# Supplements **URL:** https://www.rapamycin.news/c/supplements/6.md?page=1 [Latest](https://www.rapamycin.news/latest.md) · [Categories](https://www.rapamycin.news/categories.md) · [Tags](https://www.rapamycin.news/tags.md) **Page:** 2 --- ## [I built a price-per-dose comparison tool for longevity supplements](https://www.rapamycin.news/t/i-built-a-price-per-dose-comparison-tool-for-longevity-supplements/24941)
**Author:** [@Isaac\_Vennik](https://www.rapamycin.news/u/Isaac_Vennik)\ **Replies:** 16\ **Last updated:** [June 12, 2026, 3:50am UTC](https://www.rapamycin.news/t/i-built-a-price-per-dose-comparison-tool-for-longevity-supplements/24941 "2026-06-12T03:50:06Z")
Hi all, I built a supplement price comparison tool that may be useful for people here who are comparing longevity stacks and trying to keep costs grounded. It’s called TrueServing: https://www.trueserving.app The basic idea is simple: instead of comparing bottle price or “price per serving” from the title, it reads Supplement Facts labels and normalizes products by cost per active dose. That ma… --- ## [YES! You can you reverse your T-Score... Normal... Osteopenia... Osteoporosi](https://www.rapamycin.news/t/yes-you-can-you-reverse-your-t-score-normal-osteopenia-osteoporosi/17811)
**Author:** [@Agetron](https://www.rapamycin.news/u/Agetron)\ **Replies:** 152\ **Last updated:** [May 27, 2026, 7:14am UTC](https://www.rapamycin.news/t/yes-you-can-you-reverse-your-t-score-normal-osteopenia-osteoporosi/17811 "2026-05-27T07:14:48Z")
As an early adopter of rapamycin… now over 4 years… I have been consistent with testing; otherwise, how does one know what is happening both good and bad. Going to share my first DEXA score and then my latest results the past week. DEXA score 2022, 2-years ago… osteopenia. Lumbar/spine T-Score -1.2 and Z - 0.5. Fracture risk increased. BUMMER! Okay… wasn’t great… but not the worst report ei… --- ## [Creatine Supplementation and its Potential Applications for Brain Health and Function](https://www.rapamycin.news/t/creatine-supplementation-and-its-potential-applications-for-brain-health-and-function/8165)
**Author:** [@Dexter\_Scott](https://www.rapamycin.news/u/Dexter_Scott)\ **Replies:** 6\ **Last updated:** [May 14, 2026, 8:30pm UTC](https://www.rapamycin.news/t/creatine-supplementation-and-its-potential-applications-for-brain-health-and-function/8165 "2026-05-14T20:30:23Z")
Useful article. Creatine supplementation has been shown to improve measures of cognition and memory (primarily in aging adults) and decreases symptoms of sleep deprivation in human and animal populations. Creatine supplementation also shows promise for alleviating some symptoms of TBI, including concussion, and characteristics of muscular dystrophy in humans. The efficacy of creatine for treatin… --- ## [Magnesium Recommendations](https://www.rapamycin.news/t/magnesium-recommendations/7057)
**Author:** [@StruggleBus](https://www.rapamycin.news/u/StruggleBus)\ **Replies:** 30\ **Last updated:** [May 13, 2026, 12:46pm UTC](https://www.rapamycin.news/t/magnesium-recommendations/7057 "2026-05-13T12:46:18Z")
Does anyone have a magnesium supplement they really like? I’m running out of mine and need to buy more. TIA --- ## [Anti-aging strategies and the ways to implement them](https://www.rapamycin.news/t/anti-aging-strategies-and-the-ways-to-implement-them/306)
