events occurred, 2.43 per 1… --- ## [Testosterone and Midlife Function: Physical and Cognitive Performance Evaluated](https://www.rapamycin.news/t/testosterone-and-midlife-function-physical-and-cognitive-performance-evaluated/27323)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 0\ **Last updated:** [November 1, 2026, 11:23pm UTC](https://www.rapamycin.news/t/testosterone-and-midlife-function-physical-and-cognitive-performance-evaluated/27323 "2026-11-01T23:23:15Z")
This systematic review from Ariel University and collaborating Israeli centers asked whether naturally occurring androgen levels track physical and cognitive performance in healthy middle-aged men. Following PRISMA guidelines with prospective PROSPERO registration, the authors searched three databases for observational studies published between 2010 and 2026, screened 485 records and included 1… --- ## [High Dose Riboflavin Nudges the Gut Toward Making More Butyrate](https://www.rapamycin.news/t/high-dose-riboflavin-nudges-the-gut-toward-making-more-butyrate/27325)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 1\ **Last updated:** [November 2, 2026, 12:06am UTC](https://www.rapamycin.news/t/high-dose-riboflavin-nudges-the-gut-toward-making-more-butyrate/27325 "2026-11-02T00:06:53Z")
The RIBOGUT trial randomized 105 healthy Dutch adults to placebo, 50 mg/day, or 100 mg/day of oral riboflavin for two weeks, testing whether high-dose vitamin B2 could expand populations of Faecalibacterium prausnitzii, a butyrate-producing gut anaerobe repeatedly linked to gut health. The primary endpoint failed outright. F. prausnitzii abundance did not change by either fluorescence microscop… --- ## [The 65-Year-Old Brain That Answered Faster: Reorganization, Not Decline, in Word Meaning](https://www.rapamycin.news/t/the-65-year-old-brain-that-answered-faster-reorganization-not-decline-in-word-meaning/27322)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 0\ **Last updated:** [November 1, 2026, 11:05pm UTC](https://www.rapamycin.news/t/the-65-year-old-brain-that-answered-faster-reorganization-not-decline-in-word-meaning/27322 "2026-11-01T23:05:31Z")
This study from Aalto University in Finland asked why behavioral studies find semantic skills stable with age while imaging studies report altered brain activity. Forty-six healthy native Finnish speakers, 25 aged 22 to 32 and 21 aged 62 to 69, judged whether word pairs were semantically related. Both groups exceeded 95% accuracy, and the older group responded faster. Brain responses differed s… --- ## [What a Lower Epigenetic Age Actually Tells You, and What It Does Not](https://www.rapamycin.news/t/what-a-lower-epigenetic-age-actually-tells-you-and-what-it-does-not/27321)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 0\ **Last updated:** [November 1, 2026, 10:44pm UTC](https://www.rapamycin.news/t/what-a-lower-epigenetic-age-actually-tells-you-and-what-it-does-not/27321 "2026-11-01T22:44:19Z")
This systematic review from Henan University of Chinese Medicine asked a question the field has mostly skipped: when an intervention lowers someone’s epigenetic age, do their clinical outcomes improve in parallel? The authors searched five databases through August 2026, screened 24,813 records, and included 26 human geroscience trials that measured both a DNA-methylation clock and a clinical ou… --- ## [The 45 to 55 Window: Why Midlife May Be the Best Time to Act on Vascular Aging](https://www.rapamycin.news/t/the-45-to-55-window-why-midlife-may-be-the-best-time-to-act-on-vascular-aging/27320)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 1\ **Last updated:** [November 1, 2026, 9:03pm UTC](https://www.rapamycin.news/t/the-45-to-55-window-why-midlife-may-be-the-best-time-to-act-on-vascular-aging/27320 "2026-11-01T21:03:05Z")
This narrative review from Tongji University in Shanghai argues that the vascular system, meaning arteries, veins and capillaries considered together, acts as a “pioneer organ” that ages early and spreads aging signals to the rest of the body. The authors draw mainly on a 2025 protein atlas of 13 human tissues, a multi-tissue study of aging monkeys, and mouse experiments showing that vesicles f… --- ## [Training Your VO2max, the Fitness Number That Best Predicts Lifespan](https://www.rapamycin.news/t/training-your-vo2max-the-fitness-number-that-best-predicts-lifespan/27231)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 21\ **Last updated:** [November 1, 2026, 6:44pm UTC](https://www.rapamycin.news/t/training-your-vo2max-the-fitness-number-that-best-predicts-lifespan/27231 "2026-11-01T18:44:27Z")
This systematic review and meta-analysis pooled 86 studies covering 239 high-intensity interval training (HIIT) protocols to find which workout designs keep people closest to their maximal oxygen uptake (VO2max) for longest, a measure called time at VO2max, or “red zone” time. Work intervals of 2 minutes or longer produced more red-zone time than shorter intervals in between-study comparisons, … --- ## [How to Stop or Reverse Skin Aging (2026)](https://www.rapamycin.news/t/how-to-stop-or-reverse-skin-aging-2026/23045)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 179\ **Last updated:** [November 1, 2026, 6:42pm UTC](https://www.rapamycin.news/t/how-to-stop-or-reverse-skin-aging-2026/23045 "2026-11-01T18:42:36Z")
mTOR inhibitor for Skin Health and Rejuvenation This is a continuation of this thread: How to Reverse Skin Aging (2025) It seems like the evidence for significant benefits of topical rapamycin (i.e. rapamycin skin cream) gets stronger and stronger every year. There are now two companies that are developing topical skin creams using mTOR inhibitors for skin aging: RapaLogix: A New Rapalog for… --- ## [Picking Up the Pace for 30 Minutes a Day Is Linked to Roughly a Third Lower Mortality Risk](https://www.rapamycin.news/t/picking-up-the-pace-for-30-minutes-a-day-is-linked-to-roughly-a-third-lower-mortality-risk/27318)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 1\ **Last updated:** [November 1, 2026, 6:02pm UTC](https://www.rapamycin.news/t/picking-up-the-pace-for-30-minutes-a-day-is-linked-to-roughly-a-third-lower-mortality-risk/27318 "2026-11-01T18:02:44Z")
Researchers analyzed wrist-accelerometer data from 64,743 UK Biobank participants, average age 61.5, followed a median of eight years with 1,697 deaths. They measured two things: total daily steps and peak 30-minute cadence, the average pace during a person’s fastest 30 minutes of the day, which need not be consecutive. Relative to the least active reference group, people taking fewer than 5,00… --- ## [SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice (BioRxiv)](https://www.rapamycin.news/t/sirt6-activator-fucoidan-extends-healthspan-and-lifespan-in-aged-wild-type-mice-biorxiv/19320)
**Author:** [@RapAdmin](https://www.rapamycin.news/u/RapAdmin)\ **Replies:** 19\ **Last updated:** [November 1, 2026, 5:52pm UTC](https://www.rapamycin.news/t/sirt6-activator-fucoidan-extends-healthspan-and-lifespan-in-aged-wild-type-mice-biorxiv/19320 "2026-11-01T17:52:51Z")
SIRT6 is a protein deacylase, deacetylase, and mono-ADP-ribosylase (mADPr) regulating biological pathways important for longevity including DNA repair and silencing of LINE1 retrotransposons. SIRT6 knockout mice die by 30 days of age, whereas SIRT6 overexpression increases lifespan in male mice. Finding safe pharmacological activators of SIRT6 would have clinical benefits. Fucoidan, a polysacchar… [Previous page](https://www.rapamycin.news/latest.md?page=1) [Next page](https://www.rapamycin.news/latest.md?page=3)