**Author:** [@shc](https://www.rapamycin.news/u/shc)\ **Replies:** 25\ **Last updated:** [May 8, 2026, 2:55pm UTC](https://www.rapamycin.news/t/anti-aging-strategies-and-the-ways-to-implement-them/306 "2026-05-08T14:55:52Z")
I think such a list with resources would be nice to have, at least for optimizing our stacks and lifestyles to better serve our goals. Interventions for longevity: 1) Intermittent mTOR inhibition (for Increased Autophagy, reducing hyperfunction, reducing SASP) this would include fasting, IF, FMD, low protein diets, calorie restriction, metformin (via AMPK activation), berberine (via AMPK act… --- ## [Lithium Carbonate](https://www.rapamycin.news/t/lithium-carbonate/16385)
**Author:** [@judy\_bb](https://www.rapamycin.news/u/judy_bb)\ **Replies:** 3\ **Last updated:** [May 6, 2026, 5:45pm UTC](https://www.rapamycin.news/t/lithium-carbonate/16385 "2026-05-06T17:45:22Z")
The Dr who prescribes Rapamycin for me also prescribes Prednisone for Adrenal Insufficiency. I have developed Osteoporosis. I switched to Hydro-cortisone and now he is giving me Lithium to help my bones. He has me taking 150 mgs of Lithium Carbonate per day, which lists a lot of scary side effects. I have read on this site about people taking Lithium at much smaller doses, but it is Lithium Orota… --- ## [Resistant Starch / Green Banana Cuts Risk of Hereditary Cancer, Cardiometabolic Risk Factors](https://www.rapamycin.news/t/resistant-starch-green-banana-cuts-risk-of-hereditary-cancer-cardiometabolic-risk-factors/2393)
**Author:** [@Joseph](https://www.rapamycin.news/u/Joseph)\ **Replies:** 41\ **Last updated:** [May 1, 2026, 1:25am UTC](https://www.rapamycin.news/t/resistant-starch-green-banana-cuts-risk-of-hereditary-cancer-cardiometabolic-risk-factors/2393 "2026-05-01T01:25:19Z")
The Research Paper: https://aacrjournals.org/cancerpreventionresearch/article/doi/10.1158/1940-6207.CAPR-22-0044/707189/Cancer-Prevention-with-Resistant-Starch-in-Lynch?fbclid=IwAR0rc8\_VX6mIk3Yo86eThnLBRWHbnppqq7y2iLP5FiU5PX92QCaEYfRYyoA --- ## [Experiences with AMLA](https://www.rapamycin.news/t/experiences-with-amla/1815)
**Author:** [@Gary\_Patrick](https://www.rapamycin.news/u/Gary_Patrick)\ **Replies:** 17\ **Last updated:** [April 24, 2026, 4:14am UTC](https://www.rapamycin.news/t/experiences-with-amla/1815 "2026-04-24T04:14:30Z")
Just ordered some Amla and am curious about the experiences of other folks. How many grams do you take in a single serving? Do you take it daily? Once a day or more? Have you noticed any side effects, good or bad? If mixed in a smoothie, do you ever add additional ingredients? I am considering a smoothie with Amla and some collagen. --- ## [Any opinion on allulose?](https://www.rapamycin.news/t/any-opinion-on-allulose/22769)
**Author:** [@Rika\_Qu](https://www.rapamycin.news/u/Rika_Qu)\ **Replies:** 9\ **Last updated:** [April 21, 2026, 1:38am UTC](https://www.rapamycin.news/t/any-opinion-on-allulose/22769 "2026-04-21T01:38:31Z")
I reposted an article here about the allulose. Allulose seems to have similar benefits to Acarbose in terms of lowering postprandial glucose by inhibiting alpha-glucosidase. D-Allulose (or D-Psicose) is a naturally occurring rare sugar with some rather unique and tricky attributes. We can learn a lot from the comprehensive 2021 review: “Allulose in human diet: the knowns and the unknowns.” When … --- ## [GABA and improving sleep quality](https://www.rapamycin.news/t/gaba-and-improving-sleep-quality/20742)
**Author:** [@julianj1](https://www.rapamycin.news/u/julianj1)\ **Replies:** 24\ **Last updated:** [April 10, 2026, 7:25am UTC](https://www.rapamycin.news/t/gaba-and-improving-sleep-quality/20742 "2026-04-10T07:25:21Z")
I am very interested in sleep quality. At one time in my life I had sleep apnea. When I finally got a good night’s sleep with a CPAP machine I was totally amazed at the difference it made. That was a long time ago but the lesson was learnt and I very much try to have good sleep quality. However I am a bit of a worrier and that can keep me awake. I’ve experimented with a lot of different appro… --- ## [Study: Most NMN and Urolithin-A Supplements are Crap](https://www.rapamycin.news/t/study-most-nmn-and-urolithin-a-supplements-are-crap/14716)
**Author:** [@RapamycinCurious](https://www.rapamycin.news/u/RapamycinCurious)\ **Replies:** 49\ **Last updated:** [March 31, 2026, 2:18am UTC](https://www.rapamycin.news/t/study-most-nmn-and-urolithin-a-supplements-are-crap/14716 "2026-03-31T02:18:10Z")
From Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim. The white numbers are the code numbers for the (unidentified) NMN and UA products purchased online and from pharmacies. Half of the NMN You Buy Isn’t Really There: The Longevity Supplement Quality Scandal Scientists at the National University of Singapore bought 18 nicotinamide mononucleoti… --- ## [Niclosamide mTOR 1](https://www.rapamycin.news/t/niclosamide-mtor-1/1236)
**Author:** [@KFISH](https://www.rapamycin.news/u/KFISH)\ **Replies:** 7\ **Last updated:** [March 18, 2026, 9:39am UTC](https://www.rapamycin.news/t/niclosamide-mtor-1/1236 "2026-03-18T09:39:05Z")
Has anyone looked at #niclosamide? Interesting mTOR 1Inhibitor \[From RapAdmin: This video is from a guy who is promoting it as an mTOR1 inhibitor - seems like he’s just a guy who wants to make money off it. Lets not promote him, lets look at the data on niclosamide) --- ## [Glycine+NAC vs Rapamycin](https://www.rapamycin.news/t/glycine-nac-vs-rapamycin/1500)
**Author:** [@Goran](https://www.rapamycin.news/u/Goran)\ **Replies:** 377\ **Last updated:** [March 14, 2026, 12:56pm UTC](https://www.rapamycin.news/t/glycine-nac-vs-rapamycin/1500 "2026-03-14T12:56:47Z")
ITP study showed a 6% life extension in mice by Glycine, another study showed a 20% life extension in mice my Glycine + NAC (N-Acetyl Cysteine), That is close to Rapamycin territory. Rapamycin inhibits MTOR, and thats the theory on the reasons of longevity. Amino acids activate MTOR and Glycine and NAC are amino acids, so should in theory not be longevity candidates. I am using Glycine 8mg a… --- ## [Why You Aren’t Living to 500: A Brief History of Evolutionary "Hack Jobs"](https://www.rapamycin.news/t/why-you-aren-t-living-to-500-a-brief-history-of-evolutionary-hack-jobs/23897)
**Author:** [@Rika\_Qu](https://www.rapamycin.news/u/Rika_Qu)\ **Replies:** 5\ **Last updated:** [March 12, 2026, 9:29pm UTC](https://www.rapamycin.news/t/why-you-aren-t-living-to-500-a-brief-history-of-evolutionary-hack-jobs/23897 "2026-03-12T21:29:59Z")
Found an interesting article, repost it here. If humans were a species of bird or reptile, we would likely have surpassed a 200-year lifespan long ago, perhaps even pushing 500. The primary reason we don’t is that we inherited three massive piles of “biological legacy sh\*t” from our short-lived, R-strategy, burrowing-rodent ancestors. A few tens of millions of years simply wasn’t enough time for… --- ## [Betaine: A supplement that mimics exercise benefits](https://www.rapamycin.news/t/betaine-a-supplement-that-mimics-exercise-benefits/22077)
**Author:** [@jayeyen](https://www.rapamycin.news/u/jayeyen)\ **Replies:** 6\ **Last updated:** [March 12, 2026, 1:32pm UTC](https://www.rapamycin.news/t/betaine-a-supplement-that-mimics-exercise-benefits/22077 "2026-03-12T13:32:35Z")
Unlocking exercise’s anti-aging key: Betaine as first oral mimetic | EurekAlert! --- ## [NAD+: nicotinamide mononucleotide or nicotinamide riboside?](https://www.rapamycin.news/t/nad-nicotinamide-mononucleotide-or-nicotinamide-riboside/11590)
**Author:** [@Alex](https://www.rapamycin.news/u/Alex)\ **Replies:** 37\ **Last updated:** [March 9, 2026, 6:34am UTC](https://www.rapamycin.news/t/nad-nicotinamide-mononucleotide-or-nicotinamide-riboside/11590 "2026-03-09T06:34:23Z")
I am confused as to which is more effective. And further, it appears there is more than one form of nicotinamide riboside (NR) to consider (NR chloride and NR Hydrogen malate…I think?). In yor opinions, which is the most efficacious in raising NAD+? Or are there other alternatives as good or better? --- ## [Bryan Johnson's motives](https://www.rapamycin.news/t/bryan-johnsons-motives/18125)
**Author:** [@tdecicco7](https://www.rapamycin.news/u/tdecicco7)\ **Replies:** 74\ **Last updated:** [March 2, 2026, 8:33pm UTC](https://www.rapamycin.news/t/bryan-johnsons-motives/18125 "2026-03-02T20:33:38Z")
I see more and more ads from Bryan Johnson all over the net. I’ve reached the conclusion that he is just trying to make a couple of billion dollars in potentially lucrative nutritional supplements and related field. People have been making huge amounts of money and delivering very little in this field for decades now. You can see from this ad that he is expanding and has many products to sell you… --- ## [The "Death Warrant" for Intermittent Fasting?](https://www.rapamycin.news/t/the-death-warrant-for-intermittent-fasting/23780)
**Author:** [@Rika\_Qu](https://www.rapamycin.news/u/Rika_Qu)\ **Replies:** 7\ **Last updated:** [February 28, 2026, 1:15am UTC](https://www.rapamycin.news/t/the-death-warrant-for-intermittent-fasting/23780 "2026-02-28T01:15:44Z")
Sharing an interesting article on intermittent fasting https://www.zhihu.com/question/2005954269753390531/answer/2010395148404691510 I am writing this while in the middle of a fast, consuming nothing but sugar-free electrolytes. However, my heart is heavy. In the last few days, a top-tier study regarding intermittent fasting (IF) has been published, and it acts as a virtual “death warrant” for… --- ## [Are people using Peptides much? Do we know of reliable sources?](https://www.rapamycin.news/t/are-people-using-peptides-much-do-we-know-of-reliable-sources/23706)
**Author:** [@vic](https://www.rapamycin.news/u/vic)\ **Replies:** 2\ **Last updated:** [February 23, 2026, 3:30am UTC](https://www.rapamycin.news/t/are-people-using-peptides-much-do-we-know-of-reliable-sources/23706 "2026-02-23T03:30:11Z")
I was thinking of trying out SS-31 (Elamipretide) for mitochondria support and Semax for cognitive support. The two sources I was thinking of are https://buy.nobledragons.com/ and https://www.peptidesciences.com/. Has anyone used these? Would appreciate any insights into sourcing. thanks --- ## [PDE inhibitor, Ibudilast vs Tadalafil](https://www.rapamycin.news/t/pde-inhibitor-ibudilast-vs-tadalafil/23663)
**Author:** [@Rika\_Qu](https://www.rapamycin.news/u/Rika_Qu)\ **Replies:** 8\ **Last updated:** [February 20, 2026, 2:05pm UTC](https://www.rapamycin.news/t/pde-inhibitor-ibudilast-vs-tadalafil/23663 "2026-02-20T14:05:07Z")
Feature Ibudilast (AV-411 / KC-404) Tadalafil (Cialis) Primary Target PDE-4 (mainly), also PDE-10, 3, 11 PDE-5 (highly selective) Key Messenger Increases cAMP Increases cGMP Primary Effect Anti-inflammatory & Neuroprotective Vasodilation & Smooth Muscle Relaxation Main Use Cases Asthma, ALS, MS, Neuro-inflammation ED, BPH, Pulmonary Hypertension Half-Life ~19 hours (active meta… --- ## [BPC-157 + TB500 did nothing for me](https://www.rapamycin.news/t/bpc-157-tb500-did-nothing-for-me/23482)
**Author:** [@Prince](https://www.rapamycin.news/u/Prince)\ **Replies:** 20\ **Last updated:** [February 12, 2026, 11:08pm UTC](https://www.rapamycin.news/t/bpc-157-tb500-did-nothing-for-me/23482 "2026-02-12T23:08:53Z")
Got a BPC-157 5mg vial and a TB500 5mg vial Added 2ml of bacteriostatic water to BPC and 2ml of bacteriostatic water to TB Took about 10u of BPC and 70u of TB, along side GHK-Cu, 2 days per week, for about a total of 6 shots (2 tb500 vials) I have tendonites in both shoulder and I sprained my ankle Nov 1st. My decision to take the peptides was because i thought the ankle should be fine after 4 … --- ## [Safest online companies for purchasing GLP-1s](https://www.rapamycin.news/t/safest-online-companies-for-purchasing-glp-1s/18423)
**Author:** [@Melissa](https://www.rapamycin.news/u/Melissa)\ **Replies:** 51\ **Last updated:** [February 11, 2026, 7:57pm UTC](https://www.rapamycin.news/t/safest-online-companies-for-purchasing-glp-1s/18423 "2026-02-11T19:57:03Z")
Maybe previously discussed, but where is everyone buying their GLP-1s? Looking for safe online source. --- ## [Health Supplements for alleviating tinntinus](https://www.rapamycin.news/t/health-supplements-for-alleviating-tinntinus/6270)
**Author:** [@pollux](https://www.rapamycin.news/u/pollux)\ **Replies:** 16\ **Last updated:** [February 11, 2026, 3:23am UTC](https://www.rapamycin.news/t/health-supplements-for-alleviating-tinntinus/6270 "2026-02-11T03:23:07Z")
I ask ChatGPT the following question: what health supplements can alleviate the symptom of tinntinus? reply: Tinnitus is a condition characterized by ringing or buzzing in the ears that can be caused by various factors, including age-related hearing loss, ear injury, or exposure to loud noises. While there is no cure for tinnitus, some health supplements may help alleviate its symptoms. Here ar… --- ## [Review of Anti-Aging Drugs from Josh Mitteldorf](https://www.rapamycin.news/t/review-of-anti-aging-drugs-from-josh-mitteldorf/21077)
**Author:** [@Bruce4654](https://www.rapamycin.news/u/Bruce4654)\ **Replies:** 35\ **Last updated:** [February 5, 2026, 8:13pm UTC](https://www.rapamycin.news/t/review-of-anti-aging-drugs-from-josh-mitteldorf/21077 "2026-02-05T20:13:15Z")
Review of Anti-Aging Drugs - Josh Mitteldorf --- ## [Someone please help me! (Source Rapamycin)](https://www.rapamycin.news/t/someone-please-help-me-source-rapamycin/23491)
**Author:** [@ninagunn](https://www.rapamycin.news/u/ninagunn)\ **Replies:** 1\ **Last updated:** [February 5, 2026, 7:16am UTC](https://www.rapamycin.news/t/someone-please-help-me-source-rapamycin/23491 "2026-02-05T07:16:03Z")
IS ANYBODY COMING TO MEXICO SOON? Could someone be a darling and buy from that Lifespan plan some topical rampamycin as well as pills? I would pay for it. I just need to buy it and I ain’t got a visa. --- ## [Is it safe to take multiple 1mg rapamycin tablets in one go once a week as opposed to 1mg tablet every day?](https://www.rapamycin.news/t/is-it-safe-to-take-multiple-1mg-rapamycin-tablets-in-one-go-once-a-week-as-opposed-to-1mg-tablet-every-day/23473)
**Author:** [@dnomde\_setnad](https://www.rapamycin.news/u/dnomde_setnad)\ **Replies:** 3\ **Last updated:** [February 5, 2026, 4:51am UTC](https://www.rapamycin.news/t/is-it-safe-to-take-multiple-1mg-rapamycin-tablets-in-one-go-once-a-week-as-opposed-to-1mg-tablet-every-day/23473 "2026-02-05T04:51:29Z")
Sorry if this has been asked before and I’ve missed the thread. But if I have 1mg rapamycin tablets, would it be safe to take 4x1mg tablets once a week for example instead of 1mg every day? --- ## [Colchicine: Risky for Long-Term Brain Health?](https://www.rapamycin.news/t/colchicine-risky-for-long-term-brain-health/12818)
**Author:** [@darlie](https://www.rapamycin.news/u/darlie)\ **Replies:** 30\ **Last updated:** [February 3, 2026, 2:10am UTC](https://www.rapamycin.news/t/colchicine-risky-for-long-term-brain-health/12818 "2026-02-03T02:10:08Z")
I take colchicine .6-1.2mg/day for Behçet’s and know many of you do for cardiac protection as well. My concern is whether colchicine, a known neurotoxin, is actually a risky drug with respect to long-term effects on the brain. As I understand, colchicine is a neurotoxin which induces Alzheimer’s in rats when injected into the brain. This is uncontested and the subject of many papers. However, we… --- ## [Fisetin dosing 1,500mg for 2 days every 4-8 weeks - Is anyone considering this?](https://www.rapamycin.news/t/fisetin-dosing-1-500mg-for-2-days-every-4-8-weeks-is-anyone-considering-this/21785)
**Author:** [@Richard\_Alan](https://www.rapamycin.news/u/Richard_Alan)\ **Replies:** 4\ **Last updated:** [January 23, 2026, 4:04pm UTC](https://www.rapamycin.news/t/fisetin-dosing-1-500mg-for-2-days-every-4-8-weeks-is-anyone-considering-this/21785 "2026-01-23T16:04:49Z")
Wondering if anyone else has been testing out. I checked out usage with AI and it seemed positive, but pointed out there have been no long term trials: Emerging Clinical Evidence in Humans While robust human data are still limited, early clinical studies and pilot trials suggest that intermittent high-dose fisetin can indeed target senescent cells and lower inflammation in people. Fisetin is a… --- ## [The interaction between DORA and RAPA](https://www.rapamycin.news/t/the-interaction-between-dora-and-rapa/22619)
**Author:** [@Rika\_Qu](https://www.rapamycin.news/u/Rika_Qu)\ **Replies:** 3\ **Last updated:** [January 9, 2026, 6:29am UTC](https://www.rapamycin.news/t/the-interaction-between-dora-and-rapa/22619 "2026-01-09T06:29:16Z")
I tried lemborexant and find it amazing! In my N=1 experiement, micro-dosing 1mg lemborexant increased my deep sleep according to OURA ring. However I read both lemborexant and rapamycin are motabolized by CYP3A4 enzymes. I’m concerned about potential drug-drug interactions. Is it safe to take rapamycin in the morning and lemborexant at night? --- ## [Oral 17-alpha-Estradiol (17a-E2), 2026 update on dose, effects and sourcing + purity](https://www.rapamycin.news/t/oral-17-alpha-estradiol-17a-e2-2026-update-on-dose-effects-and-sourcing-purity/22961)
**Author:** [@Chris](https://www.rapamycin.news/u/Chris)\ **Replies:** 2\ **Last updated:** [January 6, 2026, 11:37am UTC](https://www.rapamycin.news/t/oral-17-alpha-estradiol-17a-e2-2026-update-on-dose-effects-and-sourcing-purity/22961 "2026-01-06T11:37:21Z")
Everybody with ORAL 17-Alpha-Estradiol experience, please share your updated information below on your daily dose, effects (feeling in nipples?) - and especially if you have test results from hormone levels before and after - and information on sourcing + purity for ORAL use. Please keep comments short, factual and scientific. To set the background information, below I have pasted in Gemini lat… [Previous page](https://www.rapamycin.news/c/supplements/6.md) [Next page](https://www.rapamycin.news/c/supplements/6.md?page=2)